Methods to inhibit infection during wound healing with topical compositions including amino acids

a technology of topical compositions and amino acids, which is applied in the direction of biocide, drug compositions, peptide/protein ingredients, etc., can solve the problems of slowed wound healing and major impediment to wound healing, and achieve the effect of inhibiting infection

Active Publication Date: 2016-04-21
PLUMB JOHN H
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011]The present disclosure may further provide a method that inhibits infection during wound healing by topical application of a single composition that contacts a wound for a period of time to initiate wound healing, where the single composition may comprise one of the following amino acids: histidine; isoleucine; leucine; lysine; methionine; phenylalanine; threonine; valine; alanine; arginine; glutamine; glycine; proline; and serine. Each of the one of the following amino acids may provide an osmolarity of at least 120 mmol / liter, when mixed in one of: water, and an aqueous exudate in and around a wound site. The osmolarity of at least 120 mmol / liter is determined by a maximum aqueous solubility of each of the one of the following amino acids.
[0014]The present disclosure may yet further provide a method that inhibits infection during wound healing by topical application of a single composition that contacts a wound for a period of time to initiate wound healing, where the single composition may comprise: at least two of the following amino acids: histidine; isoleucine; leucine; lysine; methionine; phenylalanine; threonine; tryptophan; valine; alanine; aspartic acid; arginine; aspartic acid; glutamine; glycine; proline; serine; and tyrosine, while excepting the pairs of aspartic acid-tryptophan, aspartic acid-tyrosine, and tryptophan-tyrosine, and the triplet of aspartic acid-tryptophan-tyrosine. At least two of the amino acids, excepting the pairs of aspartic acid-tryptophan, aspartic acid-tyrosine, and tryptophan-tyrosine, and the triplet of aspartic acid-tryptophan-tyrosine, may provide an osmolarity of at least 120 mmol / liter, when mixed in one of: water, and an aqueous exudate in and around a wound site. The osmolarity of at least 120 mmol / liter may be determined by a maximum aqueous solubility of each constituent of at least two of the amino acids.

Problems solved by technology

Bacterial infection of a wound is a major impediment to wound healing.
Wound healing is slowed by poor perfusion of nutrients to the wound site, where they are needed for wound repair.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0087]A single composition, to be topically applied at a wound site to inhibit bacterial infection and provide one or more nutrients, that may comprise a mixture of amino acids, including each of the indispensable amino acids and each of the following conditionally indispensable and dispensable amino acids. Table 1 specifies the following proportional number of moles and equivalent weights, plus or minus 5 percent, for a mixture of amino acids having a total number of moles equal to 650 mmol in the single composition.

TABLE 1histidine•HCl•H2O9.743 mmol and 2.042 gisoleucine54.594 mmol and 7.157 gleucine109.264 mmol and 14.332 glysine acetate21.402 mmol and 4.414 gmethionine21.229 mmol and 3.168 gphenylalanine27.034 mmol and 4.466 gthreonine29.062 mmol and 3.462 gtryptophan5.424 mmol and 1.108 gvaline61.095 mmol and 7.157 galanine50.321 mmol and 4.483 garginine acetate28.227 mmol and 6.612 gaspartic acid54.582 mmol and 6.067 gglutamine76.100 mmol and 11.121 gglycine46.232 mmol and 3.4...

example 2

[0088]A single composition, to be topically applied at a wound site to inhibit bacterial infection and provide one or more nutrients, that may comprise a mixture of: amino acids, including each of the indispensable amino acids and each of the following conditionally indispensable and dispensable amino acids; and a carbohydrate. Table 2 specifies the following proportional number of moles and equivalent weights, plus or minus 5 percent, for a mixture of amino acids having a total number of moles equal to 650 mmol and a carbohydrate in the single composition.

TABLE 2histidine•HCl•H2O9.743 mmol and 2.042 gisoleucine54.594 mmol and 7.157 gleucine109.264 mmol and 14.332 glysine acetate21.402 mmol and 4.414 gmethionine21.229 mmol and 3.168 gphenylalanine27.034 mmol and 4.466 gthreonine29.062 mmol and 3.462 gtryptophan5.424 mmol and 1.108 gvaline61.095 mmol and 7.157 galanine50.321 mmol and 4.483 garginine acetate28.227 mmol and 6.612 gaspartic acid54.582 mmol and 6.067 gglutamine76.100 mmo...

example 3

[0089]A single composition, to be topically applied at a wound site to inhibit bacterial infection and provide one or more nutrients, that may comprise a mixture of: amino acids, including each of the indispensable amino acids and each of the following conditionally indispensable and dispensable amino acids; a carbohydrate; another mixture of fatty acids, vitamins, and mineral nutrients; and yet another mixture of amino acid derivatives and preservatives. Table 3 specifies the following proportional number of moles and equivalent weights, plus or minus 5 percent, for a mixture of amino acids having a total number of moles equal to 650 mmol in the single composition.

TABLE 3histidine•HCl•H2O9.743 mmol and 2.042 gisoleucine54.594 mmol and 7.157 gleucine109.264 mmol and 14.332 glysine acetate21.402 mmol and 4.414 gmethionine21.229 mmol and 3.168 gphenylalanine27.034 mmol and 4.466 gthreonine29.062 mmol and 3.462 gtryptophan5.424 mmol and 1.108 gvaline61.095 mmol and 7.157 galanine50.321...

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Abstract

A method that inhibits infection during wound healing by topical application of a single composition, which contacts a wound for a period of time to initiate wound healing. The single composition may include a mixture of all or some of the amino acids including: histidine monohydrochloride monohydrate; isoleucine; leucine; lysine acetate; methionine; phenylalanine; threonine; tryptophan; valine; alanine; arginine acetate; aspartic acid; glutamine; glycine; proline; serine; and tyrosine, which may provide aqueous mixtures of a range of osmolarities or a powdered mixture of amino acids. The single composition may also include any of a carbohydrate, a mixture of fatty acids, vitamins, and mineral nutrients, and another mixture of amino acid derivatives and preservatives. The number of moles of the carbohydrate is less than and proportional to a sum of the number of moles of any mixture of amino acids in the single composition.

Description

BACKGROUND[0001]1. Field of the Invention[0002]The present disclosure relates to methods that inhibit infection during wound healing by topical application of a single composition that contacts a wound for a period of time sufficient to initiate wound healing. Specifically, the present disclosure relates to the topical application of a single composition comprising an aqueous mixture of one or more amino acids that is applied to a wound site. The present disclosure also specifically relates to a topical application of a single composition comprising one or more powdered amino acids that forms a mixture with the exudate of a wound.[0003]2. Description of Related Art[0004]Wound healing is a complex metabolic process whereby the skin, or another organ-tissue, repairs itself after injury resulting from any of burns, mechanical trauma, surgery, pressure ulcers, and diabetic lesions. Classically, wound healing has been divided into four overlapping phases: hemostasis, inflammation, cellul...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/4172A61K31/405A61K31/401A61K31/716A61K33/30A61K31/07A61K31/593A61K31/355A61K31/195A61K31/198A61K31/202
CPCA61K31/4172A61K31/198A61K31/405A61K31/401A61K31/716A61K33/30A61K31/07A61K31/593A61K31/355A61K31/195A61K31/202A61P17/02A61P31/02A61K2300/00
Inventor PLUMB, JOHN H.
Owner PLUMB JOHN H
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