Antineoplastic composition and use thereof

A composition and anti-tumor technology, which can be used in anti-tumor drugs, drug combinations, active ingredients of heavy metal compounds, etc., can solve the problems of reduced topoisomerase activity, reduced tumor efficacy of platinum drugs, and reduced drug potency.
CN101332301AInactive Publication Date: 2008-12-31NANJING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING MEDICAL UNIV
Publication Date
2008-12-31
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses an anti-tumor combination and the application thereof; the anti-tumor combination which includes effective dose of platinum-based chemotherapy and AKT inhibitor and / or p70S6K1 inhibitor has the function of inhibiting the drug resistance of the tumor to the platinum-based chemotherapy, improves the effects of anti-tumor drugs, and can be used for preparing drugs that can resist various tumors, such as lung cancer, ovarian cancer, prostate cancer, breast cancer, stomach cancer, nasopharyngeal cancer, esophageal cancer, malignant lymphoma, head and neck squamous cell carcinoma, thyroid cancer, osteosarcoma, etc.
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Description

technical field

[0001] The invention belongs to the field of pharmacy, and relates to an antitumor composition and its application. Background technique

[0002] Since Rosenberg et al. [1] discovered that platinum group compounds have anticancer activity in 1965, the research and application of platinum group metal anticancer drugs have developed rapidly. Cisplatin (cisplatin, cis-dichlorodiammine platinum, Cisplatin, Cis-Diaminodichloroplatin Platinol, CDDP) is one of the most effective. CDDP has the characteristics of broad anti-cancer spectrum, strong effect, and synergistic effect with various anti-tumor drugs. It is one of the most commonly used drugs in current combination chemotherapy. Esophageal cancer, malignant lymphoma, breast cancer, head and neck squamous cell carcinoma, thyroid cancer and osteosarcoma and other solid tumors can show curative effect. [2]. According to statistics, in my country, CDDP-based or compatible chemotherapy regimens with CDDP account ...

Claims

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