Penetration-promoting type catablasm matrix and preparation method thereof

A matrix, glycerin technology, applied in the direction of pharmaceutical formulations, inactive medical preparations, sheet delivery, etc., can solve the problems of poor skin penetration, small drug load, adhesion to hair, etc., to reduce risks, improve Adaptive, safety-enhancing effects

Inactive Publication Date: 2007-11-28
天津宝康科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, traditional plasters (soft plasters, black plasters) are based on fat-soluble materials, which have serious defects in application, such as small drug load, poor transdermal performance, allergies, rashes, adhesion of hair, contamination of clothes, etc. Its use is very limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Prescription ratio:

[0033] Glycerin 18g Carboresin 1.5g Gelatin 1.5g

[0034] Indian gum 3.5g ethanol 0.6g camphor 0.1g

[0035] Laurocaprazine 0.2g Sodium hydroxide 0.5g Purified water 15.0g

[0036] Preparation:

[0037] Add carbomer resin to glycerin and stir to pass, then add gelatin and stir until completely mixed to obtain phase I; dissolve vegetable gum in an appropriate amount of hot distilled water or deionized water, add a stirrer and mix evenly with phase I to obtain phase II; Add appropriate amount of sodium into distilled water or deionized water, dissolve completely, add phase II, and obtain phase III after the reaction is complete; add camphor and laurocaprazine into ethanol and dissolve completely, then add phase III to obtain the cataplasm matrix.

Embodiment 2

[0039] Prescription ratio:

[0040] Glycerin 30g Carboresin 1.8g Gelatin 2.5g

[0041] Gum Arabic 1.2g Ethanol 1.2g Camphor 0.5g

[0042] Laurocaprazine 0.5g Sodium hydroxide 0.8g Purified water 35.0g

[0043] Preparation:

[0044] Add carbomer resin to glycerin and stir to pass, then add gelatin and stir until completely mixed to obtain phase I; dissolve vegetable gum in an appropriate amount of hot distilled water or deionized water, add a stirrer and mix evenly with phase I to obtain phase II; Add appropriate amount of sodium into distilled water or deionized water, dissolve completely, add phase II, and obtain phase III after the reaction is complete; add camphor and laurocaprazine into ethanol and dissolve completely, then add phase III to obtain the cataplasm matrix.

Embodiment 3

[0046] Prescription ratio:

[0047] Glycerin 22g Carboresin 2.5g Gelatin 4.5g

[0048] Maple Gum 2.5g Ethanol 2.5g Camphor 1.2g

[0049] Laurocaprazine 0.7g Sodium hydroxide 1g Purified water 25.0g

[0050] Preparation:

[0051] Add carbomer resin to glycerin and stir to pass, then add gelatin and stir until completely mixed to obtain phase I; dissolve vegetable gum in an appropriate amount of hot distilled water or deionized water, add a stirrer and mix evenly with phase I to obtain phase II; Add appropriate amount of sodium to distilled water or deionized water, dissolve completely, add phase II, and obtain phase III after complete reaction; add camphor and azone into ethanol, dissolve completely, then add phase III to obtain the cataplasm matrix.

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PUM

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Abstract

The present invention discloses one kind of permeation promoting matrix for plaster and its preparation process. The permeation promoting matrix consists of glycerin 18-30 weight portions, carfobol resin 1.5-4 weight portions, vegetable gum 0.5-3.5 weight portions, gelatin 1-4.5 weight portions, distilled water or deionized water 10-36 weight portions, sodium 0.1-2.4 weight portions, alcohol 0.6-3.6 weight portions, camphor 0.1-2 weight portions, laurocapram 0.2-1 weight portions. The permeation promoting matrix of the present invention has great medicine carrying capacity, high transdermal effect, high air permeability, high affinity to various kinds of medicine, comfort, stable property and other advantages, and is suitable for industrial production of Chinese and Western medicine plasters.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a permeation-enhancing cataplasm base and a preparation method thereof. Background technique [0002] The concept of cataplasms originated in Europe and Japan in the 1960s and 1970s. At that time, the medical circles in Europe and Japan were all committed to improving traditional external patches, and tried to develop a drug that contained large amounts of drugs, good transdermal effects, and medicinal properties. It is an ideal topical drug delivery platform with five characteristics of controllable ingredients, slow release, good air permeability, and no irritation to the skin. Therefore, the Japanese medical community calls this concept product a cataplasm. [0003] In the mid-1970s, Japan first claimed to have developed a cataplasm, which was used in "diced peppers" in the 1980s, but its real product did not meet the requirements of an ideal cataplasm. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/46
Inventor 马秀奎
Owner 天津宝康科技发展有限公司
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