Acidic biological adhesion heat-variable gelling agent, its preparing method and uses

A bioadhesive and sensitive gel technology, applied in diseases, drug combinations, drug delivery, etc., can solve problems such as the inability to prevent sperm from entering, the difficulty of GMP large-scale production, and poor bioadhesion
CN101172159AActive Publication Date: 2008-05-07上海市生物医药技术研究院
1 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海市生物医药技术研究院
Publication Date
2008-05-07

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses acidic biologic adhesion heat-variable gelling agent, which includes (a) 12-20 wt percent of polyoxy ethylene polyoxy propylene polymer, (b) 0.5-10wt percent of polydimethyl siloxane and (c) 1.0-2.5 wt percent of acidity buffering agent. The invention is characterized in that a pH value is 3.0 to 4.5, the gelling agent is under a liquid state at the temperature less than and equal to 28 DEG C, and is under a gel state at the temperature more than and equal to 32 DEG C. The acidic biologic adhesion heat-variable gelling agent is used to prepare liquid preparation with the function of both contraception and preventative spread disease (STDs / HIV). The acidic biologic adhesion heat-variable gelling agent provides reformation and convenience for a production process, the loading and filling operation of the liquid medicine is convenient, the filling amount is accurate, and the invention particularly is suitable for GMP scale production and becomes an optimal substitute of a contraceptive sheath or lubricating additive.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of pharmacy, in particular to a pharmaceutical excipient gel and its preparation method and application. Background technique

[0002] Gels have been used clinically for several years. At first, they were mostly prepared in small quantities for hospital preparations. Due to the continuous expansion of the application range and the continuous improvement of industrial production levels in recent years, more varieties of gels have been mass-produced. The requirement for commercially available gels is to keep the gel shape at room temperature without drying or liquefying.

[0003] For example, there is a gel on the market to control vaginal pH, Aci-Jel TM (Ortho-McNeil Pharmaceutical Corp., Raitan, NJ), which is a water-dispersible buffered gel with a pH of 3.9-4.1, is used to restore and maintain normal vaginal acidity. It becomes a gel no matter in the normal temperature outside the body or in the temperature environ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More