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Compound amino acid injection

A compound amino acid, injection technology, applied in pharmaceutical formulations, anhydride/acid/halide active ingredients, metabolic diseases, etc., to achieve the effects of short preparation time, shortened preparation time, and low preparation temperature

Inactive Publication Date: 2020-02-28
天津金耀集团湖北天药药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the compound amino acid injection (18AA) based on this prescription has been clinically used for many years, due to the chemical properties of the amino acid itself, there are still many deficiencies in the products prepared with this marketed prescription.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The present invention proposes a compound amino acid injection, the formula of its raw materials by weight is as follows: 0.40 parts of aspartic acid, 0.40 parts of glutamic acid, 1.00 parts of serine, 2.00 parts of glycine, 4.00 parts of threonine, 5.00 parts of alanine 5.00 parts of arginine, 0.80 parts of tyrosine, 12.00 parts of valine, 8.00 parts of methionine, 8.00 parts of phenylalanine, 12.00 parts of isoleucine, 18.00 parts of leucine, lysine acetate 13.00 parts of acid, 3.00 parts of proline, 4.00 parts of histidine, 5.00 parts of tryptophan, 0.40 parts of cysteine, 0.40 parts of sodium bisulfite, 120.00 parts of glacial acetic acid, and 1500 parts of water for injection.

[0024] The present invention also provides a preparation process of compound amino acid injection, comprising the following steps:

[0025] (1), select glacial acetic acid and 36% water for injection, and prepare it into a 36% aqueous solution for adjusting the pH value of the medicinal sol...

Embodiment 2

[0034] The present invention proposes a compound amino acid injection, the formula of its raw materials by weight is as follows: 0.50 parts of aspartic acid, 0.50 parts of glutamic acid, 2.00 parts of serine, 3.00 parts of glycine, 5.00 parts of threonine, 6.00 parts of alanine 6.00 parts of arginine, 1.00 parts of tyrosine, 15.00 parts of valine, 10.00 parts of methionine, 10.00 parts of phenylalanine, 15.00 parts of isoleucine, 20.00 parts of leucine, lysine acetate 14.00 parts of acid, 4.00 parts of proline, 5.00 parts of histidine, 5.40 parts of tryptophan, 0.50 parts of cysteine, 0.50 parts of sodium bisulfite, 150.00 parts of glacial acetic acid, and 1600 parts of water for injection.

[0035] The present invention also provides a preparation process of compound amino acid injection, comprising the following steps:

[0036] (1), select glacial acetic acid and 36% water for injection, and prepare it into a 36% aqueous solution for adjusting the pH value of the medicinal s...

Embodiment 3

[0045] The present invention proposes a compound amino acid injection, the formula of its raw materials by weight is as follows: 0.60 parts of aspartic acid, 0.60 parts of glutamic acid, 3.00 parts of serine, 4.00 parts of glycine, 6.00 parts of threonine, 7.00 parts of alanine 7.00 parts of arginine, 1.20 parts of tyrosine, 18.00 parts of valine, 12.00 parts of methionine, 12.00 parts of phenylalanine, 18.00 parts of isoleucine, 22.00 parts of leucine, lysine acetate 15.00 parts of acid, 5.00 parts of proline, 6.00 parts of histidine, 6.00 parts of tryptophan, 0.60 parts of cysteine, 0.60 parts of sodium bisulfite, 180.00 parts of glacial acetic acid, and 1700 parts of water for injection.

[0046] The present invention also provides a preparation process of compound amino acid injection, comprising the following steps:

[0047] (1), select glacial acetic acid and 36% water for injection, and prepare it into a 36% aqueous solution for adjusting the pH value of the medicinal s...

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PUM

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Abstract

The invention discloses a compound amino acid injection, which is prepared from, by weight according to a formula, 0.40-0.60 part of aspartic acid, 0.40-0.60 part of glutamic acid, 1.00-3.00 parts ofserine, 2.00-4.00 parts of glycine, 4.00-6.00 parts of threonine, 5.00-7.00 parts of alanine, 5.00-7.00 parts of arginine, 0.80-1.20 parts of tyrosine, 12.00-18.00 parts of valine, 8.00-12.00 parts ofmethionine, 8.00-12.00 parts of phenylalanine, 12.00-18.00 parts of isoleucine, 18.00-22.00 parts of leucine, 13.00-15.00 parts of lysine acetate, 3.00-5.0 parts of proline, 4.00-6.00 parts of histidine, 5.00-6.00 parts of tryptophan, 0.40-0.60 part of cysteine, 0.40-0.60 part of sodium bisulfite, 120.00-180.00 parts of glacial acetic acid, and 1500-1700 parts of water for injection. The preparation process provided by the invention has shorter preparation time, and is suitable for preparing a qualified and stable preparation.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a compound amino acid injection. Background technique [0002] The compound amino acid injection containing 18 kinds of amino acids is a very important amino acid supplement, which is clinically used for patients who cannot take in enough protein through the gastrointestinal tract. At present, there are many kinds of 18 kinds of amino acid injections clinically, among which compound amino acid injection (18AA) is the most widely used balanced amino acid injection in clinical practice. In terms of prescription components, the listed products all contain 8 essential amino acids: valine, isoleucine, leucine, phenylalanine, methionine, tryptophan, threonine, lysine, glycine, Alanine, proline, serine, glutamic acid, and aspartic acid are 6 non-essential amino acids, and arginine, histidine, tyrosine, and cystine are 4 semi-essential amino acids. Although the comp...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K9/08A61K31/19A61K31/198A61K31/401A61K31/405A61K31/4172A61P3/02
CPCA61K9/0019A61K9/08A61K31/19A61K31/198A61K31/401A61K31/405A61K31/4172A61K33/04A61P3/02A61K2300/00
Inventor 曹琦
Owner 天津金耀集团湖北天药药业股份有限公司
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