The invention discloses double-network hydrogel based on host-guest interaction and amino-
imide reaction and a preparation method and application thereof, and relates to the field of intelligent hydrogel materials, the preparation method comprises the following steps: S1,
grafting a beta-
cyclodextrin amino derivative to polysuccinimide to obtain a polysuccinimide derivative with a host unit for later use; s2,
amantadine is grafted to polysuccinimide, and a polysuccinimide derivative with a guest unit is obtained; and S3, mixing the polysuccinimide derivative with the host unit, the polysuccinimide derivative with the guest unit and an amino donor compound with deionized water, adjusting the pH value of the mixed
system to be greater than 7, and reacting to obtain the dual-network hydrogel. The hydrogel is endowed with intelligence through the participation of the subject-object interaction of
cyclodextrin and
adamantane, the
mechanical property of the hydrogel is guaranteed through the clamping of the
covalent bond interaction, and the problem that the
mechanical property and the intelligence of a conventional hydrogel material are not considered at the same time is solved.