11 results about "LYSINE ACETATE" patented technology

The invention discloses a pediatric compound amino acid injection and a preparation method thereof, and relates to the technical field of medicines. The invention relates to a preparation method of a pediatric compound amino acid injection. The preparation method comprises the following steps: carrying out vacuumizing and nitrogen charging treatment on a pipeline and a preparation tank for preparation; the preparation method comprises the following steps: adding low-oxygen injection water into a preparation tank, heating, continuously charging nitrogen, adding isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, valine, histidine, tyrosine, acetyl tyrosine, alanine, arginine, proline, serine, glycine, aspartic acid and taurine, and stirring for dissolving; cooling the preparation tank, adding glacial acetic acid, then adding tryptophan, glutamic acid and cysteine hydrochloride, stirring and dissolving, adding the residual water for injection, and then adding glacial acetic acid to adjust the pH value to obtain a liquid medicine; carrying out intermediate determination on the liquid medicine, filtering, filling, and sealing; and carrying out hot-pressing sterilization on the sealed liquid medicine, and loading the sterilized liquid medicine and an oxygen absorbent into a barrier bag for vacuum packaging. The safety of the compound amino acid can be improved.

The invention belongs to the technical field of nutritional agents, and discloses formula powder containing various amino acids and a preparation method of the formula powder. The formula powder comprises the following components in parts by weight: 20-30 parts of mixed carbohydrate, 10-16 parts of compound amino acid, 20-30 parts of mixed vegetable oil, 0.15-0.5 part of functional fatty acid, 1-5 parts of mineral substances, 2-10 parts of compound nutrients, 0.1-0.5 part of vitamins, 0.1-0.5 part of a functional additive, 0.1-0.5 part of a stabilizer and 0.1-0.5 part of an antioxidant. The compound amino acid is prepared from L-leucine, L-lysine acetate, L-glutamine, L-proline, L-arginine, L-valine, glycine, L-isoleucine, L-aspartic acid, L-threonine and L-methionine, and the compound amino acid is prepared from L-leucine, L-lysine acetate, L-glutamine, L-proline, L-arginine, L-valine, glycine, L-isoleucine, L-aspartic acid, L-threonine and L-methionine. The formula powder provided by the invention is comprehensive in nutrition, high in bioavailability and strong in stability through synergistic proportioning of the compound amino acid and precise addition of the functional fatty acid.

The invention relates to the technical field of amino acid detection, and particularly discloses a method for detecting the content of amino acid in a sodium hyaluronate solution, which is wide in application scene, reliable in determination result and easy to operate. The detection method comprises the following steps: preparing a plurality of standard solutions with different concentrations and containing glycine, proline, alanine, leucine, valine and lysine acetate to obtain a standard series of solutions, and deriving the standard series of solutions to obtain a standard solution to be detected; pretreating and deriving a sodium hyaluronate solution to be detected to obtain a sample to be detected; carrying out liquid chromatography detection on each amino acid in the standard to-be-detected solution and the to-be-detected sample by adopting a liquid chromatography, drawing a standard curve of each amino acid, and calculating a linear regression equation of each standard curve; and calculating the content of each amino acid according to the peak area of each amino acid in the sample and the corresponding linear regression equation.

The invention discloses a preparation method and application of a compound amino acid injection, and the preparation method comprises the following steps: adding water for injection into a closed container filled with protective gas; amino acids including tyrosine, leucine, isoleucine, phenylalanine, aspartic acid, glutamic acid, methionine, tryptophan, valine, threonine, histidine, alanine, glycine, arginine, lysine acetate, proline, serine and cysteine are sequentially added according to the following sequence, and liquid medicine is obtained; and heating and sterilizing the liquid medicine to obtain the compound amino acid injection. Specific amino acid components are added into the closed container filled with protective gas according to a specific sequence, a good anti-oxidation effect can be achieved under the condition that an antioxidant and an adsorbent are not added, and the 18-component compound amino acid injection which is high in active component content, low in impurity content, good in product quality stability and high in clinical use safety is obtained.

The application discloses a compound amino acid injection (15-HBC) composition and a preparation method thereof, and belongs to the technical field of medicines. The compound amino acid injection (15-HBC) composition provided by the application comprises the following components in an amount of 250mL of the composition: isoleucine 1.532-2.298g, leucine 2.756-4.134g, lysine acetate 1.160-1.740g, methionine 0.500-0.750g, phenylalanine 0.640-0.960g, threonine 0.400-0.600g, tryptophan 0.180-0.270g, valine 1.772-2.658g, alanine 0.800-1.200g, arginine 1.160-1.740g, histidine 0.320-0.480g, proline 1.260-1.890g, serine 0.660-0.990g, glycine 0.660-0.990g, cysteine hydrochloride 0.040-0.060g, and appropriate amount of glacial acetic acid for pH adjustment, and the rest is injection water. The application also provides a preparation method of the compound amino acid injection (15-HBC) without sulfite antioxidant. Meanwhile, the activated carbon adsorption process is removed in the preparation, the control of raw material packages, production processes and the like is strengthened to control bacterial endotoxins, the production process is simplified, and the product quality is ensured.

