Heart-benefiting Yixinshu micropill and its prepn process

A technology of Yixinshu pellets and microcrystalline cellulose, which is applied in the directions of pill delivery, cardiovascular system diseases, and medical preparations containing active ingredients, etc. Mildew and other problems, to achieve the effect of excellent disintegration and solubility, good taste and low hygroscopicity

Inactive Publication Date: 2007-12-19
葛浩斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned problems that the contents of Yixinshu capsules are easy to absorb moisture and soften, agglomerate and mildew, prolong the disintegration time, and have poor stability, the present invention provides a kind of Yixinshu pellets, and the present invention also provides the Yixinshu Preparation process of pellets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The parts by weight of each component in the formula adopted in the present embodiment are as follows:

[0023] Ginseng 300;

[0024] Ophiopogon japonicus 300;

[0025] Schisandra 200;

[0026] Astragalus 300;

[0027] Danshen 400;

[0028] Chuanxiong 200;

[0029] Hawthorn 300.

[0030] The present embodiment provides the preparation method of Yixinshu pellets as follows:

[0031] 1) the ginseng powder of said amount is finely powdered, for subsequent use;

[0032] 2) Put the amount of Schisandra Fructus and Danshen into 8 times the volume of 85% ethanol for reflux extraction twice, the first time for 3 hours, the second time for 1.5 hours, filter, and the filtrate reclaims ethanol and concentrates to a relative density of 1.10-1.35 ( 20 ℃) ​​clear ointment, spare;

[0033] 3) Add 8 times the volume of Ophiopogon japonicus, Radix Astragali, Chuanxiong, and Hawthorn to decoct twice, the first time for 2.5 hours, the second time for 1.5 hours, combine the filtrat...

Embodiment 2

[0042] The parts by weight of each component in the formula adopted in the present embodiment are as follows:

[0043] Ginseng 300;

[0044] Ophiopogon japonicus 300;

[0045] Schisandra 200;

[0046] Astragalus 300;

[0047] Danshen 400;

[0048] Chuanxiong 200;

[0049] Hawthorn 300.

[0050] The present embodiment provides the preparation method of Yixinshu pellets as follows:

[0051] 1) the ginseng powder is made into fine powder, and set aside;

[0052] 2) Put the amount of Schisandra chinensis and Danshen root into 6 times the volume of 85% ethanol for reflux extraction, filter, recover ethanol from the filtrate and concentrate it to a clear paste with a relative density of 1.10 (20° C.), and set aside;

[0053] 3) Add 6 times the volume of Ophiopogon japonicus, Radix Astragali, Rhizoma Chuanxiong, and Hawthorn to decoct, filter the decoction, add an equivalent amount of 85% ethanol, stir well, and let it stand overnight to obtain an alcoholic liquid;

[0054] 4...

Embodiment 3

[0062] The parts by weight of each component in the formula adopted in the present embodiment are as follows:

[0063] Ginseng 100;

[0064] Ophiopogon japonicus 500;

[0065] Schisandra 100;

[0066] Astragalus 450;

[0067] Danshen 200;

[0068] Chuanxiong 300;

[0069] Hawthorn 200.

[0070] The present embodiment provides the preparation method of Yixinshu pellets as follows:

[0071] 1) the ginseng powder of said amount is finely powdered, and set aside;

[0072] 2) Put the amount of Schisandra chinensis and Danshen root into 8 times the volume of 85% ethanol for reflux extraction, filter, recover ethanol from the filtrate and concentrate it to a clear paste with a relative density of 1.15 (20° C.), and set aside;

[0073] 3) Add 8 times the volume of Ophiopogon japonicus, Radix Astragali, Rhizoma Chuanxiong, and Hawthorn to decoct, filter the decoction, add an equivalent amount of 85% ethanol, stir thoroughly, and let it stand overnight to obtain an alcoholic liqu...

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Abstract

The present invention is heart-benefiting Yixinshu micropill and its preparation process. The heart-benefiting Yixinshu micropill is prepared with ginseng 100-500 weight portions, ophiopogon root 100-500weight portions, schisandra 100-300weight portions, astragalus root 150-450weight portions, red sage 200-600weight portions, Chuanxiong rhizome 100-300weight portions, haw 200-400weight portions, avicel 300-500weight portions, and mannitol 50-200weight portions. It has diameter smaller than 0.05mm, excellent disintegrating and dissolving performance, fast acting, high bioavailability, and other advantages, and possesses functions of promoting blood circulation to disperse blood clots, benefiting qi, nourishing yin, etc.

Description

technical field [0001] The invention relates to a pellet preparation and a preparation process thereof, in particular to a Yixinshu pellet and a preparation process thereof. Background technique [0002] The Yixinshu Capsules currently on the market are standard Chinese medicine ingredients (standard number: WS 3 -b-2620-97), has the effects of nourishing qi and restoring pulse, promoting blood circulation and removing blood stasis, nourishing yin and promoting body fluid. It is used for patients with Qi and Yin deficiency, myocardial pulse knots, chest tightness, chest pain and angina pectoris of coronary heart disease. [0003] Yixinshu Capsule formula is as follows: 150g ginseng, 150g Ophiopogon japonicus, 100g Schisandra chinensis, 150g astragalus, 200g salvia miltiorrhiza, 100g Chuanxiong, 150g hawthorn. The preparation method of Yixinshu Capsules is as follows: the above seven flavors are taken from ginseng and crushed into fine powder for later use. Schisandra chin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/20A61P9/10
Inventor 葛浩斌梁起臣
Owner 葛浩斌
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