60 results about "LYSINE ACETATE" patented technology

The present invention relates to medicine composition of aescin and its preparation process and use. The aescin with purity over 90 % may be compounded with medicine carrier to form medicine composition with high synergistic effect, obviously reduced irritation on blood vessel and muscle, obviously raised medicinal effects of resisting inflammation, resisting exudation, improving blood circulation, etc. The medicine composition has low irritation, high safety, high therapeutic index and other features.

The invention discloses a pharmaceutical composition containing 18 amino acids. The pharmaceutical composition is characterized in that a compound amino acid injection (18AA-II) with varied concentration is prepared by using the following components according to the following ratios of parts by weight: 1.50 of aspartic acid, 2.50 of glutamic acid, 1.90 of serine, 3.00 of histidine, 3.50 of glycine, 2.50 of threonine, 7.20 of alanine, 4.90 of arginine, 0.20 of tyrosine, 0.20 of cystine, 3.20 of valine, 2.50 of methionine, 0.85 of tryptophan, 3.50 of phenylalanine, 2.50 of isoleucine, 3.40 of leucine, 5.50 of lysine acetate, 2.90 of proline, 0.10 of cysteine hydrochloride and 0.20 of lemon acid. The composition does not contain a sulfite antioxidant so that the pharmaceutical composition is clinically used in a safer manner. After an accelerated test, a test result shows that the pharmaceutical composition containing 18 amino acids is as stable as or more stable than like products which are sold in the markets and contain sulfites.

The invention discloses an alfalfa seed obducens agent which is prepared from the following raw materials in percentage by weight: 1.5-5% of carboxymethylcellulose, 0.5-3% of rhizobium of alfalfa, 0.5-7% of biological humic acid, 0.2-3% of urea, 0.2-3% of monopotassium phosphate, 0.1-0.7% of ammonium molybdate, 0.1-0.5% of borax, 2-6% of sulfur powder, 0.15-0.7% of ferrous sulfate, 5-8% of sodium polyacrylate, 0.01-0.05% of indolebutyric acid, 0.01-0.05% of gibberellin, 0.01-0.05% of lysine acetate, 1.0-8.0% of thiram, 2.0-8.5% of thiophanate-methyl and the balance of alfalfa seeds. Aiming to the characteristics that alfalfa in the seedling stage is not saline-alkaline tolerant, draught tolerant, susceptible to diseases and the like, anti-salt and alkali, anti-drought and soil sterilizing factors are respectively added into the obducens agent disclosed by the invention, and moreover, the alfalfa seed obducens agent is obvious in production and application effects and is deeply welcomed by farmer households.

The present invention relates to aescin medicine composition and its preparation process and use. The aescin product of purity over 90 % may be compounded with medicine carrier to form composition with obvious synergistic effect, reduced stimulation of aescin on blood vessels and muscles, and obviously raised effects of diminishing inflammation, antagonizing effusion, improving blood circulation, etc. The composition features its less stimulation, high safety, high treating index, etc.

The invention discloses an amino acid injection, commonly known as propranolol, which relates to a pharmaceutical preparation containing 18 kinds of amino acids. The amino acid injection contains the following components per 1,000 milliliters: isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan, valine, glycine, alanine, glutamic acid, aspartic acid, proline, serine, cystine, lysine hydrochloride or lysine acetate, arginine hydrochloride or arginine, histidine hydrochloride or histidine, tyrosine or acetyl tyrosine, and sodium bisulfite or sodium meta-bisulphite. The osmotic pressure ratio of the amino acid injection is lower than 1.8, which effectively reduces the pain for a patient in infusion; the added quantity of antioxidant is small, which can reduce the clinical adverse reactions; and an infusion bottle body is large, which is convenient to mix liquid in clinical application.

The invention discloses compound alpha-keto acid tablets and a preparation method and a detection method thereof. The preparation method comprises the following steps of: taking calcium 3-methyl-2-oxovalerate, ketoleucine calcium, alpha-ketophenylalanine calcium, keto-valine-calcium, D,L-alpha-hydroxymethionine calcium, lysine acetate, threonine, tryptophan, histidine and tyrosine, crushing the main medicaments respectively and sieving with a sieve of 100 meshes; sieving starch, talc powder and magnesium stearate and sieving with a sieve of 80 meshes respectively; mixing the main medicaments and the starch uniformly, preparing a soft material from 6 percent polyvinyl pyrrolidone (PVP) k30 isopropanol solution, granulating with a sieve of 20 meshes, and drying at the temperature of 40 DEG C; reshaping, adding magnesium stearate, the talc powder and crosslink povidone, and mixing uniformly; detecting an intermediate, and tabletting; and coating, and thus obtaining the compound alpha-keto acid tablets. The tablets with excellent granule pressing property, flowability, hardness and dissolution degree can be prepared by using the method, and the detection method can further ensure the quality of the prepared compound alpha-keto acid tablets.

