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Medicinal box of GSA for producing technetium-99m mark and method for producing the same

A 99mtc-gsa and kit technology, applied in the direction of radioactive carriers, can solve the problems of lack of ASGPR imaging agent, lack of ASGPR imaging agent freeze-drying matching kit, etc., achieve high labeling rate, harsh preparation conditions, high Effect of target/non-target ratio

Active Publication Date: 2008-07-16
容成医学技术无锡有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This research is still blank in our country, mainly due to the lack of ASGPR imaging agents for nuclear medicine imaging, especially the lack of freeze-dried kits for ASGPR imaging agents that can be used clinically, are easy to use, and are easy to promote.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of 75 GSA freeze-dried kits

[0043] 1) Dissolve 225mg GSA ligand in 37.5mL pH3.5 sodium acetate-acetate buffer, then add 0.4mL 3.8mg / mL SnCl 2 2H 2 O hydrochloric acid solution (1mol / L); the solution is mixed evenly, and its pH is controlled between 3.0 and 3.5;

[0044] 2) Add 75 mg of potassium sodium tartrate to the solution obtained in step 1), and then dilute to 75 mL with nitrogen-filled secondary water;

[0045] 3) After the solution prepared in step 2) is aseptically filtered, it is divided into 75 control antibiotic bottles, and then placed in a freeze dryer for 24 hours, and then sealed with a stopper to obtain the preparation method according to the present invention. 99m Freeze-dried kit of Tc-GSA.

Embodiment 2

[0047] Preparation of 100 GSA freeze-dried kits

[0048] 1) Dissolve 200mg of GSA ligand in 50mL pH3.5 sodium acetate-acetate buffer, then add 1mL of 10mg / mL SnCl 2 2H 2 O hydrochloric acid solution (1mol / L); the solution is mixed evenly, and its pH is controlled between 2.5 and 3.0;

[0049] 2) Add potassium sodium tartrate 200 mg to the solution obtained in step 1), and then dilute to 100 mL with nitrogen-filled secondary water;

[0050] 3) After the solution prepared in step 2) is aseptically filtered, it is divided into 100 control antibiotic bottles, and then placed in a freeze dryer for 24 hours, and then sealed with a stopper, to obtain the preparation method according to the present invention. 99m Freeze-dried kit of Tc-GSA.

Embodiment 3

[0052] Preparation of 75 GSA freeze-dried kits

[0053] 1) Dissolve 600mg GSA ligand in 37.5mL pH3.5 sodium acetate-acetate buffer, then add 0.2mL 3.8mg / mL SnCl 2 2H 2 O hydrochloric acid solution (1mol / L); the solution is mixed evenly, and its pH is controlled between 3.5~4.0;

[0054] 2) Add 3.75 mg of potassium sodium tartrate to the solution obtained in step 1), and then dilute to 75 mL with nitrogen-filled secondary water;

[0055] 3) After the solution prepared in step 2) is aseptically filtered, it is divided into 75 control antibiotic bottles, and then placed in a freeze dryer for 24 hours, and then sealed with a stopper to obtain the preparation method according to the present invention. 99m Freeze-dried kit of Tc-GSA.

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Abstract

The invention relates to a kit which is used for preparing <99M> Tc-GSA. Weight ratio of a reducing agent of the kit: a GSA ligand: adjuvant is 0.01-0.2:2-8:0.05-2; the reducing agent is a routine chemical reagent which can reduce <99M> Tc <7+> (<99M> TcO4<->) to <99M> Tc <5+>. The invention also relates to a preparation method of the kit. In the preparation of <99M> Tc-GSA, the kit of the invention has the advantages of simple method, high mark rate, excellent biological properties of prepared <99M> Tc-GSA and low use cost, and facilitates wide clinical application.

Description

technical field [0001] The invention relates to a method for preparing technetium-99m ( 99m The supporting lyophilized kit of GSA of Tc), and the preparation method of the kit. Background technique [0002] Plasma asialoglycoprotein receptor (ASGP-R) exists on the membrane of mammalian liver cells, which mediates the specific site for the liver to clear asialoglycoprotein (ASGP) from blood. ASGP-R can reflect effective liver cell function to a certain extent. When liver injury diseases such as hepatitis, cirrhosis or liver cancer occur, its quantity and activity are damaged. Therefore, quantitative analysis of ASGP-R is helpful in Better judge the function of the remaining liver before surgery. Among the many means of evaluating liver function, liver imaging methods are developing rapidly. In particular, nuclear medicine uses single photon emission computer tomography (SPECT) to monitor the uptake, metabolism, excretion and other functions of liver cells. The dynamic obse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/08A61K103/10
Inventor 张现忠杨文江王学斌唐志刚
Owner 容成医学技术无锡有限公司
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