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Dexibuprofen granule and preparation method thereof

A kind of granules and appropriate amount of technology, applied in the field of medicine, can solve the problems that it is difficult to make soluble liquid dosage forms, difficult to prepare granules for insoluble drugs, etc., and achieve the effect of simple and reliable preparation method, low cost and convenient administration

Inactive Publication Date: 2010-06-30
蚌埠丰原涂山制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to solve the shortcomings of the dextrobuprofen oral preparations in the prior art: it is difficult to make a soluble liquid dosage form in water and difficult to prepare granules for insoluble drugs, and a kind of dextrobuprofen is proposed. Profen granule and preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prescription: Dexibuprofen 200

[0028] Arginine 385

[0029] Lactose 785

[0030] Polyethylene glycol PEG 100

[0031] Appropriate amount of lubricant

[0032] Appropriate amount of stevioside and spices

[0033] Proper amount of ethanol or water

[0034] Process: Crushing, mixing, granulating and packaging the above raw and auxiliary materials.

Embodiment 2

[0036] Prescription: Dexibuprofen 200

[0037] Arginine hydrochloride 385

[0038] Sucrose 785

[0039] Polyvinylpyrrolidone PVP 100

[0040] Appropriate amount of lubricant

[0041] Appropriate amount of stevioside and spices

[0042] Proper amount of ethanol or water

[0043] Process: Crushing, mixing, granulating and packaging the above raw and auxiliary materials.

Embodiment 3

[0045] Prescription: Dexibuprofen 200

[0046] Lysine 385

[0047] Mixture of lactose and sucrose 675

[0048] Polyvinylpyrrolidone PVP 80

[0049] Appropriate amount of lubricant

[0050] Appropriate amount of stevioside and spices

[0051] Proper amount of ethanol or water

[0052] Process: Crushing, mixing, granulating and packaging the above raw and auxiliary materials.

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Abstract

The present invention discloses one kind of dextro brufen granule and its preparation process, and features that the dextro brufen granule contains dextro brufen 1 weight portions, alkaline cosolvent 0-100 weight portions, stuffing 0.1-100 weight portions, adhesive 0.1-12 weight portions, corrective 0.01-0.5 weight portion, and lubricant 0.1-2 weight portions. Its preparation process includes thesteps of mixing, pelletizing and packing. The effervescent dextro brufen tablet is superior to traditional orally taken dextro brufen preparation, can dissolve in water to form tasty solution, and has easy taking, high bioavailability, fast acting and other advantages.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and in particular relates to a dextroibuprofen granule for treating pain and fever caused by various reasons and a preparation method thereof. Background technique [0002] Ibuprofen, namely 2-(4-isobutylphenyl) propionic acid, is a non-steroidal anti-inflammatory drug (NSAIDs), is the first ibuprofen drug used clinically and is still widely used in the world. It is recognized as one of the safest drugs among NSAIDs. Pharmacological action shows its anti-inflammatory, analgesic and antipyretic effects. Clinically used for various acute and chronic arthritis, soft tissue rheumatism, tenosynovitis, sports injuries and headaches, myalgia, dysmenorrhea, pain after tooth extraction, and cancer pain. The drug is recommended as the first step drug in the analgesic drug ladder [2], which is recorded in domestic and foreign pharmacopoeias and is one of the basic drugs in my country [0003] Due to th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/40A61K47/10A61P29/00A61P19/02A61K9/16A61K31/192A61K47/16A61K47/26
Inventor 汪洋
Owner 蚌埠丰原涂山制药有限公司
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