2 results about "Androgen receptor activity" patented technology

The present application relates to a kind of compound with anti-androgen receptor activity and its use, the present application provides the compound shown in formula I, its racemate, stereoisomer, tautomer, solvate, polymorph or their pharmaceutically acceptable salt.The compound has good prostate tumor cell proliferation inhibitory activity and anti-AR activity.The compound has good in vivo metabolic properties, AUC and C max Both are higher, and the drug has good property, can be used for preventing and / or treating male hormone related disorder disease.The compound of the present application also has good hair production promoting effect, can effectively increase the number of hair follicle and the length of hair growth.

This invention belongs to the field of biomedical materials technology, specifically relating to an ionic liquid for improving androgenetic alopecia and its applications. The ionic liquid is prepared according to the following steps: L-L-carnitine and succinic acid are reacted under inert conditions to obtain an L-L-carnitine-succinic acid ionic liquid with an ion-hydrogen bond network structure; vanillin is added to the L-L-carnitine-succinic acid ionic liquid, and the mixture is heated and stirred to obtain the ionic liquid. This ionic liquid can function in the microenvironment of dermal papilla cells, improving the hair follicle microenvironment and enhancing the activity of dermal papilla cells, which play a key role in androgenetic alopecia. Furthermore, this drug-loaded ionic liquid can effectively inhibit androgen receptor activity, preventing the binding of androgens and androgen receptors from causing problems such as hair follicle miniaturization and hair loss. Simultaneously, it also has the effect of improving androgenetic alopecia and promoting hair growth.