New use and preparation of smoke tree extract for Chinese medicine

A technology of extract and water extract, which is applied in the field of new uses and preparations of Chinese medicine Cotinus cotinus extract, can solve the problems that Cotinus cotinus has no anticoagulant, antithrombotic, blood pressure lowering effects and therapeutic drugs, etc., and achieve extraction and preparation The method is simple and easy to implement, and the effect of a wide range of drug sources

Inactive Publication Date: 2009-08-05
崔恩贤 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no record of Cotinus cotinus in terms of anticoagulant, antithrombotic, hypotensive effects and therapeutic drugs.

Method used

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  • New use and preparation of smoke tree extract for Chinese medicine
  • New use and preparation of smoke tree extract for Chinese medicine
  • New use and preparation of smoke tree extract for Chinese medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) The preparation method of the water extract of Sumac water extract: take 100g of the Chinese herbal medicine Sumac medicinal pieces, add 800ml of water and boil it for 2-3 times, filter and concentrate to 100ml, then add 100ml of ethanol with a concentration of 95%, let it stand overnight, and pour out the supernatant. Filter, remove the kneading quality, and recover the ethanol to prepare 1g / 1ml aqueous solution, keep it away from light, airtight, and low temperature for later use, and then dilute to the required concentration before use.

[0019] (2) The anticoagulant and antithrombotic effects of the traditional Chinese medicine Huang Zhi

[0020] 1. Experimental method

[0021] Ice water-adrenaline type rat thrombosis model modeling: Take 60 SD rats, male and female, weighing 180-220g, and randomly divided into 6 groups according to body weight, each group of 10: ① Normal group (1ml / 100g Body weight, intragastric distilled water); ②Model group (1ml / 100g body weight,...

Embodiment 2

[0038](1) The preparation method of Corydalis injection: take a proper amount of decoction pieces of Corydalis coggygria, dry, pulverize, weigh 100g into a beaker, soak in 800ml distilled water for half an hour, extract by heating, filter and concentrate to obtain 100ml water concentrate. Add an appropriate amount of 95% ethanol to the concentrated solution to make the alcohol content reach 85%, stand overnight, filter, adjust the pH to 8.0 with 40% NaOH, stand overnight, and filter to obtain the filtrate. Then filter with paper pulp to obtain a reddish-brown clear filtrate. The ethanol is recovered by steam distillation (and a thermometer is installed to show whether the ethanol is fully recovered). After the concentrated solution is obtained, adjust the pH to 7 and put it into a clean ground reagent bottle and circulate. After 45 minutes of steam sterilization, put it in the refrigerator for later use, and then dilute to the required concentration before use.

[0039] (2) Experi...

Embodiment 3

[0049] Example 3: A pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof.

[0050] Through the in vitro experiments and pharmacodynamic experiments of Example 1 and Example 2, it is proved that the extract of Scutellaria scoparia has obvious anticoagulant, antithrombotic and blood pressure lowering effects, and provides a new method for the treatment of cardiovascular and cerebrovascular diseases. The choice of medication has the advantages of significant curative effect, low price, safe and convenient use.

[0051] Preparation method: Take 100g of Chinese cocklebur medicinal pieces, add 800ml of water and boil it for 2-3 times, filter and concentrate to 100ml, then add 100ml of ethanol with a concentration of 95%, let stand overnight, pour out the supernatant, filter, and remove the rubbing quality. After the ethanol is recovered, the aqueous solution is prepared, and the cocklebur aqueous solution is concentrated to...

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PUM

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Abstract

The invention relates to a new application and preparation of a Chinese medicine cotinus cotinus extract, in particular to the application of the cotinus cotinus extract in the preparation of anticoagulant medicine, the application in the preparation of antithrombotic medicine, and the application in the preparation of blood pressure lowering medicine. It can be made into pharmaceutical preparations such as capsules, granules, tablets, powders, and oral liquids. It provides a new drug option for treating cardiovascular and cerebrovascular diseases, and has the advantages of remarkable curative effect, low price, safe and convenient use, and the like.

Description

Technical field [0001] The invention relates to a new use and preparation of a Chinese medicine Cotinus coggygria extract. Background technique [0002] Cotinus coggygra Scop. (Cotinus coggygra Scop.) belongs to the genus Cotinus coggygria, a deciduous shrub or small tree, with a height of up to 8m. The color of the leaves turns red after frost in autumn. It is commonly known as Xiangshan Hongye. Although the plant has not been entered into the Chinese Pharmacopoeia as a medicinal material, many pharmacodynamic tests in recent years have shown that it has antibacterial effects, significant anti-hepatitis activities and obvious anti-fatigue effects. But so far, there is no record of the anticoagulant, antithrombotic, blood pressure lowering effects and therapeutic drugs of S. chinensis. Summary of the invention [0003] Effects of the present inventors on the whole blood clotting time after administration of the water extract of the rhizome of Scutellaria chinensis rhizome to ani...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/22A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P7/02A61P9/12A61K125/00A61K135/00
Inventor 崔恩贤龙丽辉
Owner 崔恩贤
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