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Method for preparing active biomimetic material for restoring stomach mucosa

A technology of biomimetic materials and mucous membranes, which is applied in the field of preparation of active biomimetic materials, can solve the problems of low drug efficacy, unknown main active ingredients, backward extraction methods, etc., and achieve the effect of convenient use and excellent biocompatibility

Inactive Publication Date: 2008-02-06
王剑峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The health care mechanism of synthetic chemical drugs is difficult to take into account the compatibility of human organs, which can easily lead to the situation of "removing the east wall and filling the west wall" in human organs; and most of the natural plant extracts (that is, Chinese herbal medicine) The main active ingredient is unknown, and the extraction method is outdated, resulting in low efficacy and difficulty entering the international market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention prepares the method for the active bionic material of repairing gastric mucosa to carry out according to the following steps:

[0019] (1) The chitosan raw material is crushed into particles of 80-100 mesh size with high-density crushing equipment;

[0020] (2) Pour the product obtained in step (1) into a NaOH alkaline solution with a concentration of 5% to 65%, and stir evenly at a speed of 1500 to 15,000 revolutions per hour: heat to 120°C within 30 minutes after the start of stirring ;Control the temperature to 120°C, and continue to stir for 1 hour; stop heating, and continue to stir until the temperature drops to 5-15°C;

[0021] (3) Repeat the stirring procedure described in step (2) 2 times;

[0022] (4) filter the product obtained in step (3), wash and dry with neutral deionized water, to obtain a modified chitosan with a molecular weight of more than 1,500,000 and a degree of deacetylation higher than 98%;

[0023] (5) Compounding the mo...

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Abstract

The invention discloses a preparation method of an active bionic material for repairing gastric mucosa. The chitosan material is firstly crushed into particles of 80-100 meshes by a high-density crushing device, and then added into an alkaline solution with the concentration of 5 percent-65 percent, stirred evenly and treated with base. Then the product is filtered, rinsed with neutral deionized water and dried, and the modified chitosan with molecular weight over 1.5 million and deacetylation degree more than 98 percent. The modified chitosan is compounded with other components to prepare the active bionic material for repairing gastric mucosa with chitosan content of 1 percent-100 percent. The active bionic material has definite chemical structure and efficacy mechanism, good biocompatibility with human body, non-exclusiveness and non-side effect, both short and long term efficacy.

Description

technical field [0001] The invention relates to a preparation method of an active bionic material for repairing gastric mucosa. Background technique [0002] The damage and pathology of human gastric mucosa will directly bring great pain to the human body and cause great inconvenience to work and life. Clinical manifestations: lesions characterized by varying degrees of erosion, shallow ulcers, and hemorrhage. The traditional methods of replenishing blood volume, hemostasis, and inhibiting gastric acid secretion often have no substantial effect on the repair of the gastric mucosa, resulting in a relatively long healing time for the gastric mucosa, relatively painful treatment, and the possibility of recurrence after temporary relief of pain larger. The current mainstream oral gastric health care or medical products for the treatment of gastric diseases mainly include synthetic chemical drugs and natural plant extracts. The health care mechanism of synthetic chemical drugs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20
Inventor 王剑峰
Owner 王剑峰