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Chitosan contraceptive gel and preparation method thereof

A chitosan and gel technology, applied in pharmaceutical formulations, drug delivery, sexually transmitted diseases, etc., can solve problems such as damage to the reproductive tract mucosa, low incidence of allergies, and damage to the vaginal environment, maintaining natural barriers and low allergy rates. , the effect of preventing infection

Inactive Publication Date: 2010-11-24
林一文 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to overcome the defect that the existing vaginal gel composition destroys the vaginal environment and damages the reproductive tract mucosa, and provides a vaginal gel composition with a pH value similar to that of the vaginal environment, less irritation, and a lower incidence of allergies. Chitosan Contraceptive Gel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A chitosan contraceptive gel consisting of 1% chitosan, 1% carbomer, 2% triethanolamine, 20% ethanol, 10% propylene glycol, 0.5% benzalkonium chloride, 1% glycerin, 1% citric acid , 1% polyethylene glycol 400, 0.5% benzalkonium bromide, 0.2% ethylparaben, 0.2% methylparaben and the balance of purified water components. Its preparation method is:

[0020] 1) Sprinkle 1.0% chitosan and 1.0% carbomer on the liquid surface of purified water, and after overnight, it will become a gel matrix, and vacuum degassing after standing;

[0021] 2) Mix 2.0% triethanolamine with 20% ethanol, 10% propylene glycol, 0.5% benzalkonium chloride, 1.0% glycerin, 1.0% citric acid, 1.0% polyethylene glycol 400, 0.5% benzalkonium bromide, 0.2% Ethylparaben and 0.2% methylparaben are mixed evenly, and gradually added into the gel matrix and mixed evenly, so that the chitosan contraceptive gel can be prepared.

Embodiment 2

[0023] A chitosan contraceptive gel consisting of 0.5% chitosan, 1.5% carbomer, 3.0% triethanolamine, 30% ethanol, 20% propylene glycol, 1.0% benzalkonium chloride, 2.0% glycerin, 2.0% citric acid , 2.0% polyethylene glycol 400, 1.0% benzalkonium bromide, 0.5% ethylparaben, 0.5% methylparaben and the balance of purified water components. Its preparation method is:

[0024] 1) Sprinkle 0.5% chitosan and 1.5% carbomer on the liquid surface of purified water, and after overnight, it will become a gel matrix, and vacuum degassing after standing;

[0025] 2) Mix 3.0% triethanolamine with 30% ethanol, 20% propylene glycol, 1.0% benzalkonium chloride, 2.0% glycerin, 2.0% citric acid, 2.0% polyethylene glycol, 1.0% benzalkonium bromide and 0.5% nitric acid Ethyl parkinate is mixed evenly, and then gradually added into the gel matrix and mixed evenly to obtain chitosan contraceptive gel.

Embodiment 3

[0027] A chitosan contraceptive gel consisting of 1.5% chitosan, 0.5% carbomer, 1.0% triethanolamine, 10% ethanol, 5% propylene glycol, 1.0% benzalkonium chloride, 2.0% glycerin, 2.0% citric acid , 2.0% polyethylene glycol, 1.0% benzalkonium bromide, 0.5% ethylparaben and the balance of purified water components. Its preparation method is:

[0028] 1) Sprinkle 1.5% chitosan and 0.5% carbomer on the liquid surface of purified water, and after overnight, it will become a gel matrix, and vacuum degassing after standing;

[0029] 2) Mix 1.0% triethanolamine with 10% ethanol, 5% propylene glycol, 1.0% benzalkonium chloride, 2.0% glycerin, 2.0% citric acid, 2.0% polyethylene glycol, 1.0% benzalkonium bromide and 0.5% nitric acid Ethyl parkinate is mixed evenly, and then gradually added into the gel matrix and mixed evenly to obtain chitosan contraceptive gel.

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PUM

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Abstract

The invention relates to a chitosan contraceptive gel and a preparation method thereof. The contraceptive gel consists of 0.5 to 1.5 percent of chitosan, 0.5 to 1.5 percent of carbomer, 0.5 to 3.0 percent of triethanolamine, 10 to 30 percent of ethanol, 5 to 20 percent of propylene glycol, 0.3 to 1.0 percent of benzalkonium chloride, 0.5 to 2.0 percent of glycerin, 0.5 to 2 percent of citric acid, 0.5 to 2 percent of polyethylene glycol 400, 0.3 to 1.0 percent of benzalkonium bromide, 0.1 to 0.5 percent of ethylparaben, 0.1 to 0.5 percent of methylparaben and the balance of purified water. The preparation method comprises the following steps of: spraying the chitosan and the carbomer on the liquid surface of the purified water, standing for a whole night to form a gel substrate, and removing bubbles under vacuum after standing; and then uniformly mixing the triethanolamine, the ethanol, the propylene glycol, the benzalkonium chloride, the glycerin, the citric acid, the polyethylene glycol, the benzalkonium bromide and the ethylparaben, and gradually adding into the gel substrate for uniformly mixing to prepare the chitosan contraceptive gel. The contraceptive gel is used in the vagina of a woman, has the effects of contraception, antibacterium and lubrication, avoids the influences on the vaginal pH, and maintains the normal balance of vaginal microflora; and the contraceptive gel also has the advantages of the antibacterium, inflection prevention, no damage to a genital mucosa, small irritation, low allergy and the like.

Description

technical field [0001] The invention relates to a contraceptive gel and a preparation method thereof, in particular to a chitosan contraceptive gel and a preparation method thereof, and belongs to the technical field of medicines. Background technique [0002] In the 1990s, after years of research, researchers invented a new type of contraceptive drug, which is called "liquid condom" or "invisible condom". Contraceptive release gel, referred to as "contraceptive gel", the surface of this gel is not much different from contraceptive jelly, the appearance is semi-liquid, slightly thicker than jelly, the placement method is similar, but the contraceptive gel The inert matrix differs from jelly in that the inert matrix is ​​a gel, not a jelly. Gel is a new type of biomimetic technology preparation. When it is placed in the vagina, it will immediately disperse in the vagina and adhere closely to the vaginal mucosa to form a protective film, which will gradually degrade and be di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/36A61P15/18
Inventor 林一文唐秉华
Owner 林一文
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