Drug delivery compositions and methods

Abstract

A drug delivery composition is disclosed which includes a triple salt proxy functional group and at least one amino acid functional group. A method of forming the drug delivery composition includes reacting a triple salt with at least one amino acid in an aqueous environment. A biodegradable fabric is disclosed which includes a polymerized structure of a triple salt proxy functional group and at least one amino acid functional group.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of and claims the benefit of U.S. Non-patent application Ser. No. 14 / 675,836, filed Apr. 1, 2015, entitled “Drug Delivery Compositions and Methods,” which claims the benefit of U.S. Provisional Patent Application No. 61 / 973,903, filed Apr. 2, 2014, entitled “Drug Delivery Compositions and Methods,” the disclosures of both of which are incorporated by reference in their entirety and made part of the present U.S. utility patent application for all purposes.FIELD OF THE INVENTION[0002]This application is directed to drug delivery compositions and to methods for making and using the same, and more particularly to drug delivery compositions for wound treatment and to methods for making and using the same.BACKGROUND OF THE INVENTION[0003]The healing of a wound is a process that goes through a series of stages with varying cell types and chemical mediators in an appropriately moist environment. During this proc...

AI Technical Summary

Problems solved by technology

During this process, a wound site that is too moist or too dry may lead to inadequate cell proliferation.

Traditional bandages have been used in an effort to retain appropriate levels of moisture but are inadequate in many cases for a variety of reasons.

Additionally, bacteria are a significant concern during wound healing, as uncontrolled populations of bacteria, which naturally contaminate all wounds, may give rise to an infection with potentially catastrophic consequences.

This problem is complicated by the variety of bacteria which may be present, the increasing occurrence of drug-resistant bacteria, and patient drug allergies.

While bandages again have been used to keep additional contamination from reaching the wound, they are again largely ineffective in many cases and further have little or no impact on contamination existing prior to bandage application.

However, the amount of naturally occurring oxidative bursts is sometimes inadequate to quickly resolve contamination.

This leads to greater possibility of infection, particularly where environments having lesser or greater moisture undesirably result in slower healing.

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