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Anti-infective solution comprising a compound of pyrido(3,2,1-ij)-benzoxadiazine type

A technology of benzoxadiazines and compounds, which is applied in the field of concentrated solutions, can solve the problems of inapplicable and incapable of all molecular types, and play a sufficient role.

Active Publication Date: 2009-04-08
VETOQUINOL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, this type of formulation, previously designed for use with tetracyclines, may prove to be unsuitable or insufficiently effective for all molecule types, especially when certain quinolones are involved

Method used

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  • Anti-infective solution comprising a compound of pyrido(3,2,1-ij)-benzoxadiazine type
  • Anti-infective solution comprising a compound of pyrido(3,2,1-ij)-benzoxadiazine type
  • Anti-infective solution comprising a compound of pyrido(3,2,1-ij)-benzoxadiazine type

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] The solutions described in Table 1 below were prepared:

[0078] 1st copy

comparative example

Marbofloxacin (unit g)

15.00

10.0 0

Gluconolactone (unit g)

8.11

8.00

demineralized water qsp

100ml

100ml

[0079] Pigs with a weight of 70-80kg received intramuscular injection, and the injection solution was a single comparative solution in the right column or the first solution in the left column, and the dose was 8ml / kg. One week after dosing, local tolerance (damage) was checked.

[0080] Injection of the first solution presents a lesion volume of approximately 9 cm 3 , while the injection solution of the comparative example exhibits up to 32cm 3 damage volume.

[0081] The results indicated that the concentrated solution of marbofloxacin exhibited better local tolerance compared to the control solution.

Embodiment 2

[0083] The following solutions were prepared:

[0084] 1st copy

2nd copy

3rd copy

4th copy

Marbofloxacin

20.00g

20.00g

20.00g

20.00g

Gluconolactone

19.00g

19.00g

17.00g

17.00g

Benzyl alcohol

-

2.00g

-

2.00g

demineralized water

qsp100ml

qsp100ml

qsp100ml

qsp100ml

stability at low temperature

24 hours

>7 days *

24 hours

>7 days *

[0085] * After 7 days, no precipitation was found.

[0086] "Stability at low temperature" refers to the time for each solution to stand at +4 to +8°C until a precipitate forms.

[0087] The above data clearly show the improved stability of the solutions of the invention.

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PUM

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Abstract

The present invention relates to an anti-infective solution comprising at least one compound of pyrido(3r ,2, 1-ij)benzoxadiazine type corresponding to the following formula (I): or at least one of its pharmaceutically acceptable salts, and at least one solubilizing agent, in a pharmaceutically acceptable carrier.

Description

technical field [0001] The technical field of the invention relates to an anti-infective solution for the treatment of animals. [0002] The invention more particularly relates to an anti-infective solution, in particular a concentrated solution, containing at least one pyrido(3,2,1-ij)benzoxadiazine compound. Background technique [0003] It is very common to administer anti-infective products for therapeutic, prophylactic or quasi-prophylactic purposes to livestock such as cattle, pigs, goats, sheep, poultry and / or horses, as well as pets, especially by injection. [0004] The amount of product to be administered parenterally and the number of injection sites are important considerations when selecting a product formulation. The purpose of making concentrated formulations is to reduce the amount and / or frequency of administration, especially in livestock, to reduce the muscle areas that cannot be processed at slaughter. Another factor to consider when preparing concentra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/26A61K47/12A61K47/02A61P31/00
CPCA61K31/5395A61K9/0019A61P31/00
Inventor M·莫罗
Owner VETOQUINOL SA
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