Composition for hair loss prevention or hair growth stimulation comprising artemisia umbelliformis extract

a technology of artemisia umbelliformis and wormwood, which is applied in the field of compositions containing alpine wormwood (artemisia umbelliformis) extract, can solve the problems of severe hair loss, hair in the telogen phase is easily lost upon physical stimulation, and the mechanism of hair growth and hair loss has not been elucidated clearly. it promotes the proliferation of hair follicle cells or hair growth, and prevents hair loss or accelerates hair

Inactive Publication Date: 2017-08-03
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]In an aspect, because the composition containing an Alpine wormwood (Artemisia umbelliformis) extract as an active ingredient of the present disclosure promotes proliferation of hair follicle cells or growth of hair, it can provide an effect of preventing hair loss or accelerating hair growth.

Problems solved by technology

This lasts about 3 months and the hair in the telogen phase is easily lost upon physical stimulation.
Whereas hair loss is considered a normal physiological event for those with a lot of hair, those who suffer from severe hair loss can be badly affected in terms of mental well-being and quality of life due to depression, sense of shame, social isolation, etc.
Although promotion of hair growth and prevention of hair loss have been studied from ancient times, the mechanisms of hair growth and hair loss have not been elucidated clearly yet.

Method used

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  • Composition for hair loss prevention or hair growth stimulation comprising artemisia umbelliformis extract
  • Composition for hair loss prevention or hair growth stimulation comprising artemisia umbelliformis extract
  • Composition for hair loss prevention or hair growth stimulation comprising artemisia umbelliformis extract

Examples

Experimental program
Comparison scheme
Effect test

example 2

Measurement of Cell Proliferation (MTT Assay)

[0074]Each well of the 96-well plate was treated with an extract of Alpine wormwood (Artemisia umbelliformis) (0, 1, 2, 5, 10, 20 ppm) for 96 hours.

[0075]After adding 70 μg / mL of an MTT solution (Sigma, St Louis, Mo.) to each well, the cells were cultured for 3 hours in a CO2 incubator under a condition of 5% CO2 and 37° C. Then, after adding 100 μL of DMSO (Sigma, St Louis, Mo.) to each well, absorbance was measured at 570 nm. The result is shown in FIG. 1.

[0076]As can be seen from FIG. 1, the hair dermal papilla cells treated with the Alpine wormwood (Artemisia umbelliformis) extract of Example 1 showed increased cell viability. The increase was statistically significant. The statistical significance was tested by the paired Student's t-test. p<0.05 was considered statistically significant.

example 3

Observation of Growth of Hair Follicles

[0079]The 24-well plate was treated with an extract of Alpine wormwood (Artemisia umbelliformis) (0, 10, 50 ppm). A sample not treated with Alpine wormwood (Artemisia umbelliformis) was used as a control group. The medium was replaced every 2-3 days.

[0080]After treating with the Alpine wormwood (Artemisia umbelliformis) extract, the hair follicles were imaged using a stereoscopic microscope (Dongwon CNS, Korea) and hair growth length was measured using the ImageJ program. The result is shown in FIG. 2.

[0081]As can be seen from FIG. 2, the Alpine wormwood (Artemisia umbelliformis) extract promoted hair length growth in hair follicle, and the results are statistically significant.

[0082]Hereinafter, the formulation examples of the composition according to an aspect of the present disclosure are described. However, the following formulation examples are for illustrative purposes only and do not limit the scope of the present disclosure.

formulation example 1

Soft Capsule

[0083]8 mg of the Alpine wormwood (Artemisia umbelliformis) extract of Example 1, 9 mg of vitamin E, 9 mg of vitamin C, 2 mg of palm oil, 8 mg of hydrogenated vegetable oil, 4 mg of yellow beeswax and 9 mg of lecithin were mixed and prepared into a soft capsule-filling solution according to a commonly employed method. A soft capsule was prepared by filling 400 mg of the solution per capsule. Separately from this, a soft capsule sheet was prepared from 66 parts by weight of gelatin, 24 parts by weight of glycerin and 10 parts by weight of a sorbitol solution and filled with the filling solution to prepare a soft capsule containing 400 mg of the composition according to an aspect of the present disclosure.

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Abstract

Disclosed is a novel use of a composition comprising as an active ingredient an Artemisia umbelliformis extract. A composition according to the present description shows hair follicle cell proliferation or hair growth effect by means of comprising an Artemisia umbelliformis extract. Therefore, due to said effect, the Artemisia umbelliformis extract has hair loss prevention or hair growth stimulation effect.

Description

TECHNICAL FIELD[0001]The present disclosure relates to a composition containing an Alpine wormwood (Artemisia umbelliformis) extract.BACKGROUND ART[0002]Whereas most animals shed and regrow hair seasonally, humans shed about 100 strands of hair out of about 100,000 strands and about 100 strands regrow every day, thus always maintaining a similar number.[0003]The hair growth cycle consists of anagen, catagen and telogen phases. During the anagen phase, hair growth is promoted as cell division occurs actively in the hair dermal papilla, and hair grows only in this stage. Considering that the anagen is about 3-5 years for men and about 4-6 years for women, about 80-85% of hair is in the anagen phase. In the catagen phase, which lasts about 3-4 weeks, the cell division declines gradually. Lastly, in the telogen phase, the hair dermal papilla is withdrawn and the hair separated from the capillary vessel and simply stuck in the scalp. This lasts about 3 months and the hair in the telogen ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/539A61K9/00A61K47/10
CPCA61K36/539A61K9/0019A61K9/0014A61K47/10A61K8/97A61K36/282A61Q7/00A23V2002/00A23V2200/318A23V2250/21A61K9/08A61K9/1623A61K9/1652A61K9/2018A61K9/205A61K9/4858A61K9/4866A61K8/9789A61P17/12A61P17/14A61P43/00A23L33/105A23V2300/14A61K2236/33
Inventor PARK, PIL JOONSHIN, SEUNG HYUNLEE, HAE KWANGLEE, JON HWANLEE, TAE RYONGCHO, EUN GYUNG
Owner AMOREPACIFIC CORP
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