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Application of alpinia officinarum hance diarylheptanes compound in pain-alleviating and anti-inflammatory and its extracting method

A technology of galangal diphenylheptane and ginger diphenylheptane, which is applied in anti-inflammatory agents, drug combinations, drug delivery, etc.

Inactive Publication Date: 2008-02-20
GUANGDONG PHARMA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no report about the application of galanga diphenylheptane compounds in the treatment of analgesic drugs

Method used

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  • Application of alpinia officinarum hance diarylheptanes compound in pain-alleviating and anti-inflammatory and its extracting method
  • Application of alpinia officinarum hance diarylheptanes compound in pain-alleviating and anti-inflammatory and its extracting method
  • Application of alpinia officinarum hance diarylheptanes compound in pain-alleviating and anti-inflammatory and its extracting method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Get the rhizome of galangal, wash it, dry it, and crush it. Then put the dry powder into the supercritical fluid extraction tank and start supplying supercritical CO 2 , under the conditions of extraction pressure 28Mpa, extraction temperature 40°C, analysis pressure 6Mpa, analysis temperature 40°C and flow rate of 22L / hour for 4 hours, the reddish-brown oily substance was extracted.

[0047] Molecular distillation: The molecular distillation device is heated. When the temperature reaches 120°C. Turn on the vacuum pump to draw a vacuum. When the vacuum degree reaches 10Pa, add the supercritical extract from the feed port, adjust the rotating speed of the rotor scraping film to 270r / min, the flow rate to 1.8ml / min, and the cooling water temperature to 5°C. Two groups of fractions were collected respectively from the two outlets, and one group of fractions was galanga diphenylheptane compounds.

Embodiment 2

[0049] Get the rhizome of galangal, wash it, dry it, and crush it. Then put the dry powder into the supercritical fluid extraction tank and start supplying supercritical CO 2 , under the conditions of extraction pressure 30Mpa, extraction temperature 40°C, analysis pressure 6Mpa, analysis temperature 40°C, extraction is carried out at a flow rate of 22L / hour for 4 hours, and a reddish-brown oily substance is extracted.

[0050] Molecular distillation: The molecular distillation device is heated. When the temperature reaches 120°C, turn on the vacuum pump to draw a vacuum. When the vacuum reaches 10Pa, add the supercritical extract from the feed port, adjust the rotating speed of the rotor scraping film to 300r / min, the flow rate to 1.8ml / min, and the cooling water temperature to 3°C. Two groups of fractions were collected respectively from the two outlets, and one group of fractions was galanga diphenylheptane compounds.

Embodiment 3

[0052] Get the rhizome of galangal, wash it, dry it, and crush it. Then put the dry powder into the supercritical fluid extraction tank and start supplying supercritical CO 2 , under the conditions of extraction pressure 32Mpa, extraction temperature 40°C, analysis pressure 6Mpa, analysis temperature 40°C and flow rate of 22L / hour for 3.5 hours, a reddish-brown oily substance was extracted.

[0053] Molecular distillation: The molecular distillation device is heated. When the temperature reaches 150°C, turn on the vacuum pump to draw a vacuum. When the vacuum degree reaches 10Pa, add the supercritical extract from the feed port, adjust the rotating speed of the rotor scraping film to 250r / min, the flow rate to 1.8ml / min, and the cooling water temperature to 5°C. Two groups of fractions were collected respectively from the two outlets, and one group of fractions was galanga diphenylheptane compounds.

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Abstract

The present invention discloses an application of galangal diphenyl heptane compounds in analgesic and anti-inflammatory field and the extraction method. The present invention finds the new medical usage of the galangal diphenyl heptane compounds through the long-term studies and can be used in the preparation of the analgesic and anti-inflammatory drugs. The present invention adopts the supercritical carbon dioxide extraction method to extract the lipophilic effective active ingredients diphenyl heptane compounds from the galangal, the extraction efficiency is high, the present invention has no solvent residue toxicity, the natural active ingredients and the thermosensitive ingredients are not easy to be decomposed and damaged, so the natural characteristics of the natural extract can be maintained to the maximum extend. The present invention adopts the molecular distillation technology which is the most modest means for distillation and separation, thus overcoming the shortcomings of high temperature and long heating time in the traditional distillation operations, so the present invention is especially applicable to the separation of the materials with high boiling point and the thermosensitive materials.

Description

technical field [0001] The invention relates to galanga diphenylheptane compounds, in particular to the application of galanga diphenylheptane compounds in analgesic and anti-inflammation and an extraction method thereof. Background technique [0002] Since Vogel first reported the separation of curcumin from Curcuma Longa in 1815, a total of 67 natural linear diaryl heptane compounds have been discovered and established. This type of compound is mainly distributed in the rhizomes and stamens of plants of the genus Alpinia (Zingiberaceae), Curruma (Curruma) and Zingiber (Zingiber) and plants of the genus Alnus (Beturaceae) Among the bark and stamens, a few are also found in plants of the genus centrolobium in the family Leguminosae and plants of the genus Acer in the family Aceraceae. [0003] Linear diaryl heptane compounds mostly exist in ginger plants used as traditional medicine, spices, food and dyes in eastern countries (China, Japan, India). Pharmacological studies o...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K9/00A61K9/06A61K9/127A61K9/20A61K9/48A61P29/00
Inventor 冯毅凡石忠峰黄郁陈耕夫郭晓玲梁汉明
Owner GUANGDONG PHARMA UNIV
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