Anticancer sustained-release gel injection and preparation method thereof

Abstract

A sustained-release gel injection comprises angiogenesis inhibitor and / or carmustine or nimustine, amphiphilic block copolymer and solvent, wherein the angiogenesis inhibitor is selected from SU5416, SU6668, alemtuzumab, axitinib, ibritumomab, bevacizumab, sutent, dasatinib, tarceva, vandetanib, gefitinib, lapatinib, lapatinib, sunitinib, sorafenib, endostatain, engiostatin, tositumomab, tipifarnib, sirolimus, cetuximab, ematinib, lenalidomide and thalidomide. The mixture of amphiphilic block copolymer and solvent has temperature sensitive gelatinization characteristic, is fluid liquid at room temperature, and automatically becomes non-flowing biodegradable water insoluble gel in warm-blooded animals. The preparation can locally slowly release at tumor foci and maintain effective drug concentration for several weeks to several months; and has effects on killing tumor cells, effectively inhibiting tumor angiogenesis, reducing systemic toxicity of drug, and enhancing the treatment effect of chemotherapy and radiotherapy (particularly radioactive particles).

Description

A kind of anticancer sustained-release gel injection and preparation method thereof A kind of anticancer sustained-release gel injection and preparation method thereof (1) Technical field The invention relates to an anti-cancer sustained-release gel injection and a preparation method thereof, belonging to the technical field of medicines. Specifically, the invention relates to a slow-release gel preparation capable of stably releasing neovascularization inhibitors and / or statins locally in solid tumors, mainly slow-release gel injections. It is an aqueous solution at room temperature and can become a semi-solid or solid gel in warm-blooded animals. (2) Background technology Cancer has become the number one killer of human health. Although there are many ways to treat cancer, the living conditions of most patients have not been significantly improved. Among the various treatments, chemotherapy remains one of the commonly used options. Although conventional chemotherapy...

AI Technical Summary

Problems solved by technology

Therefore, in most cases, the final sustained-release formulations are mostly solid shapes (eg, microspheres, tablets, or rods), which require a more complicated implantation process, and are prone to tissue trauma and even tumor cell seeding or dissemination

In addition, organic solvents or high-heat processes often lead to the degradation and denaturation of many anti-cancer active ingredients, and solid implants cannot effectively cover the irregular tumor cavity after tumor resection, so residual tumor cells cannot be effectively removed after surgery.