Application of magnolia vine fruit in preparation of anti-tumor medicine or multi-medicine tolerant reversal agent

An anti-tumor drug, multi-drug resistance technology, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of no anti-tumor reports, hindering clinical applications, and no anti-tumor multi-drug resistance.

Inactive Publication Date: 2009-05-27
高陈勇
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its calcium antagonistic activity on blood vessels and myocardium has nothing to do with its MDR reversal effect, but is related to the side effects of the cardiovascular system, and its side effects seriously hinder clinical application
[0006] Schisandra chinensis, the dry mature fruit of Magnoliaceae Schisandra chinensis (Turcz.) Baill. or Magnoliaceae Schisandra sphenanthera Rehd.et Wils. Schisandra sphenanthera Rehd.et Wils. It has the functions of astringent, nourishing qi, promoting body fluid, nourishing the kidney and calming the heart. It is a nourishing and strengthening drug commonly used in traditional Chinese medicine. It has various pharmacological effects, but there are no clear reports of anti-tumor effects, especially no reports of anti-tumor multi-drug resistance.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of magnolia vine fruit in preparation of anti-tumor medicine or multi-medicine tolerant reversal agent
  • Application of magnolia vine fruit in preparation of anti-tumor medicine or multi-medicine tolerant reversal agent
  • Application of magnolia vine fruit in preparation of anti-tumor medicine or multi-medicine tolerant reversal agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Extraction of Schisandra chinensis

[0033] Reflow method:

[0034](a) take 15000g of Schisandra chinensis as raw material;

[0035] (b) pulverizing the fruit of Schisandra chinensis into coarse powder, and soaking it in 4 times the amount of 90% ethanol for 12 hours. The required concentration of ethanol here can be 50% to 100%, usually 70% to 90% ethanol is selected as the extractant, and the soaking time can be 6 to 24 hours.

[0036] (c) the Schisandra chinensis ethanol soaking solution in step (b) was extracted at reflux temperature for 3 hours, filtered, and the filtrate was collected;

[0037] (d) adding 3 times the amount of 90% ethanol to the filter residue in step (c), extracting at reflux temperature for 2 hours, filtering and collecting the filtrate;

[0038] (e) adding 3 times the amount of 90% ethanol to the filter residue in step (d), extracting at reflux temperature for 2 hours, filtering and collecting the filtrate;

[0039] (f) merge the...

Embodiment 2

[0041] Example 2: Extraction of Schisandra chinensis

[0042] Percolation method: Take 5000g of Schisandra chinensis powder and permeate it with 6 times the amount of 95% ethanol, and the percolation speed is 15ml / min. The ethanol leachate is recovered, and the ethanol is recovered under reduced pressure until there is no ethanol smell, and concentrated to obtain an extract with a specific gravity of 1.15 g / ml, which is for subsequent use. The above ethanol can also be replaced by various alcohols such as methanol and propanol; other organic solvents such as ethyl acetate and ether solvents can also be replaced.

Embodiment 3

[0043] Example 3: Extraction of Schisandra chinensis

[0044] Supercritical extraction: pulverize 1000g of Schisandra chinensis sample into coarse powder (pass through a 40-mesh sieve), put 1L of supercritical CO 2 In the extraction kettle, adjust the pressure: 25MPa, the temperature: 45°C, the flow rate: 30kg / h, and the extraction time: 2h. The brown extract was collected.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides the use of schisandra fruit in preparing medicament for treating tumors, wherein the schisandra is a plant of Schisandra chinesis(Turcz.)Baill. belonging to Magnoliales, it can effectively inverse the multi-drug tolerance of the tumors. The extracts of schisandra fruit can be acted on P-glucoprotein, MRP1 and MXR.

Description

(1) Technical field [0001] The invention relates to the clear application of Chinese herbal medicine Schisandra chinensis in the preparation of medicines for treating tumors, especially the application of Schisandra chinensis in the preparation of anti-tumor cell multidrug resistance reversing agent medicines. (2) Background technology [0002] Tumor is one of the main causes of human death, and tumor chemotherapy is one of the main methods to treat tumors. However, tumor chemotherapy fails because tumor cells acquire drug resistance. [0003] There are many reasons for the multidrug resistance of tumor cells, the most important of which is that tumor cells express ATP binding cassette (ABC) transporters. P-glycoprotein (P-gp), multidrug resistant associated protein 1 (MRP1) and breast cancer resistance protein BCRP (also known as MXR or ABCG2), It is currently recognized as several major proteins that lead to tumor multidrug resistance. These proteins are all transmembra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/79A61P35/00A61K131/00
Inventor 胡汛
Owner 高陈勇
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap