A multi-component injection

Pending Publication Date: 2019-09-05
TIANJIN CHASE SUN PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0096]The results indicate that 9 batches of multi-component injections in embodiments 3-5 can promote the apoptosis of Sepsis Treg and improve the secretion of cell factors of Treg and effector T cells, and are conducive to correcting the inhibitory state

Problems solved by technology

However, there are not enough specific medicines put int

Method used

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  • A multi-component injection
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Examples

Experimental program
Comparison scheme
Effect test

Example

Embodiment 1 Testing Method for Effective Ingredients in Injection

[0103]Method 1: Chromatographic Separation Conditions for Analyzing Ingredients of Safflower Carthamus and Red Paeony Root

[0104]Chromatographic column: Waters HSS T3 UPLC C18 Chromatographic column (100 mm×2.1 mm; 1.8 μM, Waters, USA);

[0105]Column temperature: 45° C.;

[0106]Mobile phase: A: H2O (containing 25 mM HCOOH, B: MeOH (containing 25 mM HCOOH);

[0107]Gradient elute is shown in Table 6; flow velocity: 0.35 mL / min; injection volume: 5 μL; analysis time: 13 min.

TABLE 6Liquid-phase gradient elute conditions of ingredients of safflowercarthamus and Red Paeony RootTime (min)Solvent ASolvent B0.098%2%8.030%70%11.02%98%13.098%2%

[0108]Method 2: Chromatographic Separation Conditions for Analyzing Ingredients of Radix Salviae Miltiorrhizae

[0109]Chromatographic column: Waters HSS T3 UPLC C18 Chromatographic column (100 mm×2.1 mm; 1.8 μM, Waters, USA);

[0110]Column temperature: 45° C.;

[0111]Mobile phase: A: H2O (containing 25...

Example

Embodiment 2 Preparation of Multi-Component Injection

[0117]providing 100 g of Red Paeony Root decoction pieces; heating and boiling the Red Paeony Root decoction pieces with process water of 10 times the weight of the Red Paeony Root decoction pieces to obtain a first decoction after 2 hours slight boiling; filtering the first decoction to obtain filtrate I and a first dreg; boiling the first dreg with process water of 8 times the weight of the first dreg to obtain a second decoction after 1 hour slight boiling; filtering the second decoction to obtain filtrate II and a second dreg; mixing filtrate I and filtrate II to obtain a mixture; concentrating the mixture to obtain a first concentrate of 100 ml; adding a proper amount of gelatin solution to the first concentrate under stirring to obtain a gelatin-containing first concentrate; adding 95% ethanol to the gelatin-containing first concentrate to obtain an ethanol-containing first concentrate having an ethanol volume content of 70%...

Example

Embodiment 3 Preparation Process of Multi-Component Injection

[0120]providing 100 g of safflower carthamus decoction pieces; leaching the safflower carthamus decoction pieces with 30% ethanol of 8 times the weight of the safflower carthamus decoction pieces for 8 hours to obtain a leach liquor; filtering the leach liquor to obtain a liquid medicine of 4-6 times the weight of the safflower carthamus decoction pieces; adding 95% ethanol to the liquid medicine to obtain an ethanol-containing liquid medicine having an ethanol volume content of 70%; storing the ethanol-containing liquid medicine under cooling condition for 48 hours to obtain a cool ethanol-containing liquid medicine; filtering the cool ethanol-containing liquid medicine to obtain a first filtrate; concentrating the first filtrate under reduced pressure to obtain a concentrate of 100 ml; adding 95% ethanol to the concentrate to obtain an ethanol-containing concentrate having an ethanol volume content of 80%; storing the et...

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Abstract

The invention relates to the technical field of medicines, and particularly relates to a multi-component injection and preparation processes and applications thereof. In the present invention, the effective ingredients of safflower carthamus. Red Paeony Root, Ligusticum wallichii, radix salviae miltiorrhizae and Angelica sinensis are analyzed and a multi-component injection is prepared via the modern pharmaceutical preparation technology. The study proves that the multi-component injection of the invention has therapeutic effects on Sepsis.

Description

I. TECHNICAL FIELD[0001]The present invention relates to the technical field of medical technology, and particularly relates to a multi-component injection and preparation processes and applications thereof.II. BACKGROUND OF THE INVENTION[0002]Sepsis is a fatal organ dysfunction caused by the reaction disorder of the infected hosts, with a hospital mortality of more than 10%, which has posed a huge threat to human health, becoming a focus to which the medical field pays close attention [see JAMA. 2016 Feb. 23; 315(8):801-10]. Under the big data retrospective analysis in combination with the microarray technology and analysis of leukocyte gene expression, people gradually realize that Sepsis is not only a process of systemic inflammatory reaction or immune disorder, but also a complex chronic critical disease combining sustained inflammation, immunosuppression and catabolism. [See J Trauma Acute Care Surg. 2012 June; 72(6): 1491-501, BMJ. 2016 May 23; 353: i1585 and Medicine (Baltimo...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/7048A61K31/192A61K31/235A61K31/353A61K36/65A61K31/513A61K31/52A61K31/198A61K31/7064A61K31/7076A61K31/194A61K36/28A61K31/708A61K31/343A61K36/236A61K36/232A61K36/537A61P31/04
CPCA61K9/0019A61K2236/53A61K31/192A61K31/235A61K31/353A61K36/65A61K31/513A61K31/52A61K31/198A61K31/7064A61K31/7076A61K31/194A61K36/28A61K31/708A61K31/343A61K36/236A61K36/232A61K36/537A61P31/04A61K2236/39A61K2236/333A61K2236/331A61K2236/37A61K31/7048A61K47/26A61K9/08A61K2300/00A61K36/286
Inventor YAO, XIAOQINGSUN, CHANGHAIDONG, KAILI, CHUANZHANG, GUIPINGDONG, TIANHAOCAO, JINGWANG, QIYUNLI, XIANJUNGAO, JUNMINSUN, MINGZHEN
Owner TIANJIN CHASE SUN PHARM CO LTD
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