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Application of motherwort aqueous extract in the preparation of medicament for curing ischemic heart disease

A technology of ischemic heart disease and water extract, applied in the direction of drug combination, cardiovascular system disease, pharmaceutical formulation, etc.

Inactive Publication Date: 2008-05-14
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the treatment of ischemic heart disease

Method used

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  • Application of motherwort aqueous extract in the preparation of medicament for curing ischemic heart disease
  • Application of motherwort aqueous extract in the preparation of medicament for curing ischemic heart disease
  • Application of motherwort aqueous extract in the preparation of medicament for curing ischemic heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Motherwort water decoction is filtered and concentrated, and then checked by high-performance liquid chromatography-mass spectrometry, using photodiode array detector (DAD) and electrospray (ESI) mass spectrometry, which contains stachydrine (Stachydrine), mountain Naphthalene (Kaempferol) and quercetin (quercetin) and other main components.

Embodiment 2

[0025] Take motherwort water extract, add appropriate amount of microcrystalline cellulose, starch or other excipients, and make capsules, tablets, powders, granules, pills and other oral dosage forms according to conventional methods.

Embodiment 3

[0026] Example 3 In vivo test of HL's effect of inhibiting apoptosis and promoting capillary neogenesis

[0027] In vivo assays to detect the expression of apoptosis genes and VEGF genes: semi-quantitative analysis of the mRNA levels of p53(A), Fas(B), Bcl-xl(C), Bcl-xs(D) and VEGF(E) by conventional methods , using the gene expression of GAPDH as an internal reference, the results showed that: the apoptosis gene P in the HL myocardial infarction treatment group 53 The expressions of Fas and Fas were significantly lower than those of the control group treated with water myocardial infarction, Pfigure 1 ). The results showed that conditions such as tissue damage or hypoxia can induce a sudden increase in VEGF gene expression, triggering angiogenesis to meet the increased demand for oxygen supply. The gene expression of VEGF in the HL myocardial infarction treatment group was significantly higher than that in the control group (P<0.05), indicating that the former had higher ang...

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Abstract

The invention relates to an application of the Chinese herbal medicine leonurus japonicus aqueous extract in the preparation of the drug composition, in particular to the application in the preparation of the drug treating the ischemic heart disease through promoting the growth of the newborn blood vessel, which belongs to the Chinese herbal medicine pharmacy field. Proved by the result of the in vitro experiment and the in vivo animal experiment, the leonurus japonicus aqueous extract has the advantages of higher blood vessel newborn activeness, capability of promoting the growth of the newborn blood vessel, in particular to the coronary capillary, and capability of satisfying the oxygen supplying demand of the ischemic myocardial. The leonurus japonicus active component can be used as the drug material, made into the proper preparation directly or mixed with the solid or liquid commonly used for the preparation in the pharmacy, comprising the capsule, the tablet, the powder and the compound preparation.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the application of water extract of motherwort, a Chinese herbal medicine, in the preparation of pharmaceutical compositions, especially the application in the preparation of medicines for treating ischemic heart disease by promoting the growth of new blood vessels. Background technique [0002] Ischemic cardiomyopathy is the leading cause of death in both developed and developing countries in recent decades. Reducing morbidity and mortality from such diseases is important. The endogenous antioxidant system of the heart includes superoxide dismutase (superoxide dismutase, SOD), catalase (catalase, CAT), glutathione peroxidase (glutathioneperoxidase, GPx) and other antioxidants. The increase of reactive oxygen species (Reactive oxygen species, ROS) in the body exceeds the scavenging capacity of the endogenous antioxidant system, leading to oxidative stress, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61P9/10A61K31/352A61K31/40
Inventor 朱依谆朱依纯
Owner FUDAN UNIV
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