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Gel preparation of Ciclopirox Olamine

The technology of ciclopirox amine gel and ciclopirox amine is applied in the directions of antifungal agents, active ingredients of heterocyclic compounds, sexual diseases, etc., and can solve the problems of short retention time, poor retention in the vagina, and easy to pollute clothes, etc. , to achieve the effect of feeling comfortable and smooth, improving bioabsorption and prolonging residence time

Inactive Publication Date: 2010-04-14
山东省医疗器械研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Yet solution is because its residence time in affected part is few, and drug action time is short, and curative effect is poor; Milk / ointment adopts oily base, has greasy feeling, is difficult to clean, and patient is inconvenient to use, and milk / ointment adopts more generally. Dispersed system, easy to stratify during storage, which affects the use and efficacy; and suppositories are easy to deteriorate due to the matrix, easy to deform at high temperature, poor retention in the vagina, and short drug action time, making it difficult to release all the drugs. There is a foreign body sensation, easy to damage the vaginal mucosa, easy to contaminate clothes after use, etc., and the use and efficacy of drugs are also seriously affected
[0010] At present, there is no report about ciclopirox olamine gel and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1. Prescription 1

[0037] Ciclopirox olamine 10g, carbomer 94010g, ethanol 100g, propylene glycol 300g, triethanolamine 28g, edetate disodium 0.5g, polysorbate 8020g, water was added to 1000g.

[0038] The preparation method is:

[0039] (1) Preparation of gel matrix

[0040]Weigh edetate disodium and add it to an appropriate amount of water, heat in a water bath, stir, and dissolve. Add the prescribed amount of propylene glycol and the rest of the water, then slowly add the prescribed amount of Carbomer 940 to the above solution while stirring, and stir thoroughly to make the swelling and dispersion uniform; drop triethanolamine, stir evenly, and form a gel matrix ;

[0041] (2) Preparation of liquid medicine

[0042] Get the raw material medicine of prescription quantity, add the ethanol of prescription quantity and polysorbate 80, put in the warm water bath and heat to dissolve;

[0043] (3) Preparation of gel

[0044] Add the medicinal solution dro...

Embodiment 2

[0045] Embodiment 2. Prescription 2

[0046] Ciclopirox olamine 10g, carbomer 94010g, ethanol 100g, propylene glycol 300g, triethanolamine 13g, edetate disodium 0.5g, polysorbate 8020g, water to 1000g.

[0047] Preparation method is the same as embodiment 1

Embodiment 3

[0048] Embodiment 3. Prescription 3

[0049] Ciclopirox olamine 10g, carbomer 94010g, ethanol 150g, propylene glycol 350g, triethanolamine 5g, edetate disodium 0.5g, polysorbate 8040g, water was added to 1000g.

[0050] Preparation method is the same as embodiment 1

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PUM

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Abstract

A gel medicine containing ciclopirox olamine for skin and vagina is proportionally prepared from ciclopirox olamine, carbomer, alcohol, propanediol, triethanolamine, bisodium versenate, polysorbide, and water. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, more specifically, it belongs to the gel preparation of ciclopirox olamine. Background technique [0002] Dermatomycosis is a kind of very common skin disease, mainly occurs in southern China, and according to domestic literature reports, its prevalence rate is as high as 58.59%; High, sometimes causing small area acute transmission. It can be seen that the incidence of dermatophytosis is very extensive in my country. Therefore, research on new antifungal drugs is extremely important. [0003] In addition, candidal vaginitis, also known as candidal vaginosis, is also called fungal vaginitis, which is one of the most commonly infected diseases in adult women. There are millions of women suffering from candidal vaginitis all over the world. In the United States, candidal vaginitis is second only to bacterial vaginosis, ranking second, which is 4 times that of trichomonas vaginitis. Ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/44A61K47/10A61K47/18A61P15/02A61P17/00A61P31/10
Inventor 杨清华刘富强王传栋刘裕
Owner 山东省医疗器械研究所
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