HCV composite multi-epitope transgene plant oral vaccine

Abstract

The invention is a hepatitis C virus (HCV) compound multi-epitope transgene edible plant vaccine. The HCV vaccine is obtained by expressing the HCV compound multi-epitope antigen gene in a plant expression host system, and the plant expression host is edible. The invention provides an efficient and cheap HCV vaccine which can provide cross-protection against different types and different HCV isolates.

Description

1. Technical field [0001] The invention belongs to the field of molecular biology and relates to an edible transgenic vaccine prepared by using plants, in particular to a transgenic edible vaccine for preventing human hepatitis C virus infection; the amino acid sequence of the recombinant protein; encoding the recombinant protein The nucleotide sequence of the vaccine (hereinafter sometimes referred to as "gene"); the expression vector containing the nucleotide sequence; the host cell containing the expression vector. 2. Background technology [0002] Hepatitis C is an infectious disease that seriously affects human health. It can easily transform into liver cirrhosis and hepatocellular carcinoma. At present, there is no ideal prevention and treatment method. It is one of the important sources of disease that endangers human health. There are about 170 million HCV infected people in the world, and it is estimated that my country accounts for more than 40 million. Therefore, ...

AI Technical Summary

Problems solved by technology

Although their expression system is an edible plant, they did not use a compound polyepitope gene, which reduces the immunity of the product

[0010] At present, there is no expression of HCV compound multi-epitope antigen gene in edible plants