Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof

A traditional Chinese medicine preparation, a technology for the aged, applied in the direction of pharmaceutical formulations, medical raw materials derived from mollusks, and medical preparations containing active ingredients, etc.

Inactive Publication Date: 2010-09-08
浙江省中药研究所有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs for the treatment of dementia at home and abroad mainly include cholinesterase inhibitors, pro-metabolism drugs, non-steroidal anti-inflammatory drugs, antioxidants, neurovascular regulators, estrogen therapy, etc. The above drugs have certain curative effects on early and mid-stage AD , mainly for symptomatic treatment, the overall effect is not ideal, and has varying degrees of toxic and side effects, some even have heart, liver, and kidney toxicity, making it difficult for patients to accept long-term treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1) Take 900g of fresh purple mussels, shell them, wash the shellfish, homogenate, add water and mix evenly, filter, discard the filter residue, after the filtrate is homogenized in a homogenizer, spray dry to obtain purple mussel powder, set aside, The homogenization condition of the homogenizer is low pressure 10Kg / cm 2 , High pressure 35Kg / cm 2 , the nozzle speed in the spray drying is 16000 rpm, the inlet air temperature is 170°C, and the outlet air temperature is 80°C;

[0019] 2) Take 270g of Rhizoma Chuanxiong, 180g of Ginkgo, 270g of Yizhiren, 270g of Shichangpu, 180g of Schisandra chinensis, and 450g of Baiziren, grind them, put them in a supercritical extractor and extract them with carbon dioxide as a fluid for 4 hours. The extraction conditions are extraction pressure 11Mpa, extraction temperature 37°C, carbon dioxide flow rate 30Kg / hr;

[0020] 3) Take 450g of Astragalus membranaceus, 180g of Eucommia ulmoides, 180g of Polygala three flavors, add 8 to 12 t...

Embodiment 2

[0023] 1) Take 1100g of fresh purple mussels, shell them, wash the shellfish, homogenate, add water and mix evenly, filter, discard the filter residue, after the filtrate is homogenized in a homogenizer, spray dry to obtain purple mussel powder, set aside, The homogenization condition of the homogenizer is low pressure 18Kg / cm 2 , High pressure 50Kg / cm 2 , the nozzle speed in spray drying is 20,000 rpm, the inlet air temperature is 200°C, and the outlet air temperature is 100°C;

[0024] 2) Take 330g of Rhizoma Chuanxiong, 220g of Ginkgo, 330g of Yizhiren, 330g of Shichangpu, 220g of Schisandra chinensis, and 550g of Baiziren, grind them, put them in a supercritical extractor and extract them with carbon dioxide as a fluid for 6 hours. The extraction conditions are extraction pressure 14Mpa, extraction temperature 40°C, carbon dioxide flow rate 45Kg / hr;

[0025] 3) Take 550g of Astragalus membranaceus, 220g of Eucommia ulmoides, 220g of Polygala three flavors, add 12 times o...

Embodiment 3

[0028] 1) Take 1000g of fresh purple mussels, shell them, wash the shellfish, homogenate, add water and mix evenly, filter, discard the filter residue, after the filtrate is homogenized in a homogenizer, spray dry to obtain purple mussel powder, set aside, The homogenization condition of the homogenizer is low pressure 12Kg / cm 2 , High pressure 40Kg / cm 2 , the nozzle speed in spray drying is 19,000 rpm, the inlet air temperature is 195°C, and the outlet air temperature is 95°C;

[0029] 2) Take 300g of Rhizoma Chuanxiong, 200g of Ginkgo, 300g of Yizhiren, 300g of Shichangpu, 200g of Schisandra chinensis, and 500g of Baiziren, crush them, put them in a supercritical extractor and extract them with carbon dioxide as a fluid for 5 hours, and the extracts will be used for later use in a supercritical extractor The extraction conditions are extraction pressure 12Mpa, extraction temperature 38°C, carbon dioxide flow rate 35Kg / hr;

[0030] 3) Take 500g of Astragalus membranaceus, 2...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a traditional Chinese medicinal preparation for curing senile dementia and a preparation method thereof. The traditional Chinese medicinal preparation consists of the following raw herbal materials: 4.5 to 5.5g of radix astragali, 2.7 to 3.3g of hemlock parsley, 1.8 to 2.2g of ginkgo, 2.7 to 3.3g of fructus zingiberis nigri, 2.7 to 3.3g of grassleaved sweetflag, 1.8 to 2.2g of schizandra sinensis, 4.5 to 5.5g of Chinese arborvitae seed, 1.8 to 2.2g of eucommia, 1.8 to 2.2g of milkwort and 9 to 11g of common mussel. The preparation method includes the following steps: (1) the fresh common mussel is cleaned, homogenized and filtered, thus obtaining homogenized filtrate which is subject to spray drying to obtain the common mussel powder; (2) six medicinal materials such as hemlock parsley and ginkgo, and the like, are ground and extracted by supercritical extraction technique; (3) three medicinal materials such as radix astragali, and the like, are decocted with water, then the water extract is combined, filtered, concentrated, deposited with alcohol, frozen, filtered and concentrated, and spray-dried to obtain extract powder; (4) the common mussel powder and the extract powder are mixed, added with the extract and the auxiliary materials, ground, taken as the filler and prepared into soft capsules. The present invention has the efficacies of enriching qi, promoting blood circulation and removing obstruction in collaterals, nourishing the kidney and the heart, and refreshing brain, which can prevent and cure senile dementia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating senile dementia and a preparation method thereof. Background technique [0002] Entering the 21st century, the whole world is entering the age of aging, and senile dementia has become the fourth disease after cardiovascular and cerebrovascular diseases and tumors. Data show that the speed of population aging in my country is extremely rapid. At present, the number of elderly people over 60 years old in my country has reached 120 million. [0003] Senile dementia is a common degenerative disease of the central nervous system, including Alzheimer's dementia, vascular dementia, mixed dementia and other dementias. Among them, the former two are the two main types of senile dementia, accounting for more than 90% of all senile dementia patients. Alzheimer's disease (AD), also known as senile dementia, is a dementia syndrome based on primary brain degeneration and atrophy of br...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61P25/28A61K35/56A61K35/618
Inventor 王溶溶杨苏蓓杨明华陈丹菲章曙丹汤建成
Owner 浙江省中药研究所有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products