The invention relates to the technical field of hemodialysis, in particular to a compound dialysis composition and a preparation method thereof. The invention provides a compound alpha ketoacid dialysis composition. The compound alpha ketoacid dialysis composition comprises calcium racemic ketoisoleucine, calcium ketoleucine, calcium ketophenylalanine, calcium ketovaline, calcium racemic methionine, L-lysine acetate, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium diacetate and sodium bicarbonate. According to the invention, the compound alpha keto acid component is added into the hemodialysis liquid, so that toxin removal and nutrition supplement can be realized at the same time when a patient is subjected to hemodialysis, a good treatment effect is achieved, and meanwhile, the pain caused by taking a large amount of medicine every day is avoided. Meanwhile, stimulation and damage to intestines and stomach can be avoided by avoiding oral administration, and the appetite of a patient is improved.

The invention discloses an organ maintenance liquid for repairing liver functions as well as a preparation method and application of the organ maintenance liquid. The feed additive comprises the following components: an oxygen-carrying component, succinyl gelatin, sodium chloride, sodium hydroxide, sodium bicarbonate, calcium gluconate, magnesium sulfate, chromium chloride, copper chloride, ferric chloride, manganese chloride, sodium molybdate, sodium selenite, zinc chloride, potassium iodide, sodium fluoride, isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, tryptophan, serine, valine and histidine. The injection is prepared from arginine, alanine, asparaginic acid, cysteine, glutamic acid, proline, tyrosine, glycine, sodium hydrogen sulfite, heparin, methylprednisolone sodium succinate, broad-spectrum antibiotics, antifungal drugs, FXR agonists and sterilized water for injection. The oxygen-carrying component is washed red blood cells or concentrated red blood cells or artificial blood. The viscosity of the organ maintenance liquid is closer to that of plasma, the influence on the blood coagulation function and the renal function is avoided, and the organ maintenance liquid has higher safety, can treat ischemia reperfusion injury, repair the liver biliary tract function and remarkably reduce various inflammation indexes, and is used for ischemia-free liver transplantation.

The present invention relates to the technical field of pharmaceuticals. Disclosed are a pediatric compound amino acid injection and a preparation method therefor. The preparation method for a pediatric compound amino acid injection comprises the following steps: vacuuming and nitrogen purging a tube and preparation tank used for formulation, adding low-oxygen water for injection into the preparation tank, heating and continuously purging with nitrogen, adding isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, valine, histidine, tyrosine, acetyltyrosine, alanine, arginine, proline, serine, glycine, aspartic acid, and taurine, and stirring to dissolve, cooling the preparation tank, adding glacial acetic acid, then adding glutamyl-tryptophan, glutamic acid, and cysteine hydrochloride, stirring to dissolve, adding the remaining water for injection, then adding glacial acetic acid to adjust the pH, to obtain a medicament solution; performing intermediate measurement of the medicament solution, filtering and then filling and sealing, sterilizing the sealed medicament solution by heat pressurization, and placing, together with an oxygen-absorbing agent, in a barrier bag and vacuum sealing. The present invention can improve the safety of the compound amino acid injection.

The application discloses a refining method of L-lysine acetate. The fermentation liquor is pretreated by membrane separation in the application, and the cell protein, pigment and inorganic salt in the fermentation liquor are removed, so that the subsequent crystallization load is reduced by 40%. When crystallization is carried out, a pulse gradient cooling method is adopted, and ultrasonic assistance is combined, so that the crystallization time is greatly shortened, the crystal type is good, and the crystal morphology is hexagonal flaky. Further refining is carried out, so that the product purity is increased to more than 99.8%, and the single impurity content is less than 0.1%. The application realizes efficient purification and industrial production of L-lysine acetate.

The invention belongs to the technical field of nutritional compositions, and particularly relates to a composition for promoting growth and development and improving cold symptoms and a preparation method and application thereof. The composition comprises skimmed milk powder, whole milk powder, demineralized whey powder, lactose, isomaltooligosacharide, crystalline fructose, bovine colostrum powder, milk mineral salt, galactooligosaccharide, fructooligosaccharide, colostrum basic protein, hydrolyzed yolk powder, phospholipid, xanthophyll, calcium carbonate, choline chloride, L-carnitine, compound vitamins, compound minerals, L-arginine and L-lysine acetate. The lactobacillus plantarum beverage is prepared from lactobacillus plantarum, gamma-aminobutyric acid, lactobacillus plantarum YBT5, lactobacillus plantarum SG5, bifidobacterium animalis subsp. Lactis HN019 and lactobacillus acidophilus NCFM. The composition has dual effects of promoting growth and development and resisting cold, and has important application prospects in improving nutrition and health conditions of people and preventing inflammation-related diseases.

The invention discloses a method for refining L-lysine acetate. According to the method, the fermentation liquor is pretreated through membrane separation, mycoprotein, pigment and inorganic salt in the fermentation liquor are removed, and the follow-up crystallization load is reduced by 40%; during crystallization, a pulse type gradient cooling method is adopted, and ultrasonic assistance is combined, so that the crystallization time is greatly shortened, the crystal form is relatively good, and the crystal is in a hexagonal sheet shape; further refining is carried out, the product purity is improved to 99.8% or above, and the single impurity content is 1t; and 0.1%. The method provided by the invention realizes efficient purification and industrial production of L-lysine acetate.