Compound amino acid injection and preparation method thereof

A compound amino acid and injection technology, applied in the field of injection, can solve the problems of reduced supplement effect, time-consuming, low utilization, etc., and achieve the effect of reasonable formula, good absorption by human body and long-lasting effect

Inactive Publication Date: 2017-03-15
安徽富邦药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common amino acid supplements are divided into oral and injection. Oral amino acid supplements are easy to carry and can be taken at any time. However, oral amino acid supplements are absorbed and utilized through the digestive system. Transaminases in the liver will remove the amino groups from amino acids. Amino acids are converted into glucose, the availability is low, and

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  • Compound amino acid injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] This embodiment provides a compound amino acid injection, which contains the following solutes per 1000 mL of injection: 9.1 g of isoleucine, 12.9 g of leucine, 10 g of lysine acetate, 4.4 g of methionine, and phenylalanine 7g, threonine 7.5g, tryptophan 1.3g, valine 14g, alanine 7.1g, arginine 9g, aspartic acid 1g, glutamic acid 0.5g, histidine 5g, proline 5g, 1.7g of serine, 0.4g of tyrosine, 7g of glycine, 0.35g of cysteine ​​and 0.3g of sodium bisulfite, appropriate amount of water for injection;

[0017] The preparation method of above-mentioned compound amino acid injection, it comprises the following steps:

[0018] (a) Bottle washing: respectively use alkaline water (the mass concentration of NaOH is 1-2%), drinking water, purified water and water for injection (the above-mentioned waters are all at 45-55°C, and the pressure is not lower than 0.15MPa);

[0019] (b) Dosing: Dissolve the antioxidant in water for injection to form an antioxidant solution, heat it ...

Embodiment 2

[0022] This embodiment provides a compound amino acid injection, the formula of which is basically the same as that in Example 1. The difference is that the step (b) is: first dissolve the antioxidant in water for injection to form an antioxidant solution, and then dissolve it in Heating to 70°C, blowing nitrogen into it so that the dissolved oxygen does not exceed 0.5ppm, under the conditions of constant nitrogen filling and stirring, add arginine and stir to dissolve, then add serine, glutamic acid, glycine, valine in sequence Acid, phenylalanine, alanine, aspartic acid, proline, tyrosine, isoleucine, leucine, histidine, threonine and methionine were stirred and dissolved; cooling To 45°C, add cysteine, lysine acetate and tryptophan in turn under stirring conditions, and replenish water for injection to the full amount; add 0.02% of the mass fraction of activated carbon for needles to control its pH to about 6.8 , add water for injection to the full amount; filter through a ...

Embodiment 3

[0024] This embodiment provides a compound amino acid injection, the formula of which is basically the same as that in Example 1. The difference is that the step (b) is: first dissolve the antioxidant in water for injection to form an antioxidant solution, and then dissolve it in Heat to 60°C, feed nitrogen into it so that the dissolved oxygen does not exceed 0.5ppm, add arginine and stir to dissolve under the condition of constant nitrogen filling and stirring, then add serine, glutamic acid, glycine, valine in sequence Acid, phenylalanine, alanine, aspartic acid, proline, tyrosine, isoleucine, leucine, histidine, threonine and methionine were stirred and dissolved; cooling to 30°C, add cysteine, lysine acetate and tryptophan in turn under stirring conditions, and replenish water for injection to the full amount; add 0.1% of the mass fraction of activated carbon for needles to control its pH to about 7.8 , add water for injection to the full amount; filter through a melt-blow...

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Abstract

The invention relates to a compound amino acid injection and a preparation method thereof. Every 1,000 mL of the injection contains 9-12 g of isoleucine, 12.5-15 g of leucine, 9-10.5 g of lysine acetate, 4-4.5 g of methionine, 6.5-7 g of phenylalanine, 7-7.5 g of threonine, 1-1.3 g of tryptophan, 14-16 g of valine, 6.5-7.5 g of alanine, 9-10 g of arginine, 0.8-1 g of aspartic acid, 0.3-0.8 g of glutamic acid, 4.5-5 g of histidine, 4.5-5 g of praline, 1.5-1.8 g of serine, 0.4-0.6 g of tyrosine, 6.5-7 g of glycine, 0.3-0.5 g of cysteine and 0.01-0.3 g of an antioxidant. Accordingly, the amino acid supplementing and absorbing effects are improved, a user can keep vigorous, the time needed when a large amount of injection is injected is shortened, drug stimulation generated when a large amount of injection is injected is reduced, the defects of an existing amino acid injection are greatly overcome, and the advantages of being reasonable in formula, durable in effect and good in human body absorption and health care effect are achieved.

Description

technical field [0001] The invention belongs to the field of injections, and relates to an amino acid injection, in particular to a compound amino acid injection and a preparation method thereof. Background technique [0002] The basic unit of protein structure is the amino acid. The human body needs to take in a certain amount of protein every day to meet the needs of life activities. When it is unable to take in enough amount from the gastrointestinal tract for some reason, it must be supplemented by intravenous amino acid solution. Compound amino acid injection (18AA) is A very important amino acid supplement and therapeutic agent, which plays an important role in clinical practice. Leucine, isoleucine, and valine, the mixture of three amino acids in essential amino acids, are called branched-chain amino acids. It is a very important and effective nutritional supplement, which can help organisms naturally , Strengthen muscles or gain more energy without side effects, es...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61K9/08A61P3/02A61K31/405A61K31/401A61K31/198A61K31/195
CPCA61K31/198A61K9/0019A61K9/08A61K31/195A61K31/401A61K31/405A61K31/4172A61K47/02A61K47/22A61K2300/00
Inventor 李帼蓉盛程洁赵自育李家仙陈春红黄娟张玉萍
Owner 安徽富邦药业有限公司
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