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Traditional Chinese medicine compound preparation for treating diabetes and nephrosis and preparing method thereof

A technology for diabetic nephropathy and compound preparations is applied in the field of traditional Chinese medicine compound preparations for treating diabetic nephropathy and its preparation, which can solve the problems of lack of treatment methods and prescriptions, and achieve the effects of reducing fasting blood sugar, protecting kidney function, and reducing urinary microalbumin.

Inactive Publication Date: 2008-04-30
中国人民解放军第八十五医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In short, there is no unified pathogenesis summary about diabetic nephropathy, and there is still a lack of effective treatment methods and prescriptions in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Rehmannia glutinosa, Salvia miltiorrhiza, and rhubarb were extracted three times with ethanol, each time for 1 to 2 hours. Raspberry and Epimedium are extracted by decocting together, that is, raspberry and Epimedium are soaked in water for 1 hour, added 8 to 10 times of water, extracted three times, and the water extract is concentrated to a relative density of 1.08 to 1.12 (80°C). Purification treatment is carried out, and the purification method adopts ethanol precipitation method, centrifugation method or chitosan clarification method. The above ethanol extracts of Rehmannia glutinosa, Salvia miltiorrhiza and Rhizoma rhubarb, and water-extracted and purified extracts of other medicinal flavors are combined and mixed. The weight ratio of each component is: Rehmannia glutinosa 26% Salvia miltiorrhiza 14% Epimedium 14% Rheum officinalis 14% Raspberry 14%, dry, adding appropriate auxiliary materials, made into solid oral dosage form.

[0036] The preparation method of ...

Embodiment 2

[0038] Rehmannia glutinosa, Salvia miltiorrhiza, and rhubarb were extracted three times with ethanol, each time for 1 to 2 hours. Raspberry and Epimedium are extracted by decocting together, that is, raspberry and Epimedium are soaked in water for 1 hour, added 8 to 10 times of water, extracted three times, and the water extract is concentrated to a relative density of 1.08 to 1.12 (80°C). Carry out purification treatment, and the purification method can be ethanol precipitation method, centrifugation method or chitosan clarification method. The above ethanol extracts of Rehmannia glutinosa, Salvia miltiorrhiza and Rhizoma rhubarb, and water-extracted and purified extracts of other medicinal flavors are combined and mixed. The weight ratio of each component is: Rehmannia glutinosa 26% Salvia miltiorrhiza 14% Epimedium 14% Rheum officinalis 23% Raspberry 23%, dry, adding appropriate auxiliary materials to make a solid oral dosage form.

[0039] The preparation method of the do...

Embodiment 3

[0041] Rehmannia glutinosa, Salvia miltiorrhiza, and rhubarb were extracted three times with ethanol, each time for 1 to 2 hours. Raspberry and Epimedium are extracted by decocting together, that is, raspberry and Epimedium are soaked in water for 1 hour, added 8 to 10 times of water, extracted three times, and the water extract is concentrated to a relative density of 1.08 to 1.12 (80°C). Carry out purification treatment, and the purification method can be ethanol precipitation method, centrifugation method or chitosan clarification method. The above-mentioned ethanol extracts of Rehmannia glutinosa, Salvia miltiorrhiza, and rhubarb, and other medicinal extracts extracted with water and purified, are combined and mixed, and the weight ratio of each component is: Rehmannia 38% Salvia 14% Epimedium 14% 14% rhubarb and 14% raspberry are dried and added with appropriate auxiliary materials to make a solid oral dosage form.

[0042]The preparation method of the dosage form can be...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine compound medicament for treating diabetic nephropathy and process for preparation, belonging to the traditional Chinese medicine field. The invention is prepared into various solid dosage forms which are suitable to oral administration and is made from the following traditional Chinese medicine, raw glutinous rehmannia, salvia miltiorrhizae, epimedium, prepared rhubarb, and raspberry and appropriate amount of excipient. The invention is showed through animal experiments that fasting plasma glucose of diabetic nephropathy model rat is significantly reduced, plasma glucagons is lowered, the contents of urinary albumin and urine beta 2 microglobulin are decreased, and the level of pituitary growth hormone is reduced. The invention has the effects of lowering hyperglycemia, reducing urinary albumin, and protecting kidney functions, which has important significance and applicable value for the treatment of diabetic nephropathy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound traditional Chinese medicine preparation for treating diabetic nephropathy and a preparation method thereof. Background technique [0002] Diabetic nephropathy is a common microvascular complication of diabetes and one of the leading causes of death in diabetes. It has an insidious onset and is usually asymptomatic in the early stages. Once it progresses to clinical proteinuria, edema, high blood pressure, and clinical diabetic nephropathy, the renal function damage will be irreversible and will eventually develop into end-stage renal failure. In recent years, more research work has been carried out on the prevention and treatment of diabetic nephropathy with traditional Chinese medicine, but there is a lack of systematic prospective research, especially in the early stage (urinary albumin excretion rate between 20 and 200 μg / min), the use of traditional Chin...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/16A61K9/20A61K9/46A61K9/48A61P3/10A61P13/12
Inventor 张景红郑士荣
Owner 中国人民解放军第八十五医院
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