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Active component composition used as adjuvant drug for antitumor and preparation and application thereof

A technology of effective parts and adjuvant medication, which is applied in the direction of antineoplastic drugs, drug combinations, medical preparations containing active ingredients, etc., and can solve problems such as unretrieved

Inactive Publication Date: 2008-08-13
酒泉大得利制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After searching relevant information, it was not found that the effective fractions of astragalus and angelica polysaccharides were optimally combined to form an effective fraction group, which was produced and processed into suitable pharmaceutical preparations for adjuvant medicine in the treatment of tumor diseases

Method used

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  • Active component composition used as adjuvant drug for antitumor and preparation and application thereof

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Experimental program
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preparation example Construction

[0114] Preparation of Astragalus Polysaccharide: Take 2Kg of Radix Astragali, extract twice at 70°C with 10 times the amount of water, for 2 hours each time. Collect the extract, concentrate it to about 1L, place it at room temperature, centrifuge, add pre-cooled ethanol to the supernatant to make the alcohol content reach 65%, let it stand at 4°C for 24 hours, and take the precipitated astragalus crude polysaccharide. Dissolve Astragalus crude polysaccharide in 500 mL of water, add an equal volume of 5% trichloroacetic acid, shake at 5°C for 10 minutes, stand at 5°C for 1 hour, centrifuge to remove precipitate, and treat in the same way 3 times to remove protein. Adjust the pH value of the polysaccharide solution after protein removal to 7.0 with NaOH, centrifuge, add pre-cooled ethanol to the supernatant to make the alcohol content reach 75%, let it stand at 4°C for 24 hours, and take the precipitated astragalus polysaccharide. Astragalus polysaccharide was dissolved in 25L ...

Embodiment 2

[0117] Example 2 Take 2 g of astragalus polysaccharide, 10 g of angelica polysaccharide, and 40 g of polyethylene, mix them uniformly, granulate, compress into tablets, and dry to prepare a pharmaceutical composition in the form of slow-release tablets containing 1 part of astragalus polysaccharide and 5 parts of angelica polysaccharide .

Embodiment 3

[0118] Example 3 Take 10 g of astragalus polysaccharide, 10 g of angelica polysaccharide, and 80 g of sucrose, mix them uniformly, granulate, sieve, and dry to prepare a pharmaceutical composition in the form of granules containing 1 part of astragalus polysaccharide and 1 part of angelica polysaccharide; or The prepared granules are further pressed into tablets and dried to obtain a pharmaceutical composition in the form of tablets containing 1 part of astragalus polysaccharide and 1 part of angelica polysaccharide.

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Abstract

Disclosed is an active component composition as an assistant drug for tumor, wherein an actual total content of astragalus polysaccharide and angelica polysaccharide which are active components reaches above 50% of total extracts. The active component capable of forming a suitable formulation with an appropriate physiologically acceptable excipient, can enhance the immune function and the disease-resistant ability, and also works as raw material for producing adjuvant treatment drug and rehab treatment drug after radiotherapy, chemotherapy and surgical treatment for tumor.

Description

technical field [0001] The invention belongs to the field of research and development of traditional Chinese medicines, and relates to an effective part composition used as an adjuvant drug for tumors, in particular to an effective part group composed of effective parts extracted from Chinese medicinal materials Astragalus and Angelica sinensis and preparations thereof, and the preparation of effective parts for tumor diseases Application in adjuvant therapy drugs and rehabilitation therapy drugs after radiotherapy, chemotherapy, and surgical treatment. Background technique [0002] Malignant tumors are currently one of the major diseases that seriously threaten human life and health. According to statistics from the World Health Organization, 10 million cancers occur each year in the world and 7 million die. It is the second largest killer of human beings after cardiovascular diseases. In recent years Due to the acceleration of population aging, aggravated environmental pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K31/715A61K9/00A61P35/00
Inventor 张铁军龚苏晓许会生
Owner 酒泉大得利制药股份有限公司
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