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Composition containing sugar-reducing medicine and antiplatelet medicine

A technology of anti-platelet drugs and compositions, which is applied in the field of medicine and can solve problems such as high risk of disease

Inactive Publication Date: 2007-11-14
深圳市奥萨药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional treatment methods often only intervene based on a relatively high level of risk factors, but from some large-scale prospective studies such as Framingham Heart Study, Multiple Risk Factor Intervention Trial , MRFTT) and the Prospective Cardiovascular Münster study (Prospective Cardiovascular Münster study, PROCAM), it can be seen that the occurrence of cardiovascular disease rarely depends on a single factor; Much higher than the sum of the effects of a single risk factor; at the same time, individuals with multiple risk factors, although the level of each risk factor is only slightly elevated, have a higher risk than individuals with only one very high level of risk factor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of Compound Pioglitazone Aspirin Tablets (1000 Tablets)

[0050] Recipe: pioglitazone 15g

[0051] Aspirin 75g

[0052] Starch 50g

[0053] Microcrystalline Cellulose 50g

[0054] Sodium Carboxymethyl Starch 20g

[0055] Low Substituted Hydroxypropyl Cellulose 20g

[0056] Povidone ethanol solution

[0057] Magnesium Stearate 1%

[0058]Preparation method: pulverize the raw and auxiliary materials through an 80-mesh sieve, and dry for use. Take 15g of pioglitazone and 75g of aspirin and mix them uniformly according to the equal increment method. Add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose respectively according to the recipe, and mix them evenly by the equal increment method. Use 5 % Povidone K29 / 30-95% ethanol solution is made into soft material, granulated with 20 mesh sieve, dried at 40°C for about 2 hours, granulated with 18 mesh sieve, and the moisture content of the ...

Embodiment 2

[0059] Example 2 Preparation of Compound Acarbose Aspirin Tablets (1000 Tablets)

[0060] Recipe: Acarbose 100g

[0061] Aspirin 75g

[0062] Starch 100g

[0063] Microcrystalline Cellulose 50g

[0064] Sodium Carboxymethyl Starch 20g

[0065] Low Substituted Hydroxypropyl Cellulose 20g

[0066] Povidone ethanol solution

[0067] Magnesium Stearate 1%

[0068] The preparation method is the same as that in Example 1, and each of the prepared compound tablets contains 100 mg of acarbose and 75 mg of aspirin, and the mass ratio thereof is 4:3.

Embodiment 3

[0069] Example 3 Preparation of Compound Metformin and Clopidogrel Tablets (1000 Tablets)

[0070] Formula: Metformin 500g

[0071] Clopidogrel 75g

[0072] Starch 100g

[0073] Microcrystalline Cellulose 50g

[0074] Sodium Carboxymethyl Starch 20g

[0075] Low Substituted Hydroxypropyl Cellulose 20g

[0076] Povidone ethanol solution

[0077] Magnesium Stearate 1%

[0078] The preparation method is the same as that in Example 1, and each of the prepared compound tablets contains 500 mg of metformin and 75 mg of clopidogrel, and the mass ratio thereof is 20:3.

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PUM

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Abstract

The present invention relates to a medicine composition containing hypoglycemic medicine (mainly including thiazolidione, biquanide or alpha-glycosidase inhibitor) and antiplatelet medicine (mainly including aspirin or clopidogrel). Said medicine composition contains hypoglycemic medicine or its medicinal salt with effective dose and medicinal carrier or excipient. Said invention also provides the application of said medicine composition in preparation of medicine for curing the diseases of hypertension, diabetes, inflammation and atherosclerosis, etc.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing hypoglycemic drugs and antiplatelet drugs, and the preparation of the composition for the treatment of hypertension, dyslipidemia, diabetes, abnormal coagulation state, inflammation, endothelial cell dysfunction, atherosclerosis or the above Use in a medicament for a combination of two or more diseases of a disease. The present invention belongs to the field of medicine. Background technique [0002] Atherosclerotic cardiovascular disease (ACVD) is the number one killer in developed countries and is increasingly common in developing countries. ACVD mainly includes coronary heart disease (CHD), stroke and peripheral arterial disease. The mechanism of ACVD may be related to lipid infiltration, platelet aggregation, endothelial injury, inflammatory response, etc. So far, 246 risk factors have been identified, among which The main and recognized risk factors are hypertension, hyperl...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/155A61K31/4436A61K31/616A61K31/70A61K9/20A61K9/22A61K9/48A61K9/08A61P3/10A61P3/06A61P7/02A61P9/12A61P9/10
Inventor 秦献辉王文艳戴成祥徐希平
Owner 深圳市奥萨药业有限公司
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