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Composite amino acid and vitamine capsule preparation and its preparing method

A technology of compound amino acids and vitamins, which is applied in capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. Beautiful, improve the dissolution of VE, shorten the production cycle effect

Active Publication Date: 2008-07-16
NANJING SANHOME PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary excipients that regulate disintegration and drug release cannot solve the dissolution problem of products
Moreover, various components of common preparations interact with each other, resulting in poor stability
Although CN1424027A can solve the problem of poor stability, the production cost is too high, and it is not suitable for large-scale production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The prescription consists of:

[0060] 1. Amino acid granules:

[0061] (a) Isoleucine 150g / 10,000 capsules

[0062] (b) Leucine 170g / 10,000 capsules

[0063] (c) Lysine hydrochloride 187.5g / 10,000 capsules

[0064] (d) Phenylalanine 100g / 10,000 capsules

[0065] (e)Methionine 150g / 10,000 capsules

[0066] (f) Threonine 100g / 10,000 capsules

[0067] (g) Tryptophan 50g / 10,000 capsules

[0068] (h) Valine 150g / 10,000 capsules

[0069] (i) Arginine hydrochloride 180g / 10,000 capsules

[0070] (j)PVP 152g / 10,000 capsules

[0071] (k)Red Opadry 433g / 10,000 capsules

[0072] (1) Brown Opadry 433g / 10,000 capsules

[0073] 2. Vitamin granules:

[0074] (m) Vitamin B 1 Nitrate 50g / 10,000 capsules

[0075] (n) vitamin B 2 20g / 10,000 tablets

[0076] (o) vitamin B 6 75g / 10,000 tablets

[0077] (p)Vitamin E acetate 25g / 10,000 capsules

[0078] (q) Niacinamide 150g / 10,000 capsules

[0079] (r) Lactose 140g / 10,000 capsules

[0080] (s) Starch 240g...

Embodiment 2

[0096] The compound amino acid and vitamin capsule prepared by the method of the present invention is compared with the dissolution rate of the compound amino acid capsule (trade name: He'an) of commercially available Shenzhen Wanhe Pharmaceutical Co., Ltd. The compound amino acid and vitamin capsule and He'an (batch number: 040202) prepared according to Example 1 were tested according to the dissolution test method described in the Pharmacopoeia, and the results are shown in Table 1.

[0097] Table 1. Dissolution Comparison

[0098] sample

Embodiment 3

[0100] Investigation on the stability of the compound amino acid and vitamin capsule prepared by the method of the present invention. The compound amino acid and vitamin capsule prepared by Example 1 was placed at room temperature for 12 months, and its stability was investigated by the method for measuring dissolution in the Pharmacopoeia. The results are shown in Table 2.

[0101] Table 2. Stability investigation of compound amino acid and vitamin capsules

[0102] Inspection time

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PUM

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Abstract

The composite amino acid and vitamin capsule preparation includes coated amino acid granules and coated vitamin granules in the weight ratio of 1 to 0.68. The coated amino acid granules include isoleucine, leucine, lysine hydrochloride, phenylalanine, methionine, threonine, tryptophan, valine and arginine hydrochloride; and the coated vitamin granules include vitamin B1 nitrate, vitamin B2, vitamin B6, vitamin E acetate, and nicotinamide. The present invention also provides the preparation process of the composite amino acid and vitamin capsule preparation.

Description

technical field [0001] The invention relates to a compound amino acid and vitamin capsule preparation and a preparation method thereof. Background technique [0002] Amino acids and vitamins are the basic substances necessary for the human body to maintain normal life activities and health. Amino acids are derived from protein, decomposed into amino acids in the body, absorbed by the small intestine, stored in the cells and plasma of bones, muscles and organs through the liver, and used in protein synthesis and metabolism. Amino acids are essential components for protein synthesis of muscles, skin, organs, enzymes, and immune antibodies in the body. Leucine, isoleucine, and valine can strengthen liver function, lysine and threonine can quickly convert energy in the body, methionine can detoxify and protect liver function, tryptophan can sleep, and arginine can promote sleep. In protein synthesis, phenylalanine is a precursor of tyrosine. Most vitamins cannot be synthesize...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/525A61K31/51A61K31/455A61K31/4415A61K31/405A61K31/355A61K31/198A61K9/48A61P3/02
Inventor 张仓滕再进
Owner NANJING SANHOME PHARMACEUTICAL CO LTD
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