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Sedation pharmaceutical use of paecilomyces Gunnii mycelium and its extract

A technology of Paecilomyces gunini and Paecilomyces niserii, which is applied in the field of sedative drug application of Paecilomyces gunini mycelium and its extract

Inactive Publication Date: 2009-04-08
ZHEJIANG BIOASIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, there is no relevant report and application of Paecilomyces gourni for medical use in sedation

Method used

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  • Sedation pharmaceutical use of paecilomyces Gunnii mycelium and its extract
  • Sedation pharmaceutical use of paecilomyces Gunnii mycelium and its extract
  • Sedation pharmaceutical use of paecilomyces Gunnii mycelium and its extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The mice used were Kunming mice, half male and half female, weighing 18-22 g, purchased from the Experimental Animal Center of Anhui Medical University (Wanyishidongzhun No. 01).

[0032] The Paecilomyces gourni mycelium powder used was self-made, and distilled water was used to make the required concentration during the experiment; Anshen Bunao liquid was produced by Jilin Aodong Yanbian Pharmaceutical Co., Ltd.

[0033] The preparation method of Paecilomyces gunini mycelium is as follows, and the flowchart is shown in the attached figure 1 .

[0034] The isolation method of the strain is as follows: on the ultra-clean workbench, under aseptic conditions, rinse the harvested fresh Cordyceps sinensis with obviously mature ascus with sterile water, and place them in a sterilized petri dish with a diameter of 15 cm. , the inner sclerotia of Cordyceps is wrapped with moistened absorbent cotton to keep moisture. A sterilized glass slide is placed under the fertile part of...

Embodiment 2

[0066] Paecilomyces gourni mycelium was prepared according to the method of Example 1. The dry mycelium of Paecilomyces gunini obtained is carried out to the following extraction process to obtain the extract (see figure 1 ).

[0067] The obtained extract was tested according to the conditions in Example 1. The experimental results of the spontaneous activity recording method are shown in Table 3;

[0068] Table 3 Effect of dry mycelium extract of Paecilomyces gourini on spontaneous activity in mice

[0069] (Spontaneous activity meter recording method, χ±s, n=8)

[0070]

[0071] Compared with the control group, ＊ P＊＊ P<0.01

[0072] Table 4 The effect of Paecilomyces gunini dry mycelium extract on the walking time of mice and the number of lifts of forelimbs upwards (χ±s, n=8)

[0073]

[0074] Compared with the control group, ＊ P＊＊ P<0.01

[0075] It can be seen from the above experiments that the Paecilomyces gourni mycelia and its extracts have a certain seda...

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Abstract

The invention discloses application of a mycelium from paecilomyces gunnii and a sedative which is an extract of the mycelium from the paecilomyces gunnii. In particular, the mycelium from the paecilomyces gunnii and the extract of the mycelium from the paecilomyces gunnii have sedative effect, and can be used as sedatives. The invention belongs to the field of medicine application.

Description

technical field [0001] The present invention relates to the new medical application of Paecilomyces gunini mycelium and its extract, in particular to the sedative medicine application of the Paecilomyces gunini mycelium and its extract. Background technique [0002] With the deepening of research on Cordyceps, Guni Cordyceps has gradually become another important resource of Cordyceps after Cordyceps sinensis. Since Cordyceps Cordyceps was first reported in my country in 1983, Liang Zongqi and others have done a lot of research work on its strain isolation, anamorphic determination, nutritional components, pharmacological experiments and liquid fermentation, etc., showing that Cordyceps Cordyceps can improve the immune system It plays a very important role in promoting sleep, enhancing memory, and analgesia. With the continuous improvement of experimental technology, Cordyceps guni still has great application research potential. [0003] In 1985, Liang Zongqi first reported...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P25/20C12N1/14C08B37/00
Inventor 樊美珍李春如黄勃
Owner ZHEJIANG BIOASIA PHARMA CO LTD
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