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Medicine composition containing 15 kinds of amino acid and preparation method thereof

An amino acid and composition technology, applied in the field of medicine, can solve problems such as huge investment, achieve the effects of saving transformation investment, eliminating process loopholes, and solving oxidation problems

Active Publication Date: 2009-02-04
郑飞雄
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] It is worth pointing out that the vast majority of compound amino acid injection manufacturers in my country do not yet have the technological conditions and equipment for the whole production process of nitrogen protection. There are still uncertainties in achieving the goal

Method used

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  • Medicine composition containing 15 kinds of amino acid and preparation method thereof
  • Medicine composition containing 15 kinds of amino acid and preparation method thereof
  • Medicine composition containing 15 kinds of amino acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] 1. Prescription:

[0068] L-Isoleucine 7.66g L-Leucine 13.75g L-Lysine Acetate 5.8g L-Methionine 2.5g

[0069] L-Phenylalanine 3.2g L-Threonine 2.0g L-Tryptophan 0.9g L-Valine 8.86g

[0070] L-Alanine 4.0g L-Arginine 5.8g L-Histidine 1.6g L-Proline 6.3g

[0071] L-serine 3.3g Glycine 3.3g L-cysteine ​​hydrochloride 0.1g

[0072] Citric acid 0.3g Water for injection Appropriate amount Full amount 1000ml

[0073] 2. Preparation process

[0074] Weigh each raw material according to the prescription.

[0075] Add 800ml of hot water for injection into the three-necked bottle, fill it with nitrogen for 30 minutes, keep the temperature at 90±2°C, add citric acid under the protection of nitrogen filling, stir and dissolve;

[0076] Under nitrogen protection, the L-proline, L-serine, L-alanine, L-isoleucine, L-leucine, glycine, L-phenylalanine, Put L-methionine, L-threonine, L-lysine acetate, L-valine, L-arginine and L-histidine into the citric acid solution, stir evenly t...

Embodiment 2

[0080] 1. Prescription:

[0081] L-Isoleucine 77g L-Leucine 138g L-Lysine Acetate 58g L-Methionine 25g

[0082] L-Phenylalanine 32g L-Threonine 20g L-Tryptophan 9g L-Valine 89g

[0083] L-alanine 40g L-arginine 58g L-histidine 16g L-proline 63g

[0084] L-serine 33g Glycine 33g L-cysteine ​​hydrochloride 1g

[0085] Citric acid 2.6g Water for injection Appropriate amount Full amount 10000ml

[0086] 2. Preparation process

[0087] Weigh each raw material according to the prescription.

[0088] Add 8000ml of water for injection into the preparation tank, heat it, fill it with nitrogen for 30 minutes, keep the temperature at 90±1°C, add citric acid under the protection of nitrogen filling, stir and dissolve;

[0089]Under nitrogen protection, the above weighed L-proline, L-serine, L-alanine, L-isoleucine, L-leucine, glycine, L-phenylalanine, L - Put methionine, L-threonine, L-lysine acetate, L-valine, L-arginine and L-histidine into the citric acid solution, stir evenly to...

Embodiment 3

[0093] 1. Prescription:

[0094] L-Isoleucine 62g L-Leucine 88g L-Lysine Acetate 46g L-Methionine 8g

[0095] L-Phenylalanine 8g L-Threonine 16g L-Tryptophan 5g L-Valine 69g

[0096] L-Alanine 33g L-Arginine 46g L-Histidine 12g L-Proline 50g

[0097] L-Serine 26g Glycine 28g L-Cysteine ​​Hydrochloride 2g

[0098] Citric acid 4g Water for injection Appropriate amount Full amount 10000ml

[0099] 2. Preparation process

[0100] Weigh each raw material according to the prescription.

[0101] Add 8000ml of water for injection into the preparation tank, heat it, fill it with nitrogen for 30 minutes, and keep the temperature at 90±3°C.

[0102] Add citric acid under nitrogen protection, stir and dissolve;

[0103] Under nitrogen protection, the above weighed L-proline, L-serine, L-alanine, L-isoleucine, L-leucine, glycine, L-phenylalanine, L - Put methionine, L-threonine, L-lysine acetate, L-valine, L-arginine and L-histidine into the citric acid solution, stir evenly to diss...

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Abstract

The invention discloses a medicine combination which contains 15 amino acids and the preparation method thereof; the medicine combination is characterized in that a compound amino acid injecta with different concentrations are prepared by the 15 amino acids which serve as raw materials and admixture according to the following parts by weight: 6.1-10.8 parts of L-Isoleucine, 8.8-16.6 parts of L-Leucine, 4.6-10.4 parts of L-Lysine Acetate, 0.8-3.0 parts of L-Methionine, 0.8-3.9 parts of L-Phenylalanine, 1.6-5.4 parts of L-threonine, 0.5-1.1 parts of L-Tryptophan, 6.7-10.7 parts of L-Valine, 3.2-9.3 parts of L-alanine, 4.6-7.2 parts of L-arginine, 1.2-2.9 parts of L-Histidine, 5.0-9.6 parts of L-proline, 2.6-6.0 parts of L-serine, 2.6-10.8 parts of glycin, 0.1-1.0 parts of L-Cysteine hydrochloride, 0.1-0.5 parts of citric acid and moderate water for injection. The injecta does not contain sulphite type chemical inhibitor, thoroughly solves the harm of sulphite type on human body, and ensures that the obtained products are safer. The PH value of the injecta is 5.5-7.0. By the accelerated test and quality test, the results show that the stability of the medicine combination which contains 15 amino acids is the same as or better than like products which contains sulphite type sold on market.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to a pharmaceutical composition containing 15 kinds of amino acids and a preparation method thereof. Background technique [0002] The pharmaceutical composition containing 15 kinds of amino acids is a sterilized aqueous solution prepared from 15 kinds of amino acids plus auxiliary materials, and is clinically used for parenteral nutrition. [0003] Since amino acids are very unstable in solution, they are easily oxidized to produce a series of complex substances harmful to the human body. Since the compound amino acid injection was put into production and use in the 1960s, in order to ensure the stability of the product, sulfite compounds with unique antioxidant properties, such as sodium bisulfite and sodium metabisulfite, must be added. Since people did not understand the harm of such substances to the human body at that time, manufacturers usually added them in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4172A61K31/198A61K31/401A61K31/405
Inventor 郑飞雄
Owner 郑飞雄
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