The invention relates to a pharmaceutical composition containing 17 amino acids. The pharmaceutical composition comprises the following raw materials and auxiliary materials: proline, serine, alanine, isoleucine, leucine, tyrosine, glutamic acid, phenylalanine, arginine, lysine acetate, valine, threonine, histidine, tryptophan, methionine, acetylcysteine, glycine, sorbitol, and sodium bisulfite. The product is free of chlorine ion, and is wider in application crowd range; in the production, an acid or a base is not additionally added for adjusting the PH value; and the product is prepared according to the component ratio, and has the PH value of 5.5-7.0. Therefore, the pharmaceutical composition meets the pharmaceutical registering requirements that the material consumption is reduced andthe production cost is lower, and has equivalent or better quality and stability as compared with the commercially available products.

The invention provides a composition containing eighteen amino acids and a preparation method of the composition. The composition is a composite amino acid injection solution 18AA-II and comprises the following components by weight: 1.5-3.3g of aspartic acid, 2.5-5.7g of glutamic acid, 1.9-4.5g of serine, 3.0-6.8g of histidine, 3.5-7.9g of glycine, 2.5-5.7g of threonine, 7.2-16.3g of alanine, 4.9-11.2g of arginine, 0.2-0.3g of tyrosine, 0.16-0.2g of cystine, 3.2-7.3g of valine, 2.5-5.7g of methionine, 0.85-1.9g of tryptophane, 3.5-7.9g of phenylalanine, 2.5-5.7g of isoleucine, 3.4-7.9g of leucine, 5.5-12.7g of lysine acetate, 2.9-6.8g of proline, 1.3-2.75ml of glacial acetic acid, 0.2g of cysteine and 0.05g of calcium disodium edetate. The composition does not contain a sulfite antioxidant so that the obtained product can be more safely used clinically.

The invention discloses a method for producing lysine acetate for injection, comprising the following steps of: preparing industrial hydrochloric acid lysine into aqueous solution; after adsorbing and saturating through balanced hole strong acid cation exchange resin; using 0.01-0.05 mol/L of ammonia water to elute neutral amino acid heteroacid; then, using 0.5-1 mol/L of ammonia water to elute histidine; finally, using 1.5-5 mol/L of ammonia water to elute lysine; filtering through an ultra-filtration membrane; filtering through a nano-filtration membrane; concentrating and crystallizing; and obtaining the lysine acetate for injection. The better separation effect and production efficiency can be achieved. The contents of the amino acid heteroacid and bacterial endotoxin in the product are very low. The light transmission rate of the solution is greatly improved. The purity of the product can reach above 99.8%. The quality exceeds the quality standard for injection of Chinese pharmacopoeia.

The invention relates to a compound amino acid injection (18AA-I) composition. Each 1000ml of the compound amino acid injection composition contains 2.8-3.5g of isoleucine, 3.5-4.0g of serine, 1.7-2.5g of glycine, 6.0-6.5g of lactamine, 1-1.5g of methionine, 1-1.5g of tryptophan, 6.5-7.5g of leucine, 3.7-4.3g of aspartic acid, 0.5-1.0g of N-acetyl-L-tyrosine, 5.2-5.8g of proline, 2.5-3.0g of phenylalanine, 3.1-3.8g of valine, 7.7-8.3g of lysine acetate, 6.8-7.3g of glutamic acid, 1.7-2.5g of histidine, 3.7-4.5g of arginine, 3.4-4.0g of threonine and 0.5-1.5g of cysteine hydrochloride and is characterized in that each 1000ml of the injection further contains 0.5-1g of lactic acid.

