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Object-holding device

a technology of object holding and holding device, which is applied in the field of objects holding devices, can solve the problems of complex structure of the holding device including the vibration device, and the inability to release cell aggregates from the recess with a slight vibration

Inactive Publication Date: 2019-02-21
YAMAHA MOTOR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is a holding device that can keep an object on a plate in a scattered state. It has multiple holding parts that can hold the object.

Problems solved by technology

However, it is difficult to achieve such a desired holding state for cell aggregates.
However, the holding device including a vibration device has a complicated structure.
Further, when the holding portion has a shape of a recess and once the cell aggregates are caught in the recess, the cell aggregates cannot be released from the recess with a slight vibration.
As a result, the effect of dispersing the cell aggregates may fail to meet the expected level.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

first embodiment

[0065]Holding devices D according to several embodiments, including specific examples of the dispersing mechanism 3, are now exemplified. FIG. 11 is a block diagram schematically illustrating an object-holding device D1 according to a first embodiment. The holding device D1 generates a pressurization force in the closed region CA in the container 1 by using an air pressure, thereby generating the liquid flows LC in the through holes 22. The holding device D1 includes a dispersing mechanism 3A (pressure regulator), which is constructed of a pump 31 and a controller 32 therefor, in addition to the container 1 and the plate 2 described above. A camera 5 configured to take an image of the plate 2 is arranged below the container 1. The controller 32 controls not only the discharging operation of the dispenser tip 4 for a cell suspension, but also the imaging operation of the camera 5.

[0066]The container 1 is the same as the container 1 which has already been described with reference to F...

second embodiment

[0092]FIG. 15 is a block diagram schematically illustrating an object-holding device D2 according to a second embodiment. The holding device D2 applies a pressure to the liquid L by a diaphragm-type dispersing mechanism 3B, thereby generating the liquid flows LC in the through holes 22. The dispersing mechanism 3B includes a drive mechanism 33 including an actuator rod 331, and a controller 34 therefor. A part of the bottom wall 11 of the container 1 is formed of an elastically-deformable diaphragm 15 (bulging member). The actuator rod 331 is arranged in contact with the diaphragm 15. In the second embodiment, the working hole 141 is not used at the time of dispersion, and hence illustration of the working hole 141 is omitted in FIG. 15. The other configuration is the same as that of the first embodiment.

[0093]The drive mechanism 33 only needs to be capable of protruding and retracting the actuator rod 331, and for example, a hydraulic mechanism, a pneumatic mechanism, a solenoid ac...

third embodiment

[0098]FIG. 17 is a block diagram schematically illustrating an object-holding device D3 according to a third embodiment, and FIG. 18A is a top view of a container to be used in the holding device D3. The holding device D3 is a holding device according to a modified embodiment of the holding device D1 of the first embodiment. The holding device D3 has a structure capable of partially dispersing the cell aggregates C carried on the plate 2.

[0099]A container 1A of the holding device D3 includes partition walls 16 configured to partition the closed region CA in the container 1A into four segments. The partition walls 16 are two rectangular flat plates assembled orthogonal to each other, and therefore have a crossed shape in top view (FIG. 18A). The height of each partition wall 16 is equal to a distance between the bottom wall 11 of the container 1A and the plate 2. With such partition walls 16, the closed region CA is partitioned into a first segment RA, a second segment RB, a third se...

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Abstract

An object-holding device includes a container, a plate, and a dispersing mechanism. The container is configured to store a liquid, and includes an upper opening for charging an object into the stored liquid, and a bottom wall. The plate has an upper surface and a lower surface and is immersed into the liquid in a state in which the lower surface is spaced away from the bottom wall of the container, with this plate including: one or a plurality of holding portions arranged on the upper surface side and configured to carry the object; and a through hole passing through the holding portion from the upper surface to the lower surface. The dispersing mechanism is configured to form, in the through hole, a liquid flow which flows from the lower surface side toward the upper surface side to raise the object carried on the holding portion.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a Continuation of U.S. application Ser. No. 15 / 323,892 filed Jan. 4, 2017 and claims benefit of priority to International Patent Application No. PCT / JP2014 / 070632 filed Aug. 5, 2014, the entire content of which is incorporated herein by reference.TECHNICAL FIELD[0002]The present disclosure relates to a device configured to hold an object, such as a cell aggregate.BACKGROUND[0003]Devices configured to hold certain objects in a container that stores a liquid are required in some cases. For example, when the objects are cell aggregates, for the purpose of sorting, observation, cultivation, and the like of the cell aggregates, a plate including a large number of cell holding portions may be arranged in a cell culture liquid stored in the container, thereby holding the cell aggregates in the holding portions. Japanese Translation of PCT International Application publication No. 2009-504161 discloses a holding device configu...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12M1/32C12M1/00C12M1/34
CPCC12M23/34C12M41/40C12M29/14C12M23/12C12M47/04
Inventor ITO, SABURO
Owner YAMAHA MOTOR CO LTD