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Compound alpha-keto acid tablets and preparation method and detection method thereof

A detection method, the technology of ketoacid tablets, applied in the field of medicine, can solve the problems of poor granulation, inconvenient industrial production, granule compressibility, fluid granule hardness and dissolution rate are not ideal, and achieve high cost results

Active Publication Date: 2013-03-13
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the adjuvant of above-mentioned compound α-ketoacid tablet is poor in granulation, and the hardness and dissolution rate of granule compressibility, fluidity and granule are not ideal; Therefore, the quality of the prepared preparations cannot be guaranteed, and the requirements of industrial production cannot be facilitated.

Method used

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  • Compound alpha-keto acid tablets and preparation method and detection method thereof
  • Compound alpha-keto acid tablets and preparation method and detection method thereof
  • Compound alpha-keto acid tablets and preparation method and detection method thereof

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Embodiment Construction

[0386] Ketoisoleucine Calcium 67mg, Ketoleucine Calcium 101mg, Ketophenylalanine Calcium 68mg, Ketovaline Calcium 86mg, Racemic Hydroxymethionine Calcium 59mg, Acetate Lysine 105mg, Threonine 53mg, Tryptophan 23mg, histidine 38mg, tyrosine 30mg, respectively pulverize the above-mentioned main ingredients through a 100-mesh sieve; take 95mg of starch, 20mg of talcum powder, and 20mg of magnesium stearate and pass through a 80-mesh sieve respectively; Mix evenly with starch, and use 6% PVP k30 isopropanol solution to make soft material, granulate with 20 mesh sieve, and dry at 40°C; Mix evenly; test the intermediate, determine the tablet weight, and compress the tablet; coat the tablet to obtain the compound α-keto acid tablet.

[0387] The detection method of this compound α-keto acid tablet includes:

[0388] (1) traits

[0389] Compound a-ketoacid tablets are yellow film-coated tablets, which are white or off-white after removing the film coat;

[0390] (2) Identification ...

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Abstract

The invention discloses compound alpha-keto acid tablets and a preparation method and a detection method thereof. The preparation method comprises the following steps of: taking calcium 3-methyl-2-oxovalerate, ketoleucine calcium, alpha-ketophenylalanine calcium, keto-valine-calcium, D,L-alpha-hydroxymethionine calcium, lysine acetate, threonine, tryptophan, histidine and tyrosine, crushing the main medicaments respectively and sieving with a sieve of 100 meshes; sieving starch, talc powder and magnesium stearate and sieving with a sieve of 80 meshes respectively; mixing the main medicaments and the starch uniformly, preparing a soft material from 6 percent polyvinyl pyrrolidone (PVP) k30 isopropanol solution, granulating with a sieve of 20 meshes, and drying at the temperature of 40 DEG C; reshaping, adding magnesium stearate, the talc powder and crosslink povidone, and mixing uniformly; detecting an intermediate, and tabletting; and coating, and thus obtaining the compound alpha-keto acid tablets. The tablets with excellent granule pressing property, flowability, hardness and dissolution degree can be prepared by using the method, and the detection method can further ensure the quality of the prepared compound alpha-keto acid tablets.

Description

technical field [0001] The invention relates to a compound α-keto acid tablet, a preparation method and a detection method thereof, and belongs to the technical field of medicine. Background technique [0002] In developed countries, the prevalence of chronic kidney disease (CKD) in the general population is as high as 6.5% to 10%, and the number of kidney disease patients in the United States has exceeded 20 million. According to the information provided by the Tianjin Branch of the Chinese Society of Nephrology, the latest survey results show that the prevalence of chronic kidney disease among people over 40 years old in my country is as high as 8% to 9%, and the incidence is still on the rise. [0003] Nutritional therapy has always been an effective measure to delay the progression of CKD and alleviate the symptoms of uremia. Restricting protein intake while supplementing essential amino acids can help patients achieve nitrogen balance. According to Brenner's "Ultrafilt...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61K31/405A61K31/195A61K31/19A61K9/20A61P13/12A61P3/02G01N30/02G01N21/79G01N21/31
Inventor 张观福
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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