Detection method of medicament for treating angina pectoris

A technology for coronary heart disease angina pectoris and a detection method, which is applied in the field of medicine, can solve the problem of not examining the content of ginsenosides, etc., and achieves the effects of excellent disintegration and solubility, easy to carry, and easy to take.

Inactive Publication Date: 2012-11-07
梁丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the existing detection method of Yixinshu Capsules, ginsenoside Re(C 48 h 82 o 18 ) content

Method used

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  • Detection method of medicament for treating angina pectoris
  • Detection method of medicament for treating angina pectoris
  • Detection method of medicament for treating angina pectoris

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The parts by weight of each component in the formula adopted in the present embodiment are as follows:

[0052] Ginseng 300;

[0053] Ophiopogon japonicus 300;

[0054] Schisandra 200;

[0055] Astragalus 300;

[0056] Danshen 400;

[0057] Chuanxiong 200;

[0058] Hawthorn 300.

[0059] The present embodiment provides the preparation method of Yixinshu pellets as follows:

[0060] (1) the ginseng powder of described amount is made fine powder, for subsequent use;

[0061] (2) Put the schisandra chinensis and Danshen root into 8 times the volume of 85% ethanol for reflux extraction twice, the first time for 3 hours, the second time for 1.5 hours, filter, and the filtrate reclaims ethanol and concentrates to a relative density of 1.10-1.35 (20°C) clear ointment, set aside;

[0062] (3) Decoct the described amount of Ophiopogon japonicus, Radix Astragali, Rhizoma Chuanxiong, and Hawthorn with 8 times the volume of water, for the first time for 2.5 hours, and for t...

Embodiment 2

[0071] The parts by weight of each component in the formula adopted in the present embodiment are as follows:

[0072] Ginseng 300;

[0073] Ophiopogon japonicus 300;

[0074] Schisandra 200;

[0075] Astragalus 300;

[0076] Danshen 400;

[0077] Chuanxiong 200;

[0078] Hawthorn 300.

[0079] The present embodiment provides the preparation method of Yixinshu pellets as follows:

[0080] (1) described ginseng powder is made into fine powder, for subsequent use;

[0081] (2) adding the Schisandra chinensis and Danshen root into 6 times the volume of 85% ethanol for reflux extraction, filtering, reclaiming ethanol from the filtrate and concentrating it to a clear paste with a relative density of 1.10 (20° C.), for subsequent use;

[0082] (3) Add 6 times the volume of Ophiopogon japonicus, Radix Astragali, Rhizoma Chuanxiong, and Hawthorn to decoct, filter the decoction, add an equivalent amount of 85% ethanol, stir well, and let it stand overnight to obtain alcoholic li...

Embodiment 3

[0091] The parts by weight of each component in the formula adopted in the present embodiment are as follows:

[0092] Ginseng 100;

[0093] Ophiopogon japonicus 500;

[0094] Schisandra 100;

[0095] Astragalus 450;

[0096] Danshen 200;

[0097] Chuanxiong 300;

[0098] Hawthorn 200.

[0099] The present embodiment provides the preparation method of Yixinshu pellets as follows:

[0100] (1) the ginseng powder of described amount is made fine powder, for subsequent use;

[0101] (2) adding the Schisandra chinensis and Danshen root into 8 times the volume of 85% ethanol for reflux extraction, filtering, reclaiming the ethanol from the filtrate and concentrating it to a clear paste with a relative density of 1.15 (20° C.), for subsequent use;

[0102] (3) Add 8 times the volume of Ophiopogon japonicus, Radix Astragali, Rhizoma Chuanxiong, and Hawthorn to decoct, filter the decoction, add an equivalent amount of 85% ethanol, stir well, and let stand overnight to obtain al...

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Abstract

The invention provides a detection method of a medicament for treating angina pectoris. According to the detection method, ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 in the medicament are detected by high performance liquid chromatography. Conditions of the high performance liquid chromatography comprise: octadecylsilane bonded silica gel is used as a chromatographic column for a filler; and an acetonitrile solution is used as a mobile phase A and water is used as a mobile phase B for gradient elution. The gradient elution process is as follows: during the first 25 minutes, the mobile phase A acetonitrile solution is 15% by volume and the mobile phase B water is 85% by volume; from the 25th minute to the 70th minute, the mobile phase A acetonitrile solution is 15-22% by volume and the mobile phase B water is 85-78% by volume; from the 70th minute to the 80th minute, the mobile phase A acetonitrile solution is 22-30% by volume and the mobile phase B water is 78-70% by volume; from the 80th minute to 105th minute, the mobile phase A acetonitrile solution is 30-40% by volume and the mobile phase B water is 70-60% by volume; and from the 105th minute to 120th minute, the mobile phase A acetonitrile solution is 40-15% by volume and the mobile phase B water is 60-85% by volume.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a detection method of a medicine for treating coronary heart disease and angina pectoris. Background technique [0002] Cardiovascular disease is one of the four diseases with the highest incidence rate, among which coronary heart disease and angina pectoris are more common. There is a higher incidence in the elderly population. As my country enters an aging society, the demand for such therapeutic drugs is also increasing. [0003] Yixinshu Capsules (standard number: WS 3 -b-2620-97) has a good curative effect in the treatment of coronary heart disease angina pectoris. The formula is as follows: 150g ginseng, 150g Ophiopogon japonicus, 100g Schisandra chinensis, 150g astragalus, 200g salvia miltiorrhiza, 100g Chuanxiong, and 150g hawthorn. The preparation method is as follows: for the above seven flavors, take ginseng and grind it into fine powder for later use....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02A61K36/8968A61P9/10
Inventor 梁起臣梁小平
Owner 梁丽
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