The invention relates to a preparation method of compound amino acid (15) dipeptide (2) injecta, specifically comprising the following steps of: under the whole-course protection of nitrogen, taking water for injection with a certain quantity, sequentially adding glycyl-L-glutamine, glycyl-L-tyrosine and arginine with prescription quantity, stirring and dissolving, clearly dissolving, adding aspartate, glutamic acid, leucine, isoleucine and phenylalanine with prescription quantity which is not less than 60 screen meshes, dissolving and clearly dissolving, adding alanine, histidine, L-lysine monoacetate, methionine, proline, serine, threonine, tryptophan and valine with prescription quantity, stirring and clearly dissolving, adjusting the pH at 5.4-5.8 by citric acid, adding full dose of 0.10% (w/v) of activated carbon, stirring for 30min under the temperature of 60DEG C, fixing the volume to total volume by the water for injection after filtering in a decarbonizing way, sieving by a filter membrane with 0.22 micrometers, filling, charging nitrogen, adding a plug, pricking an aluminum cap, and sterilizing for 8-12min in a hot-press way under the temperature of 121DEG C (F0 value is larger than 8), wherein the quality of the injecta can achieve the quality standard of an imported drug of the finished product of the German Fresenius Corporation.

The invention discloses a compound amino acid injection (18AA-IV) composition, each 1000ml of which comprises 4.0-4.5g of leucine, 1.5-2.0g of isoleucine, 4.0-4.5g of lysine acetate, 1.0-1.5g of methionine, 1.8-2.2g of histidine, 0.10-0.15g of tyrosine, 1.8-2.3g of alanine, 3-4g of glycine, 1.0-1.5g of aspartate, 2.0-2.5g of glutamic acid, 1.0-1.5g of proline, 3.0-3.5g of phenylalanine, 2.0-2.5g of threonine, 0.3-0.8g of N-acetyl L-acetyl, 1-2g of valine, 0.5-1g of serine, 2-3g of arginine, 0.2-0.7g of cysteine hydrochloride and 70-80g of glucose. The compound amino acid injection (18AA-IV) composition is characterized by containing 0.5-5g of citric acid per 1000ml.

The invention provides a preparation method of medicine grade lysine acetate, which comprises the following steps: 1) enabling a biological fermentation broth containing L-lysine to be reacted with acetic acid, adding activated carbon into reaction solution for performing decolorization at least once, then concentrating, crystallizing and getting a lysine acetate crude product; and 2) adding the lysine acetate crude product obtained in the step 1) into distilled water for dissolution, performing the decolorization at least once, and further performing fine filtration, concentration and crystallization. Various indicators of the medicine grade lysine acetate prepared according to the invention are in line with the pharmacopoeia standard, the preparation of the medicine grade lysine acetate by using the lysine fermentation broth has no harsh reaction conditions and is applicable to industrial production, and the preparation of the medicine grade lysine acetate by using the lysine fermentation broth which is relatively low in price can realize value appreciation to the maximum extent.

The invention discloses a compound amino acid dipeptide injection. The compound amino acid dipeptide injection is prepared from the following components in pats by weight: 4-8 parts of alanine, 2-6 parts of arginine, 0.7-2.7 parts of aspartic acid, 0.9-1.3 parts of glutamic acid, 1-5 parts of histidine, 0.9-1.3 parts of isoleucine, 1.6-5.6 parts of leucine, 2.5-6.5 parts of lysine acetate, 0.9-1.3parts of methionine, 1.2-5.2 parts of phenylalanine, 1-5 parts of proline, 0.8-2.8 parts of serine, 0.9-1.3 parts of threonine, 0.3-2.3 parts of tryptophan, 0.85-1.35 parts of valine, 8-16 parts of glycylglutamine, 0.75-2.75 parts of glycyltyrosine, 0.5-2.5 parts of a PH regulator, 20-38 parts of water and 0.1-0.3 part of an adsorbent. The invention further provides a preparation method of the compound amino acid dipeptide injection. Glutamine is generated by the glycyltyrosine, the generated glutamine repairs a postoperative wound, compound amino acid has a better effect of promoting wound healing, the healing time of a postoperative patient is shortened, and the healing promoting effect is better.

The invention discloses a pharmaceutical composition containing 19 types of amino acids and a preparation method thereof. The pharmaceutical composition comprises tyrosine, leucine, isoleucine, phenylalanine, aspartic acid, valine, threonine, proline, methionine, glutamic acid, lysine acetate, arginine, alanine, glycine, histidine, serine, tryptophan, cysteine, taurine, a pH value conditioning agent, and water. The pharmaceutical composition can be free of sulfites, thereby completely eliminates the safety hazards of sulfites to the human body, and makes the clinical use safer; and the expiration period of the composition is longer.

