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7 results about "Galectin-3" patented technology

Q: How to Galectin-3?

Galactoside inhibitor of galectins,Anti-galectin 3 antibodies and their use in epilepsy and related diseases,Trim proteins and galectins cooperate and codirect autophagy and are useful in the treatment of autophagy related diseases,Anti-galectin 3 antibodies and their use in epilepsy and related diseases,Anti-galectin 3 antibodies and their use in epilepsy and related diseases

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Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified. Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides.

Galactoside inhibitor of galectins

ActiveUS12441754B2Sugar derivativesRespiratory disorderAutoimmune conditionAutoimmune disease

The present invention relates to a D-galactopyranose compound of formula (1)whereinthe pyranose ring is α-D-galactopyranose, and these compounds are high affinity galectin-1 and / or galectin 3 inhibitors for use in treatment of inflammation; fibrosis; scarring; keloid formation; aberrant scar formation; surgical adhesions; septic shock; cancer; metastasising cancers; autoimmune diseases, metabolic disorders; heart disease; heart failure; pathological angiogenesis; eye diseases; atherosclerosis; metabolic diseases; diabetes type I; diabetes type II; insulin resistance; Diastolic heart failure; asthma; liver disorders.

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Owner:GALECTO BIOTECH

Anti-galectin 3 antibodies and their use in epilepsy and related diseases

PendingCA3316258A1Antiendomysial antibodiesAgglutinin

Provided herein are antibodies that target Galectin-3. Such antibodies are used in methods of treating epilepsy and related neurological disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD).

Owner:SUNMED THERAPEUTIC LTD

Trim proteins and galectins cooperate and codirect autophagy and are useful in the treatment of autophagy related diseases

ActiveUS12285470B2Antibacterial agentsPeptide/protein ingredientsMycobacterium InfectionsLysosome

Tie present invention relates to compositions and methods of influencing autophagy by modulating TRIM (tripartite motif containing) proteins, especially TRIM 8, TRIM: 10, TRIM 16, TRIM 19 and / or TRIM 51 (preferably TRIM 16} and galectins, especially galectins 3 m order to influence autophagy and treat a number of disease states and / or conditions which are mediated and / or influenced by autophagy, including inflammatory disease states and / or conditions, including a microbial infection such as a Mycobacterium infection, among numerous others, an inflammatory disorder, a lysosomal, storage disorder, an immune disorder, a neurodegenerative disorder and a cancer.