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Oral Care Composition

a technology of oral cavity and composition, applied in the field of oral care composition, can solve the problems of affecting the ability of chewing and swallowing, affecting the ability of people to chew and swallow, and soft tissue damage in the oral cavity is often very painful, and achieves the effect of accelerating the expression of hsp 27

Inactive Publication Date: 2017-12-28
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present patent demonstrates that the expression of a protein called HSP 27 is increased when soft tissue in the mouth is damaged. The inventors discovered that small amounts of a basic amino acid called arginine can quickly accelerate the expression of HSP 27. This suggests that using small amounts of arginine in oral care products could help to speed up healing and repair of damaged soft tissue in the mouth, as well as reduce inflammation and reduce reactive oxygen species. The oral care compositions described in this patent contain 0.001-0.08% arginine or a salt thereof, and are meant for use in preventing or repairing damage to soft tissue in the mouth, healing wounds, preventing inflammation, and reducing reactive oxygen species. The composition should be in contact with the mouth for at least 30 seconds, 1 minute, or more.

Problems solved by technology

Soft tissues of the oral cavity (for example, oral mucous membranes, gingival tissue and tongue) are susceptible to physical, physiochemical and biological injury.
Soft tissue damage in the oral cavity is often very painful and may even compromise a person's ability to chew and swallow.
There are a number of causes of soft tissue injury in the oral cavity, including poor-fitting braces and dentures, infection from microorganisms, physical trauma from biting or from sharp food, burns and allergies.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

on 1—Dentifrice

[0113]Table 1 illustrates an exemplary formulation according to the present invention.

TABLE 1IngredientsWeight (%)WaterQ.S.Precipitated calcium carbonate20-40Glycerin10-20Alkyl sulfate surfactant1-3Basic Amino Acid0.001-0.08 Tetrasodium pyrophosphate0.1-1  Sodium CMC1-3Sodium bicarbonate1-3Benzyl alcohol0.1-0.5Sodium saccharin0.1-0.5Flavor1-3Titanium Dioxide0.5-2  

example 2

Arginine on HSP 27 Production in Damaged Gingival Tissue

[0114]A scratching protocol was used to damage and stress human gingival tissue (MatTek Corporation). Arginine, at a dose of 50 ppm was applied to the culture medium containing the tissue. The treated tissue was incubated at 37° C. to promote tissue healing. Cell supernatant was collected at various time points and the level of HSP 27 was measured. The results are illustrated in Table 2.

TABLE 2Results of HSP 27 assay (gingival tissue)HSP27 concentration (ng / ml)IncubationScratchedArgininetime, hrUnscratcheduntreated50 ppm012.779.4822.7815.9087.88218.76415.16297.93359.72

[0115]As can be seen from Table 2, HSP27 was produced by the unscratched tissue at low levels which did not change significantly over time. There was an increased production of HSP 27 by the scratched tissue. Arginine, at the low dose of 50 ppm significantly accelerated, and in fact, enhanced, the production of HSP 27—there was a significantly increased amount of ...

example 3

of Human Keratinocytes in Response to Scratch Treatment

[0116]Human keratinocytes are cultured in DMEM medium supplemented with 10% FBS and 1% of antibiotic at 37° C. under a 5% CO2 atmosphere in petri dishes. Once the cells are 80-90% confluent, a scratch is made horizontally and a scratch is made vertically across the layer of cells. 1 ml of a test solution is added to the culture, and the cells are further incubated and monitored by photomicroscopy to evaluate the closure of the gap created by the scratches. The test solutions compared are 100 ppm Arginine in DMEM medium and untreated DMEM medium. The results are shown in Table 3 below, expressed as the average width of the gap as a percentage of the initial width of the gap (at 0 hours). It is found that under both conditions, the gap is fully closed at 144 hours, but that the gap proceeds to closure significantly faster in the presence of 100 ppm Arginine compared to the DMEM control.

TABLE 3Gap Closure After Scratch% Gap% GapClo...

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Abstract

Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

Description

BACKGROUND[0001]Soft tissues of the oral cavity (for example, oral mucous membranes, gingival tissue and tongue) are susceptible to physical, physiochemical and biological injury. Soft tissue damage in the oral cavity is often very painful and may even compromise a person's ability to chew and swallow. There are a number of causes of soft tissue injury in the oral cavity, including poor-fitting braces and dentures, infection from microorganisms, physical trauma from biting or from sharp food, burns and allergies.[0002]Various mediators and biological pathways are known to be involved in the maintenance of healthy tissue and in damage repair. Heat Shock Proteins (HSPs) in particular, are involved in multiple chaperoning and housekeeping functions, and aid in the folding or re-folding of denatured proteins that may arise from increased temperatures, tissue damage or stress. HSPs are found in most cells and tissues, and in extracellular and interstitial fluids such as blood and saliva....

Claims

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Application Information

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IPC IPC(8): A61Q11/00A61K8/21A61K8/24A61K8/44
CPCA61Q11/00A61K8/24A61K8/21A61K8/44A61K8/442A61K8/4946A61K31/198A61K31/4172A61P1/02
Inventor CHEN, DANDANTRIVEDI, HARSH MAHENDRAHILLIARD, PETER R.MASTERS, JAMES
Owner COLGATE PALMOLIVE CO
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