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Externally- used contraception emulsion and method for preparing the same

The technology of an emulsion agent and an emulsion stabilizer is applied in the field of external contraceptive emulsion and its preparation, which can solve the problems such as the lack of data in the patent, and achieve the effects of protecting the vaginal epithelium and mucous membranes, being easy to industrialize production and having simple varieties.

Inactive Publication Date: 2008-02-06
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As for whether the latex has a contraceptive effect, the above-mentioned patent has no data to suggest

Method used

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  • Externally- used contraception emulsion and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]① Carbopol 934 5%

[0026] ② Beeswax 10%

[0027] ③ Tween 80 5%

[0028] ④ Macrogol 400 5%

[0029] ⑤Water 75%

[0030] Preparation:

[0031] Dissolve Carbopol 934 and Tween 80 in water, heat up to 60°C and keep it warm to make a water phase; mix beeswax and polyethylene glycol 400 and heat to 60°C, melt and keep warm to form an oil phase; pour the above oil phase Pour into the water phase, stir and mix well, and it will be latex after cooling down. If necessary, adjust the pH to 3 with NaOH.

Embodiment 2

[0033] ① Carbopol 934 1%

[0034] ② Vaseline 0.5%

[0035] ③Sucrose Ester 0.1%

[0036] ④Hydrogenated vegetable oil 25%

[0037] ⑤ Benzoic acid 1%

[0038] ⑥Water 72.4%

[0039] Preparation:

[0040] Dissolve benzoic acid in water at 60-85°C, let it cool to room temperature, add Carbopol 934 and stir evenly, heat up to 60°C and keep it warm to make a water phase; mix petrolatum, sucrose ester, and hydrogenated vegetable oil and heat to 60°C, melt , Insulation is the oil phase; pour the oil phase into the water phase, stir and mix well, it will be latex after cooling, and adjust the pH to 4 with NaOH if necessary.

Embodiment 3

[0042] ①Carbopol 974 3%

[0043] ②Lanolin 5%

[0044] ③Emulsifier OP 2.5%

[0045] ④ Glycerin 15%

[0046] ⑤ Methylparaben 0.18%

[0047] ⑥ Propylparaben 0.02%

[0048] ⑦Water 74.3%

[0049] Preparation:

[0050] Dissolve methylparaben and propylparaben in water at 60-85°C, let cool to room temperature, add Carbopol 974 and stir evenly, heat up to 60°C and keep warm to make a water phase; lanolin, emulsifier OP and glycerin are mixed and heated to 60°C, melted and kept warm to form an oil phase; pour the oil phase into the water phase, stir and mix well, let it cool to form latex, and adjust the pH to 3.5 with NaOH if necessary.

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PUM

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Abstract

The invention discloses an external application contraception emulsion, which comprises water phase and oil phase, wherein the water phase contains biological adhesive used as active constitutent. The invention is characterized in that: the biological adhesive is polycarboxylic vinyl polymer carbomer with the weight percentage inside gel being 1 percent to 5 percent. The type of polymer in the emulsion is simple and functions such as forming framework, biological adhesion and keeping natural shelter of vagina are obtained by use of just one type of polycarboxylic vinyl polymer, i.e. carbomer; meanwhile, functions of fixing sperm and restricting and killing activity of sperm for contraception as well as prevention of sexually transmitted diseases can be obtained without adopting other active components of medicine; moreover, the invention has simple manufacturing technique, thereby being easy to realize industrialized production.

Description

technical field [0001] The invention relates to a contraceptive medicine for external use, in particular to a contraceptive emulsion for external use and a preparation method thereof. Background technique [0002] At present, the most widely used contraceptive drug at home and abroad is nonoxynol-9 (N-9). N-9 is a kind of surfactant. Or lead to the inability of sperm to move, thereby preventing it from entering the cervix, unable to fertilize the egg, and achieving the purpose of contraception. While N-9 is an effective external contraceptive, it should also be noted that it is also a strong cytotoxic agent, which has non-specific damage to the cell membrane of the body. Clinical studies have confirmed that the epithelium of the vagina and cervix will rupture at the concentration usually present in vaginal contraceptives (generally greater than 3% N-9); N-9 will also destroy the normal vaginal flora, and the presence of these flora can make the vagina Maintain a stable aci...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/34A61P15/16A61K47/10A61K47/26A61K47/32
Inventor 陈庆华包泳初瞿挺潘峰郭红星肖莉莉吴莹
Owner SHANGHAI INST OF PHARMA IND
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