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Novel vaccine adjuvant

An adjuvant and vaccine technology, applied in the direction of antiviral agents, viral antigen components, oil/fat/wax non-effective components, etc., to achieve the effects of long immunization cycle, unique stability, and no vaccine side reactions

Active Publication Date: 2013-01-02
BEIJING HUAXIA XINGYANG BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surface-modified nanoparticles can fully expose the surface of the protein antigen, and at the same time make the antigen structure more stable, causing a strong and specific immune response after injection, while ordinary adjuvants do not have this function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]1. Preparation of the aqueous phase of the adjuvant: add 0.4g of baicalin and 2ml of Tween-80 to every 100ml of water, and fully dissolve;

[0038] 2. Preparation of adjuvant oil phase: add 2g of aluminum stearate and 2ml of Span-80 to every 100ml of white oil for injection;

[0039] 3. Emulsify and mix the water phase and oil phase according to the ratio of 1:1;

[0040] 4. The emulsion is nano-treated with a high-pressure homogenizer;

[0041] 5. Use a 0.22 μm microporous membrane to filter and sterilize to obtain Adjuvant 1.

Embodiment 2

[0043] 1. Preparation of the aqueous phase of the adjuvant: add 10 g of chitosan and 10 ml of Tween-80 to 100 ml of water, fully dissolve and mix;

[0044] 2. Preparation of adjuvant oil phase: add 1g of aluminum stearate and 10ml of Siban-80 to 100ml of white oil for injection, and mix thoroughly;

[0045] 3. Emulsify and mix the water phase and the oil phase at a ratio of 5:1.

[0046] 4. The emulsion is nano-treated with a high-pressure homogenizer;

[0047] 5. Use a 0.22 μm microporous membrane to filter and sterilize to obtain adjuvant 2.

Embodiment 3

[0049] 1. Preparation of the aqueous phase of the adjuvant: add 2g of astragalus polysaccharide and 3ml of Tween-80 to 100ml of water, fully dissolve and mix;

[0050] 2. Preparation of adjuvant oil phase: add 6g of lecithin and 7ml of Span-80 to 100ml of white oil for injection, fully dissolve;

[0051] 3. Emulsify and mix the water phase and oil phase according to the ratio of 2:1;

[0052] 4. The emulsion is nano-treated with a high-pressure homogenizer;

[0053] 5. Use a 0.22 μm microporous membrane to filter and sterilize to obtain Adjuvant 3.

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Abstract

The invention discloses a nanometer particle adjuvant, a preparation method thereof, and the application thereof in the preparation of inactivated vaccines. According to the invention, a novel nanometer particle adjuvant is obtained through preparation by the emulsion preparation and the nanometer treatment following the dissolving of different immunopotentiator and surfactant in water and oil respectively. The adjuvant provided by the invention not only can remarkably improve the humoral immune response and the cellular immune response of various bacterial and viral inactivated vaccines, butalso has unique advantages in the preparation process, the stability, the immunity duration and the side reaction of vaccines.

Description

technical field [0001] The invention relates to a nanoparticle adjuvant, its preparation method and its application in the preparation of inactivated vaccines. technical background [0002] Adjuvant is a kind of substance that can non-specifically change or enhance the body's specific immune response to antigens before or at the same time as antigens. Adjuvants basically behave in the following possible ways: a. Increase the physiological or immune half-life of vaccine antigens. b. Increase the surface area of ​​the antigen to improve the carrying and presentation of the antigen. c. Induce the production of immunomodulatory cytokines. d. Induction of CD8+ cytotoxic T cell responses. [0003] Adjuvants are not only important components in the production of inactivated vaccines, but also play a role in improving the immune effect of attenuated vaccines. Especially in inducing a more effective antiviral immune response, the participation of T cell immunity is essential. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61K39/00A61K39/135A61K39/145A61K39/17A61K39/205A61K39/265A61K9/14A61K47/44A61P31/12
Inventor 江厚生王秀敏赵卓
Owner BEIJING HUAXIA XINGYANG BIOLOGICAL SCI & TECH
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