Biodegradable antibacterial contraception gel capable of realizing quantitative administration

Abstract

The invention relates to a commonly used drug spermicide for contraception, in particular to biodegradable contraception gel with antibacterial effect, and belongs to an autonomous external contraceptive. On the basis of the biodegradable contraception gel, exact quantitative administration can be realized by virtue of a disposable long cylinder applicator. The antibacterial contraception gel is composed of a spermicide, biodegradable gel and water. The gel is specifically vaginal gel compounded by silk fibroin and chitosan and comprises the following components in mass concentration: 2-8% ofsilk fibroin, 0.5-2% of chitosan, 0.5-2% of carbomer 940 or hydroxypropyl methyl cellulose, 5-12% of glycerol and propylene glycol and the balance of water, and pH value is regulated to be 3.5-5. Theproduct can achieve the effects of rapidly killing sperms and carrying out contraception and birth control, also has antibacterial effect and can prevent and alleviate germ infection in genital tract.Ingredients of the gel are biodegradable, and degradation products can be absorbed and have the effect of alleviating vaginal dryness and atrophy to some extent. The gel preparation fills a needle tube type tool and can be directly injected deep inside a vagina, and the aim of the exact quantitative administration is achieved. The product has good biocompatibility, can not influence pH of the vagina, has no side effect and is worthy of being popularized and applied in clinic.

Description

technical field [0001] The invention relates to the improvement of the preparation and administration of a novel contraceptive gel preparation. On the basis of self-administered contraception, it has the effect of antibacterial and improving some vaginal microenvironments. Background technique [0002] With the improvement of people's living standards and the change of ideas, in addition to some married couples who have undergone upper-stage birth control operations, many unmarried or married young people often use three types of rubber condoms, oral contraceptives, and external contraceptives. As the most commonly used contraceptive tool at present, the use of condoms also has safety problems such as partial allergic reactions, rupture and slippage during sexual intercourse, and there is a certain degree of discomfort. The disadvantage of oral contraceptives is the first-pass effect of the liver, which can cause adverse side effects such as nausea, vomiting, and even vagin...

AI Technical Summary

Problems solved by technology

As a contraceptive tool that is widely used at present, the use of condoms also has safety problems such as partial allergic reactions, rupture and slippage during sexual intercourse, and there is a certain degree of discomfort

The disadvantage of oral contraceptives is the first-pass effect of the liver, which can cause adverse side effects such as nausea, vomiting, and even vaginal bleeding in women

The existing treatment methods are mainly bactericides and antibiotics, bactericides often have local irritation, and the shortage of antibiotics is likely to cause bacterial resistance, drug resistance and side effects after use by the human body