Preparation method of external natural diatomite emergency life-saving hemostat

A technology of natural diatomite and hemostatic agent, applied in the fields of medical science, bandages, absorbent pads, etc., to achieve the effect of small bulk density, good hemostatic effect and less heat release

Inactive Publication Date: 2009-04-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no domestic and foreign patent reports on the application of natural diatomite in blood coagulation materials, wound treatment and trauma repair, and the combination of natural diatom earth with medical bandages and medical adhesives for trauma repair

Method used

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  • Preparation method of external natural diatomite emergency life-saving hemostat
  • Preparation method of external natural diatomite emergency life-saving hemostat
  • Preparation method of external natural diatomite emergency life-saving hemostat

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Experimental program
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Effect test

Embodiment 1

[0024] The natural diatomite in Shengxian County, Zhejiang Province is selected as the raw material. The main components are: silicon oxide, aluminum oxide, iron oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide. The content of silicon oxide exceeds 60%, and its XRD pattern is shown in attached figure 1 , see the original map of the ore figure 2 . .

[0025] Put a certain amount of natural diatomite from Sheng County, Zhejiang Province into a traditional Chinese medicine pulverizer, the pulverization time is about 5 minutes, and the particle size after pulverization is between 1 micron and 1 mm. Dry in an oven at 100°C for 1 hour to obtain a natural diatomaceous earth emergency life-saving hemostatic agent. Its hemostatic effect is similar to that of Quikclot. The in vitro coagulation experiment is carried out on a silent mixer. Take a certain amount of blood stabilized by adding sodium citrate, add an appropriate amount of calcium chloride to determi...

Embodiment 2

[0027] The natural diatomite was treated in a muffle furnace at 300°C, 500°C, and 700°C for 4 hours respectively, and then dried in an oven at 100°C for 1 hour to obtain a heat-treated natural diatomite emergency life-saving hemostatic agent. Its hemostatic effect is similar to that of Quikclot, see attached image 3 .

Embodiment 3

[0029] Take 1g of natural diatomaceous earth hemostatic agent and 1g of Quikclot respectively in a test tube, then add 1ml of water, measure the temperature change with an infrared sensor, and reflect the thermal effect through the temperature change. The thermal effect is shown in the attached Figure 4 .

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Abstract

The invention discloses a preparing method for a topical natural diatomite emergency hemostat. The natural diatomite is used as a material; the content of monox in the material is more than 60 percent; the layer distance is between 1.0 and 2.0nm; and the specific surface is 30 to 1000m<2> / g. The preparation method comprises the following steps: the natural diatomite is cracked into grains of different sizes by a Chinese medicine cracker; the diameters of the grains are between 1micron to 1mm; the cracked natural diatomite is heated and treated for 1 to 24 hours directly at the temperature between 60 and 900 DEG C to obtain the topical natural diatomite emergency hemostat. The preparation method is simple; the material is abundant, cheap and easy to be obtained; and the topical natural diatomite emergency hemostat is convenient for being applied and has a good stanching effect.

Description

technical field [0001] The invention relates to a natural diatomite emergency life-saving hemostatic agent for external use and a preparation method thereof, in particular to a natural diatomite hemostatic agent for treating fatal large-vessel hemorrhage uncontrollable by conventional hemostatic measures and a preparation process thereof. Background technique [0002] Emergency life-saving hemostatic agent is an emerging research field in the world. Emergency life-saving hemostats are primarily developed for emergencies where bleeding does not stop in trauma. An emergency like aortic bleeding can be contained within a short period of time (3 minutes), gaining valuable time for further medical treatment. [0003] According to the statistics of the Ministry of Health in 2007, there are about 200 million people with various injuries every year, and about 700,000 to 750,000 deaths due to injuries such as wars, traffic accidents, and major natural disasters. Excessive blood loss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18
Inventor 范杰李云龙肖丽萍胡笑月马桂岑
Owner ZHEJIANG UNIV
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