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Compound amino acid injection (18AA-IV) composition

A technology for compound amino acids and injections, which can be used in drug combinations, metabolic diseases, peptide/protein components, etc., and can solve problems such as unspecified quantitative detection standards

Inactive Publication Date: 2013-03-20
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, according to the national standard (WS1-(X-314)-2003Z) of compound amino acid injection (18AA-IV), there is no standard for quantitative detection of its HMF content, and only the use of injection equivalent to 1g of glucose is specified. After extraction with ether, it reacts with acidified resorcinol and only shows a slight pink color

Method used

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  • Compound amino acid injection (18AA-IV) composition

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Embodiment Construction

[0015] In the embodiment, the prescription in the following table is the feed amount calculated by 10000ml, and the subpackage adopts 250ml glass bottle. Sterilization is performed by autoclaving at 105°C for 40 minutes.

[0016] Described injection adopts following method to prepare

[0017] 1) Take 15-25% of the prescribed amount of water for injection, put in the prescribed amount of glucose to dissolve, add a pH regulator and 0.2% (g / ml) medicinal charcoal, stir and place it for 30 minutes before use.

[0018] 2) Take 35% to 45% of the prescribed amount of water for injection, under the protection of nitrogen, heat to 40~60°C, add arginine, tyrosine, isoleucine, valine, proline, leucine Acid, Lysine Acetate, Methionine, Threonine, Alanine, Glutamic Acid, Aspartic Acid, Serine, N-Acetyl-L-Tryptophan, Glycine, Phenylalanine, Histamine After the acid and cysteine ​​hydrochloride are fully dissolved, dissolve sodium metabisulfite with a small amount of water, pour it into a ...

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Abstract

The invention discloses a compound amino acid injection (18AA-IV) composition, each 1000ml of which comprises 4.0-4.5g of leucine, 1.5-2.0g of isoleucine, 4.0-4.5g of lysine acetate, 1.0-1.5g of methionine, 1.8-2.2g of histidine, 0.10-0.15g of tyrosine, 1.8-2.3g of alanine, 3-4g of glycine, 1.0-1.5g of aspartate, 2.0-2.5g of glutamic acid, 1.0-1.5g of proline, 3.0-3.5g of phenylalanine, 2.0-2.5g of threonine, 0.3-0.8g of N-acetyl L-acetyl, 1-2g of valine, 0.5-1g of serine, 2-3g of arginine, 0.2-0.7g of cysteine hydrochloride and 70-80g of glucose. The compound amino acid injection (18AA-IV) composition is characterized by containing 0.5-5g of citric acid per 1000ml.

Description

Technical field: [0001] The invention relates to an amino acid-containing injection and a manufacturing method thereof. Background technique: [0002] Amino acids are the basic units that make up proteins. Compound amino acid injection, as a nutritional supplement for intravenous injection, is widely used in nutritional support therapy, such as the existing 18 kinds of amino acid compound injection with the general name of compound amino acid injection (18AA-IV), its formula is to contain bright Amino acid 4.17g, isoleucine 1.87g, lysine acetate 4.13g, methionine 1.17g, histidine 2.00g, tyrosine 0.116g, alanine 2.07g, glycine 3.57g, asparagine Amino acid 1.27g, glutamic acid 2.17g, proline 1.10g, phenylalanine 3.11g, threonine 2.17g, N-acetyl L-tryptophan 0.52g, valine 1.50g, serine 0.73g , arginine 2.63g, cysteine ​​hydrochloride 0.48g, glucose 75g, sodium metabisulfite 1.0g, due to the higher glucose content in the injection, the injection containing glucose will be Dec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4172A61K31/405A61K31/401A61K31/198A61K31/195A61K47/12A61P3/02
Inventor 何光杰袁英凌可均常翔
Owner TIANJIN JINYAO GRP
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