The invention provides a compound amino acid solution for a tree nutrient solution and a preparation process thereof. Specifically, the compound amino acid solution for the tree nutrient solution comprises the following components by mass: 1000 parts of deionized water, 0.20-0.30 part of tyrosine, 4.80-5.00 parts of leucine, 3.48-3.56 parts of isoleucine, 3.50-3.70 parts of valine, 2.21-2.29 parts of methionine, 1.92-2.08 parts of alanine, 5.23-5.43 parts of phenylalanine, 0.71-0.79 part of glutamic acid, 2.42-2.58 parts of aspartic acid, 4.22-4.36 parts of lysine acetate, 2.42-2.58 parts of threonine, 7.54-7.66 parts of glycine, 0.90-1.10 parts of proline, 0.90-1.10 parts of serine, 4.82-5.12 parts of arginine hydrochloride, 2.41-2.62 parts of histidine hydrochloride, 0.82-0.98 part of tryptophan and 0.007-0.012 part of cystine. The compound amino acid provided by the invention is accord with the growth requirements of malnourished trees, and by setting the preparation process of the compound amino acid solution, a compound amino acid solution sample with high stability can be obtained, thus avoiding great loss of the raw and auxiliary materials in the making process of the compound amino acid solution.

A lysine acetate mother liquid recycling method comprises the following steps of: 1) alcohol recycle: adding sodium hydroxide and EDTA-2Na (ethylenediamine tetraacetic acid disodium salt) into a lysine acetate mother liquid till the pH value of the mother liquid is 7.0-8.0, distilling the mother liquid, detecting and recycling the distilled alcohol, and storing the distillation tail liquid for use; and 2) lysine recycle: adding drinking water into the tail liquid in the step 1 for diluting the tail liquid until the concentration reaches 7%, regulating the pH value to 3.0-4.0, selectively adsorbing lysine in the tail liquid by using resin, desorbing, decolorizing, concentrating, and refining the tail liquid to obtain the lysine acetate. By the lysine acetate mother liquid recycling method, through treatment of the lysine acetate mother liquid, qualified alcohol and lysine acetate finished products are recycled, so that the production cost is effectively reduced, resources are saved and the production efficiency is improved.

The invention relates to a compound amino acid injection and a preparation method thereof. Every 1,000 mL of the injection contains 9-12 g of isoleucine, 12.5-15 g of leucine, 9-10.5 g of lysine acetate, 4-4.5 g of methionine, 6.5-7 g of phenylalanine, 7-7.5 g of threonine, 1-1.3 g of tryptophan, 14-16 g of valine, 6.5-7.5 g of alanine, 9-10 g of arginine, 0.8-1 g of aspartic acid, 0.3-0.8 g of glutamic acid, 4.5-5 g of histidine, 4.5-5 g of praline, 1.5-1.8 g of serine, 0.4-0.6 g of tyrosine, 6.5-7 g of glycine, 0.3-0.5 g of cysteine and 0.01-0.3 g of an antioxidant. Accordingly, the amino acid supplementing and absorbing effects are improved, a user can keep vigorous, the time needed when a large amount of injection is injected is shortened, drug stimulation generated when a large amount of injection is injected is reduced, the defects of an existing amino acid injection are greatly overcome, and the advantages of being reasonable in formula, durable in effect and good in human body absorption and health care effect are achieved.

The invention discloses a compound amino acid injection, which is prepared from, by weight according to a formula, 0.40-0.60 part of aspartic acid, 0.40-0.60 part of glutamic acid, 1.00-3.00 parts ofserine, 2.00-4.00 parts of glycine, 4.00-6.00 parts of threonine, 5.00-7.00 parts of alanine, 5.00-7.00 parts of arginine, 0.80-1.20 parts of tyrosine, 12.00-18.00 parts of valine, 8.00-12.00 parts ofmethionine, 8.00-12.00 parts of phenylalanine, 12.00-18.00 parts of isoleucine, 18.00-22.00 parts of leucine, 13.00-15.00 parts of lysine acetate, 3.00-5.0 parts of proline, 4.00-6.00 parts of histidine, 5.00-6.00 parts of tryptophan, 0.40-0.60 part of cysteine, 0.40-0.60 part of sodium bisulfite, 120.00-180.00 parts of glacial acetic acid, and 1500-1700 parts of water for injection. The preparation process provided by the invention has shorter preparation time, and is suitable for preparing a qualified and stable preparation.