Use of asafetida volatile oil in preparing anticancer medicine

A technology of volatile oil and medicament, applied in the application field of ferulic volatile oil in the preparation of anti-cancer medicaments, can solve the problems of application influence, difficulty in masking odor and the like

Inactive Publication Date: 2008-11-19
王彦丁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional use of Asafoetida is to directly use the original drug asafoetida as medicine. One is to boil it in water, and the other is to make pills or mix it with other medicines. It is difficult to cover up its special and strong odor, and the application is greatly affected.

Method used

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  • Use of asafetida volatile oil in preparing anticancer medicine
  • Use of asafetida volatile oil in preparing anticancer medicine
  • Use of asafetida volatile oil in preparing anticancer medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] The ferula volatile oil of the present invention is used to prepare an anticancer drug: cancer root injection, which is prepared by a conventional method.

[0139] Ferulicum volatile oil uses Xinjiang Ferulicum or Fukang Ferulicum as raw materials, and adopts the usual oil-water separation method to prepare the volatile oil. Measured in parts by weight, take 0.1-20 parts by weight of Ferulicum, add 0.1-80 parts of purified water, carry out steam distillation, control the temperature at 105-108 ° C, separate through an oil-water separator, and collect 0.012-2.4 parts of volatile oil, that is Ferulic volatile oil.

[0140] Measured according to Table 6, add ferulicum volatile oil into a solubilizer, such as 2,3-HP, β-CD, (the solubilizer is first dissolved with an appropriate amount of water for injection) and stir for 20 minutes, then add an appropriate amount of water for injection, and add an isotonic regulator to chlorinate Sodium (sodium chloride for injection), add...

Embodiment 2

[0146] The ferulicum volatile oil of the present invention is used to prepare anticancer drug: cancer root capsule, which is prepared by conventional method. Take 12kg of Ferulicum volatile oil, which is equivalent to 100kg of Ferulicum. Get excipient 47.74kg, promptly weight ratio is Ferulicum volatile oil: excipient=1: 3.98, wherein, starch 25kg, compressible starch 12kg, L-HPC 8kg, microcrystalline cellulose 2.5kg, CMS-Na 0.24 kg, put the excipient in the mixer, start the machine and stir for 5 minutes, spray ferulic volatile oil evenly in the excipient, continue stirring for 5 minutes after spraying, add 5% starch slurry to make soft material, put the soft material in In the granulator, make wet granules through a stainless steel screen, dry them below 60°C to dry material, put them into the granulator, pass through the stainless steel screen for granulation, put them in a mixer, and add the lubricant stearic acid Magnesium 0.096kg, that is, excipient: lubricant = 1:0.002...

Embodiment 3

[0148] Ferulicum volatile oil of the present invention is used for preparing anticancer drug: cancer root dropping pill (has another name called cancer root soft capsule), adopts conventional method to make medicine.

[0149] The volatile oil is extracted by steam distillation, separated by an oil-water separator to obtain 12kg of Ferulicum volatile oil, which is equivalent to 100kg of Ferulicum. (1) Preparation of gelatin solution: gelatin: glycerin: water = 1:0.4:1, take 7kg of gelatin, add 1.75kg of purified water to make it absorb water and swell, take another 2.8kg of glycerin and 5.25kg of purified water and heat it in a stainless steel tank for 75 Mix evenly at ℃, add expanded gelatin and stir to make it melt into a uniform solution, keep warm for 1.5h, let stand, remove the floating foam, and filter with nylon cloth. (2) Preparation of medicinal liquid (ie oil liquid): take 12 kg of the above-mentioned volatile oil, add 0.75 kg of medicinal peanut oil, and stir well. ...

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Abstract

The invention is the application of resina ferulae volatile oil in preparing an anti-cancer preparation, relates to pharmaceutical uses of resina ferulae volatile oil of Chinese medicine and resina ferulae volatile oil abroad, and aims to provide a new use of the resina ferulae volatile oil. The resina ferulae volatile oil of the invention is used for preparing an anti-cancer preparation. The anti-cancer preparation can be preparations for injection, capsules, pills, tablets, granules, powders, oral liquid or other dosage forms. The resina ferulae volatile oil mainly contains: alfa-pinene, alfa-terpinenes, terpine 4-alcohol, D fenchyl alcohol, pinocarveol, 2-borneol, di-sec-butyl disulphide, sec-butyl- antiform-1-butenyl disulphide, sec-butyl- propenyl disulphide, dimethyl disulphide, dimethyl tersulfide, N.N-dimethyl thioformamide, propenyl-butyl-disulphide. The resina ferulae volatile oil is extracted from the resina ferulae by adopting the common extraction method. The resina ferulae can be oleo-gum-resin of Xinjiang resina ferulae or Fukang resina ferulae, as well as oleo-gum-resin of resina ferulae from Iran, Afghanistan, Sri Lanka, etc. The anti-cancer preparation prepared from the resina ferulae volatile oil is suitable for treating patients suffering from cancers.

Description

Technical field: [0001] The invention relates to the volatile oil of Ferulicum ferulae produced in Xinjiang, Fukang, or Iran, Afghanistan, Sri Lanka and other countries and the pharmaceutical use of Ferulicum ferulae volatile oil. Background technique: [0002] Asafoetida is a natural plant secretion. "Pharmacopoeia of the People's Republic of China" 2005 Edition, page 131 records: Ferulae is bitter, pungent, and warm in nature, returns to the spleen and stomach meridians, eliminates accumulation, dispels cold, and kills insects. Used for stagnation of meat, stagnation of blood in the abdomen, mass in the abdomen, and abdominal pain due to worm accumulation. "National Chinese Herbal Medicine Compilation" Volume 2, People's Health Publishing House, 1978, page 318 records: Ferulicum is pungent in nature and flavor, slightly warm, eliminates stagnation, kills insects, dispels cold, and treats mainly insect accumulation, abdominal mass, stomach and abdominal pain, malaria, dysen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61K9/20A61K9/48A61K9/10A61K9/16A61K9/14A61K9/06A61K9/08A61P35/00
Inventor 王泽民
Owner 王彦丁
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