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Composition containing eighteen amino acids

A composition and amino acid technology, applied in the directions of drug combination, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of affecting calcium ion level and inappropriateness, and achieve the effect of eliminating toxic side effects and simple process

Active Publication Date: 2012-10-24
武汉天安医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But we should see that the national standard formula of Compound Amino Acid Injection 18AA-II does not contain chloride ions, and it is inappropriate to choose cysteine ​​hydrochloride
In addition, citric acid, as an uncommon metal chelator, can affect the level of calcium ions in the blood during use, and there is a certain risk

Method used

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  • Composition containing eighteen amino acids
  • Composition containing eighteen amino acids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1, the prescription of composition is as follows:

[0042] Aspartic acid 1.5kg, glutamic acid 2.5kg

[0043] Serine 1.9kg, Histidine 3.0kg

[0044] Glycine 3.5kg, Threonine 2.5kg

[0045] Alanine 7.2kg, Arginine 4.9kg

[0046] Tyrosine 0.2kg, cystine 0.16kg

[0047] Valine 3.2kg, Methionine 2.5kg

[0048] Tryptophan 0.85kg, Phenylalanine 3.5kg

[0049] Isoleucine 2.5kg, Leucine 3.4kg

[0050] Lysine acetate 5.5kg, proline 2.9kg

[0051] Glacial acetic acid 1300ml, cysteine ​​0.2kg

[0052] Calcium and sodium edetate 0.01kg, appropriate amount of water to 1000000ml.

[0053] Add about 600,000 ml of water for injection into the concentrated mixing tank, fill with nitrogen, heat to boiling and keep for 15 minutes, stop heating, and put in the above-mentioned raw and auxiliary materials in order by weight: calcium sodium edetate, cystine, tyrosine, leucine amino acid, isoleucine, valine, methionine, phenylalanine, glutamic acid, aspartic acid, lysine ace...

Embodiment 2

[0054] Embodiment 2, the prescription of composition is as follows:

[0055] Aspartic acid 2.5kg, glutamic acid 4.2kg

[0056] Serine 3.4kg, Histidine 5.0kg

[0057] Glycine 5.9kg, Threonine 4.2kg

[0058] Alanine 12.2kg, Arginine 8.4kg

[0059] Tyrosine 0.2kg, cystine 0.2kg

[0060] Valine 5.5kg, Methionine 4.2kg

[0061] Tryptophan 1.4kg, Phenylalanine 5.9kg

[0062] Isoleucine 4.2kg, Leucine 5.9kg

[0063] Lysine acetate 9.5kg, proline 5.0kg

[0064] Glacial acetic acid 2500ml, cysteine ​​0.2kg

[0065] Calcium and sodium edetate 0.05kg, appropriate amount of water to 1000000ml.

[0066] Add about 600,000 ml of water for injection into the concentrated mixing tank, fill with nitrogen, heat to boiling and keep for 15 minutes, stop heating, and put in the above-mentioned raw and auxiliary materials in order by weight: calcium sodium edetate, cystine, tyrosine, leucine amino acid, isoleucine, valine, methionine, phenylalanine, glutamic acid, aspartic acid, lysine acet...

Embodiment 3

[0067] Embodiment 3, the prescription of composition is as follows:

[0068] Aspartic acid 3.3kg, glutamic acid 5.7kg

[0069] Serine 4.5kg, Histidine 6.8kg

[0070] Glycine 7.9kg, Threonine 5.7kg

[0071] Alanine 16.3kg, Arginine 11.2kg

[0072] Tyrosine 0.3kg, cystine 0.2kg

[0073] Valine 7.3kg, Methionine 5.7kg

[0074] Tryptophan 1.9kg, Phenylalanine 7.9kg

[0075] Isoleucine 5.7kg, Leucine 7.9kg

[0076] Lysine acetate 12.7kg, proline 6.8kg

[0077] Glacial acetic acid 2750ml, cysteine ​​0.2g

[0078] Calcium and sodium edetate 0.1kg, appropriate amount of water to 1000000ml.

[0079] The preparation method is the same as in Example 1.

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Abstract

The invention provides a composition containing eighteen amino acids and a preparation method of the composition. The composition is a composite amino acid injection solution 18AA-II and comprises the following components by weight: 1.5-3.3g of aspartic acid, 2.5-5.7g of glutamic acid, 1.9-4.5g of serine, 3.0-6.8g of histidine, 3.5-7.9g of glycine, 2.5-5.7g of threonine, 7.2-16.3g of alanine, 4.9-11.2g of arginine, 0.2-0.3g of tyrosine, 0.16-0.2g of cystine, 3.2-7.3g of valine, 2.5-5.7g of methionine, 0.85-1.9g of tryptophane, 3.5-7.9g of phenylalanine, 2.5-5.7g of isoleucine, 3.4-7.9g of leucine, 5.5-12.7g of lysine acetate, 2.9-6.8g of proline, 1.3-2.75ml of glacial acetic acid, 0.2g of cysteine and 0.05g of calcium disodium edetate. The composition does not contain a sulfite antioxidant so that the obtained product can be more safely used clinically.

Description

technical field [0001] The invention relates to a composition containing eighteen kinds of amino acids for injection (namely, compound amino acid injection 18AA-II) and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Compound Amino Acid Injection (18AA-II) is a sterilized aqueous solution prepared from 18 kinds of amino acids plus auxiliary materials. It is clinically used as amino acid supplement. Infusion of this product to meet the needs of the body to synthesize protein. [0003] Since amino acids are unstable in aqueous solution, they are easily oxidized to produce a series of complex substances harmful to human body. The production of compound amino acid injection at home and abroad is mainly to add sulfite (sodium bisulfite or sodium metabisulfite, etc.) antioxidants, and carry out nitrogen flushing protection in the whole process. [0004] Sulfite antioxidants have many adverse reactions, the most c...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61K9/08A61K47/18A61P3/02A61K31/405A61K31/198A61K31/197A61K31/195
Inventor 肖云彩杜勇
Owner 武汉天安医药科技有限公司
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