Penetration-promoting type catablasm matrix and preparation method thereof
A matrix, glycerin technology, applied in the direction of pharmaceutical formulations, inactive medical preparations, sheet delivery, etc., can solve the problems of poor skin penetration, small drug load, adhesion to hair, etc., to reduce risks, improve Adaptive, safety-enhancing effects
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Embodiment 1
[0032] Prescription ratio:
[0033] Glycerin 18g Carboresin 1.5g Gelatin 1.5g
[0034] Indian gum 3.5g ethanol 0.6g camphor 0.1g
[0035] Laurocaprazine 0.2g Sodium hydroxide 0.5g Purified water 15.0g
[0036] Preparation:
[0037] Add carbomer resin to glycerin and stir to pass, then add gelatin and stir until completely mixed to obtain phase I; dissolve vegetable gum in an appropriate amount of hot distilled water or deionized water, add a stirrer and mix evenly with phase I to obtain phase II; Add appropriate amount of sodium into distilled water or deionized water, dissolve completely, add phase II, and obtain phase III after the reaction is complete; add camphor and laurocaprazine into ethanol and dissolve completely, then add phase III to obtain the cataplasm matrix.
Embodiment 2
[0039] Prescription ratio:
[0040] Glycerin 30g Carboresin 1.8g Gelatin 2.5g
[0041] Gum Arabic 1.2g Ethanol 1.2g Camphor 0.5g
[0042] Laurocaprazine 0.5g Sodium hydroxide 0.8g Purified water 35.0g
[0043] Preparation:
[0044] Add carbomer resin to glycerin and stir to pass, then add gelatin and stir until completely mixed to obtain phase I; dissolve vegetable gum in an appropriate amount of hot distilled water or deionized water, add a stirrer and mix evenly with phase I to obtain phase II; Add appropriate amount of sodium into distilled water or deionized water, dissolve completely, add phase II, and obtain phase III after the reaction is complete; add camphor and laurocaprazine into ethanol and dissolve completely, then add phase III to obtain the cataplasm matrix.
Embodiment 3
[0046] Prescription ratio:
[0047] Glycerin 22g Carboresin 2.5g Gelatin 4.5g
[0048] Maple Gum 2.5g Ethanol 2.5g Camphor 1.2g
[0049] Laurocaprazine 0.7g Sodium hydroxide 1g Purified water 25.0g
[0050] Preparation:
[0051] Add carbomer resin to glycerin and stir to pass, then add gelatin and stir until completely mixed to obtain phase I; dissolve vegetable gum in an appropriate amount of hot distilled water or deionized water, add a stirrer and mix evenly with phase I to obtain phase II; Add appropriate amount of sodium to distilled water or deionized water, dissolve completely, add phase II, and obtain phase III after complete reaction; add camphor and azone into ethanol, dissolve completely, then add phase III to obtain the cataplasm matrix.
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