Pharmaceutical composition containing 18 kinds of amino acid

Abstract

The invention discloses a pharmaceutical composition containing 18 amino acids. The pharmaceutical composition is characterized in that a compound amino acid injection (18AA-II) with varied concentration is prepared by using the following components according to the following ratios of parts by weight: 1.50 of aspartic acid, 2.50 of glutamic acid, 1.90 of serine, 3.00 of histidine, 3.50 of glycine, 2.50 of threonine, 7.20 of alanine, 4.90 of arginine, 0.20 of tyrosine, 0.20 of cystine, 3.20 of valine, 2.50 of methionine, 0.85 of tryptophan, 3.50 of phenylalanine, 2.50 of isoleucine, 3.40 of leucine, 5.50 of lysine acetate, 2.90 of proline, 0.10 of cysteine hydrochloride and 0.20 of lemon acid. The composition does not contain a sulfite antioxidant so that the pharmaceutical composition isclinically used in a safer manner. After an accelerated test, a test result shows that the pharmaceutical composition containing 18 amino acids is as stable as or more stable than like products whichare sold in the markets and contain sulfites.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to a pharmaceutical composition containing 18 kinds of amino acids. Background technique [0002] The pharmaceutical composition containing 18 kinds of amino acids is a sterilized aqueous solution prepared from 18 kinds of amino acids plus auxiliary materials, and is clinically used for parenteral nutrition. [0003] Since amino acids are very unstable in solution, they are easily oxidized to produce a series of complex substances harmful to the human body. Since the compound amino acid injection was put into production and use in the 1960s, in order to ensure the stability of the product, sulfite compounds with unique antioxidant properties, such as sodium bisulfite and sodium metabisulfite, must be added. Since people did not understand the harm of such substances to the human body at that time, manufacturers usually added them in large quantities without restric...

AI Technical Summary

Problems solved by technology

It is worth pointing out that the vast majority of compound amino acid injection manufacturers in my country do not yet have the technological conditions and equipment for the whole production process of nitrogen protection. There are still uncertain factors to achieve the goal. It can be said that the solution is completely free of oxygen, which is impossible to achieve in actual production.

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