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Compound amino acid injection (18AA-IV) composition

A compound amino acid, injection technology, applied in drug combination, metabolic diseases, peptide/protein components, etc., can solve problems such as harm to patients, affecting product qualification rate, unqualified antihypertensive substances, etc.

Inactive Publication Date: 2013-03-27
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such as antibiotics, traditional Chinese medicine injections, amino acids, polypeptides, etc., compound amino acid injection (15HBC), as an injection containing histidine in the formula, after heat sterilization, its antihypertensive substances are prone to unqualified problems. Affect the qualification rate of the product, and easily cause potential harm to patients, so reducing the content of its antihypertensive substances has become a problem to be solved in the prior art

Method used

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  • Compound amino acid injection (18AA-IV) composition

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Embodiment Construction

[0015] In the embodiment, the prescription in the following table is the feed amount calculated by 10000ml, and the subpackage adopts 250ml glass bottle. Sterilization was performed by autoclaving at 105°C for 45 minutes. After adding the pH regulator, adjust the pH to 5.0-5.5 with 0.1M sodium hydroxide solution or hydrochloric acid. (If the pH is qualified, you don’t need to add more)

[0016] Described injection adopts following method to prepare

[0017] 1) Take 15-25% of the prescribed amount of water for injection, put in the prescribed amount of glucose to dissolve, add 0.2% (g / ml) medicinal charcoal, stir and place for 30 minutes, and set aside.

[0018] 2) Take 35% to 45% of the prescribed amount of water for injection, under the protection of nitrogen, heat to 40~60°C, add arginine, tyrosine, isoleucine, valine, proline, leucine Acid, Lysine Acetate, Methionine, Threonine, Alanine, Glutamic Acid, Aspartic Acid, Serine, N-Acetyl-L-Tryptophan, Glycine, Phenylalanine,...

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Abstract

The invention relates to a compound amino acid injection (18AA-IV) composition. Each 1000ml of the compound amino acid injection composition contains 4.0-4.5g of leucine, 1.5-2.0g of isoleucine, 4.0-4.5g of lysine acetate, 1.0-1.5g of methionine, 1.8-2.2g of histidine, 0.10-0.15g of tyrosine, 1.8-2.3g of alanine, 3-4g of glycine, 1.0-1.5g of aspartic acid, 2.0-2.5g of glutamic acid, 1.0-1.5g of proline, 3.0-3.5g of phenylalanine, 2.0-2.5g of threonine, 0.3-0.8g of N-acetyl-L-tyrosine, 1-2g of valine, 0.5-1g of serine, 2-3g of arginine, 0.2-0.7g of cysteine hydrochloride and 70-80g of glucose and is characterized in that each 1000ml of the injection further contains 0.5-1g of lactic acid.

Description

Technical field: [0001] The invention relates to an amino acid-containing injection and a manufacturing method thereof. Background technique: [0002] Amino acids are the basic units that make up proteins. Compound amino acid injection, as a nutritional supplement for intravenous injection, is widely used in nutritional support therapy, such as the existing 18 kinds of amino acid compound injection with the general name of compound amino acid injection (18AA-IV), its formula is to contain bright Amino acid 4.17g, isoleucine 1.87g, lysine acetate 4.13g, methionine 1.17g, histidine 2.00g, tyrosine 0.116g, alanine 2.07g, glycine 3.57g, asparagine Amino acid 1.27g, glutamic acid 2.17g, proline 1.10g, phenylalanine 3.11g, threonine 2.17g, N-acetyl L-tryptophan 0.52g, valine 1.50g, serine 0.73g , arginine 2.63g, cysteine ​​hydrochloride 0.48g, glucose 75g, sodium metabisulfite 1.0g, according to the existing regulations, those from animals and plants, microbial fermentation extr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4172A61K31/405A61K31/401A61K31/198A61K31/195A61K47/12A61P3/02
Inventor 何光杰袁英凌可均常翔
Owner TIANJIN JINYAO GRP
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