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Use of asafetida in the process for preparing anti-cancer medicament

The technology of a medicament and a dosage form is applied in the application field of asafoetida in the preparation of anti-cancer medicaments, and can solve the problems of difficulty in masking odor, application influence, etc.

Inactive Publication Date: 2007-08-08
王彦丁 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional use of Asafoetida is to directly use the original drug asafoetida as medicine. One is to boil it in water, and the other is to make pills or mix it with other medicines. It is difficult to cover up its special and strong odor, and the application is greatly affected.

Method used

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  • Use of asafetida in the process for preparing anti-cancer medicament
  • Use of asafetida in the process for preparing anti-cancer medicament
  • Use of asafetida in the process for preparing anti-cancer medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] The asafoetida volatile oil of the present invention is used to prepare an anticancer drug: cancer root injection, which is made by conventional methods.

[0137] Asafoetida volatile oil uses Xinjiang Asafoetida or Fukang Asafoetida as raw materials, and the usual oil-water separation method is used to prepare volatile oil. Measured in parts by weight, take 0.1-20 parts by weight of Asafoetida, add 0.1-80 parts of purified water, and perform steam distillation. The temperature is controlled at 105-108°C. The oil-water separator is used for separation, and 0.012-2.4 parts of volatile oil is collected. Asafoetida volatile oil.

[0138] Measure according to Table 6, add the volatile oil of Asafoetida to a solubilizer, such as 2,3-HP, β-CD, (the solubilizer is first dissolved by adding an appropriate amount of water for injection), stir for 20 minutes, add an appropriate amount of water for injection, and add isotonic regulator to chlorinate Sodium (sodium chloride for injectio...

Embodiment 2

[0143] The asafoetida volatile oil of the present invention is used to prepare anticancer drugs: cancer root capsules, which are made by conventional methods. Take 12kg of Asafoetida volatile oil, which is equivalent to 100kg Asafoetida. Take the excipient 47.74kg, that is, the weight ratio of ferulic volatile oil: excipient=1:3.98, of which starch 25kg, compressible starch 12kg, L-HPC 8kg, microcrystalline cellulose 2.5kg, CMS-Na 0.24 kg, put the excipients in the mixer, start to stir for 5 minutes, spray the asafoetida volatile oil evenly in the excipients, continue to stir for 5 minutes after spraying, add 5% starch slurry to make a soft material, put the soft material in In the granulator, wet granules are made through a stainless steel screen, dried at a temperature below 60°C into dry material, put into the granulator, after passing through the stainless steel screen, the granulation is placed in the mixer, and the lubricant stearic acid is added Magnesium 0.096kg, that is, ...

Embodiment 3

[0145] The asafoetida volatile oil of the present invention is used to prepare an anticancer drug: Aigen Dripping Pills (also known as Aigen Soft Capsules), which are made by conventional methods.

[0146] The volatile oil is extracted by steam distillation and separated by an oil-water separator to obtain 12 kg of asafoetida volatile oil, which is equivalent to 100 kg of asafoetida. (1) Preparation of gelatin liquid: gelatin:glycerin:water=1:0.4:1, take 7kg of gelatin, add 1.75kg of purified water to make it swell with water, take another 2.8kg of glycerin and 5.25kg of purified water and place it in a stainless steel tank and heat 75 Mix well at ℃, add expanded gelatin and stir to make it melt into a uniform solution, keep it for 1.5 hours, let it stand, remove the floating foam, filter with nylon cloth. (2) Preparation of medicinal liquid (i.e. oil liquid): Take 12 kg of the above-mentioned volatile oil, add 0.75 kg of medicinal peanut oil, and stir thoroughly. (3) Soft capsule...

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Abstract

The invention relates to a method for using asafetida to prepare the anti-tumor drug, which can be injection, capsule, tablet, or the like. The asafetida benzene mainly comprises a-firpene, a-terpinenes, terpin 4-alochol, pinocarveol, 2-bornyl alcohol, dimethyl disulfide, dimethyl trisulfide, N, N-thioformamide, and allyl-butyl-bisulfide. The invention uses general method to extract the asafetida benzene, as the gel resin of XinJiang asafetida or FuKang asafetida, or the like.

Description

Technical field: [0001] The invention relates to the pharmaceutical use of Asafoetida, the original traditional Chinese medicine medicine, or Asafoetida and its volatile oil produced in Iran, Afghanistan, Sri Lanka and other countries. Background technique: [0002] Asafoetida is a secretion of a natural plant. It is recorded on page 131 of the 2005 edition of Pharmacopoeia of the People’s Republic of China: Asafoetida is bitter, pungent and warm in nature, returning to the spleen and stomach meridian, eliminating accumulation, dispelling cold, and killing insects. Used for carnivorous stagnation, stasis, lumps in the abdomen, and abdominal pain due to worms. "National Compilation of Chinese Herbal Medicine" Volume 2 People's Medical Publishing House, 1978 page 318 records: Asafoetida is pungent in nature and taste, lukewarm, eliminates accumulation, insecticidal, dispels cold, mainly treats worm accumulation, abdominal lumps, stomach pain, malaria and dysentery It can also preve...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61P35/00
Inventor 王泽民
Owner 王彦丁
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