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Amino acid composition containing new antioxidant

An antioxidant and composition technology, applied in the field of medicine, can solve problems such as huge investment, achieve the effects of saving transformation investment, solving harm to human body, and eliminating process loopholes

Active Publication Date: 2013-01-30
郑飞雄
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is worth pointing out that the vast majority of manufacturers of compound amino acid injections in my country do not yet have the technological conditions and equipment for nitrogen protection throughout the production process. There are still uncertain factors whether to achieve the purpose. It can be said that the solution is completely free of oxygen and it is impossible to achieve in actual production.

Method used

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  • Amino acid composition containing new antioxidant
  • Amino acid composition containing new antioxidant
  • Amino acid composition containing new antioxidant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] 1. Prescription:

[0110] Isoleucine 9.10g Leucine 12.90g Lysine Acetate 10.00g

[0111] Methionine 4.40g Phenylalanine 7.00g Threonine 7.50g

[0112] Tryptophan 1.30g Valine 14.00g Alanine 7.10g

[0113] Arginine 9.00g Aspartic Acid 1.00g Glutamic Acid 0.50g

[0114] Histidine 5.00g Proline 5.00g Serine 1.70g

[0115] Tyrosine 0.40g Glycine 7.00g Cysteine ​​0.35g

[0116] Citric acid 0.1g water for injection appropriate amount

[0117] Full volume 1000ml

[0118] 2. Preparation process

[0119] (1) Weigh each raw material and auxiliary material according to the prescription;

[0120] (2) Take about 80% of the total amount of water for injection, heat it to above 95°C, keep it warm for more than 30 minutes with nitrogen, control the water temperature at 80-85°C, add citric acid under the protection of nitrogen flow, and dissolve;

[0121] (3) Under the protection of nitrogen flow, add inhalantic acid, tyrosine, leucine, phenylalanine, glutamic acid, isoleucine, ...

Embodiment 2

[0126] 1. Prescription:

[0127] Isoleucine 8.19g Leucine 11.61g Lysine Acetate 9.00g

[0128] Methionine 3.96g Phenylalanine 6.30g Threonine 6.75g

[0129] Tryptophan 1.17g Valine 12.60g Alanine 6.39g

[0130] Arginine 8.10g Aspartic acid 0.90g Glutamic acid 0.45g

[0131] Histidine 4.50g Proline 4.50g Serine 1.53g

[0132] Tyrosine 0.36g Glycine 6.30g Cysteine ​​0.32g

[0133] Citric acid 0.2g water for injection appropriate amount

[0134] The total volume is 1000ml.

[0135] 2. Preparation process

[0136] (1) Weigh each raw material and auxiliary material according to the prescription;

[0137] (2) Take about 80% of the total amount of water for injection, heat it to above 95°C, keep it warm for more than 30 minutes with nitrogen, control the water temperature at 80-85°C, add citric acid under the protection of nitrogen flow, and dissolve;

[0138] (3) Under the protection of nitrogen flow, add inhalantic acid, tyrosine, leucine, phenylalanine, glutamic acid, isol...

Embodiment 3

[0143] 1. Prescription:

[0144] Isoleucine 91.0g Leucine 129.0g Lysine Acetate 100.0g

[0145] Methionine 44.0g Phenylalanine 70.0g Threonine 75.0g

[0146] Tryptophan 13.0g Valine 140.0g Alanine 71.0g

[0147] Arginine 90.0g Aspartic acid 10.0g Glutamic acid 5.0g

[0148] Histidine 50.0g Proline 50.0g Serine 17.0g

[0149] Tyrosine 4.0g Glycine 70.0g Cysteine ​​3.5g

[0150] Citric acid 2.0g water for injection appropriate amount

[0151] Full volume 10000ml

[0152] 2. Preparation process

[0153] (1) Weigh each raw material and auxiliary material according to the prescription;

[0154] (2) Add 80% water for injection in the preparation tank, heat it, fill it with nitrogen for 30 minutes, keep the temperature above 85°C, add citric acid under the protection of nitrogen filling, stir and dissolve;

[0155] (3) Under the protection of nitrogen flow, add inhalantic acid, tyrosine, leucine, phenylalanine, glutamic acid, isoleucine, valine, methionine, histidine, alanine...

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Abstract

The invention discloses an amino acid composition containing a new antioxidant. The compound amino acid injection (18AA-VII) with different concentrations is characterized by being prepared from 9.10 g of isoleucine, 12.9 g of leucine, 10.00 g of lysine acetate, 4.40 g of methionine, 7.00 g of phenylalanine, 7.5 g of threonine, 1.30 g of tryptophan, 14.00 g of valine, 7.10 g of alanine, 9.00 g of arginine, 1.00 g of aspartic acid, 0.50 g of glutamic acid, 5.00 g of histidine, 5.00 g of proline, 1.70 g of serine, 0.40 g of tyrosine, 7.00 g of glycine 0.35 g of cysteine, 0.20-0.30 g of citric acid and a proper amount of pH regulator. The composition does not contain sulfite antioxidants, the harm of sulfites to human bodies is solved, and thus, the product becomes safer in clinic use. Detection results of accelerated tests show that the stability of the compound amino acid injection is better than or the same to that of like products.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to an amino acid composition containing a novel antioxidant and a preparation method thereof. Background technique [0002] Compound Amino Acid Injection (18AA-VII) is a sterilized aqueous solution prepared from 18 kinds of amino acids plus excipients. It is clinically used as an amino acid supplement, which can regulate nitrogen balance and promote protein synthesis and wound healing. [0003] Since amino acids are very unstable in solution, they are easily oxidized to produce a series of complex substances harmful to the human body. Since the compound amino acid injection was put into production and application in the 1960s, in order to ensure the stability of the product, sulfite compounds with unique antioxidant effects, such as sodium bisulfite and sodium metabisulfite, must be added. [0004] So far, among the compound amino acid injection drugs that have bee...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61K31/405A61K31/401A61K31/198A61K31/195A61K9/08A61K47/12A61K47/20A61P3/02
Inventor 郑飞雄
Owner 郑飞雄
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