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Chinese patent medicine drop-pills for treating kidney deficiency, preparation method and use thereof

A technology of Chinese patent medicines and dripping pills, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of long dissolution time of shrinking pills, slow oral absorption, dust pollution, etc. question

Inactive Publication Date: 2009-06-17
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Shuoquan Pills are known to be used to treat enuresis in children, frequent urination in the elderly and other diseases, and have been proved to have significant curative effect after years of clinical practice, but due to the limitation of dosage form and dosage, it is far from meeting the needs of the majority of patients
[0005] Its limitations are mainly as follows: firstly, the dissolution time of Shuoquan Pills is longer (30 minutes), resulting in slower oral absorption, which reduces the bioavailability and is not conducive to the efficacy of the drug; Amount of 3 to 6 grams (60 to 120 pills) will cause inconvenience to patients, especially the elderly; moreover, the finished product needs to be improved in terms of solubility, dissolution rate, bioavailability and stability; and the production process There is dust pollution in the environment, which is not conducive to labor protection

Method used

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  • Chinese patent medicine drop-pills for treating kidney deficiency, preparation method and use thereof
  • Chinese patent medicine drop-pills for treating kidney deficiency, preparation method and use thereof
  • Chinese patent medicine drop-pills for treating kidney deficiency, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1, the preparation of shrinking spring dripping pills

[0068] 1. Prescription: Yizhi Ren 500g, Chinese Yam 500g, Wuyao 500g

[0069] 2. Preparation method:

[0070] 1) Medicinal material treatment: Add 500g of Yizhiren, 500g of Chinese yam and 500g of black yam, add 12000ml of water to extract the volatile oil for 5 hours, collect the volatile oil, extract the residue with 12000ml of water for 1 hour, concentrate the extract into an extract with a relative density of 1.10, add 950ml of 95% ethanol, stir evenly, let stand for 15 hours, filter with suction, evaporate the filtrate to dry ethanol, add water to 1500ml, mix well, then extract four times with ethyl acetate and n-butanol, 1500ml each time, and concentrate the extract to dryness Become an extract dry paste, the paste yield is 3.1%, and the extracted volatile oil is 3.3ml;

[0071] 2) Preparation of medicinal solution: take 69.8g of polyethylene glycol 4000 and put it in a liquid storage bottle, hea...

Embodiment 2

[0077] Embodiment 2, the preparation of shrinking spring dripping pills

[0078] 1. Prescription: Yizhi Ren 500g, Chinese Yam 500g, Wuyao 500g

[0079] 2. Preparation method:

[0080] 1) Medicinal material treatment: Add 500g of Yizhiren, 500g of Chinese yam and 500g of black yam, add 12000ml of water to extract the volatile oil for 5 hours, collect the volatile oil, extract the residue with 12000ml of water for 1 hour, concentrate the extract into an extract with a relative density of 1.10, add 950ml of 95% ethanol, stir evenly, let stand for 15 hours, filter with suction, evaporate the filtrate to dry ethanol, add water to 1500ml, mix well, then extract four times with ethyl acetate and n-butanol, 1500ml each time, and concentrate the extract to dryness Become an extract dry paste, the paste yield is 3.0%, and the extracted volatile oil is 3.3ml;

[0081] 2) Preparation of medicinal solution: take 90g of polyethylene glycol 6000 and put it in a storage bottle, heat it to 7...

Embodiment 3

[0087] Embodiment 3, the preparation of shrinking spring dripping pills

[0088] 1. Prescription: Yizhi Ren 500g, Chinese Yam 500g, Wuyao 500g

[0089] 2. Preparation method:

[0090] 1) Medicinal material treatment: add 500g of Yizhiren, 500g of Chinese yam and 500g of black yam into 9000ml of 95% ethanol and heat and reflux for extraction twice, each time for 1 hour, and the extract is filtered by suction; the residue is extracted twice with 12000ml of water, each time for 1 hour, The water extract is concentrated into an extract with a relative density of 1.12. Add 950ml of 95% ethanol for alcohol precipitation, stir evenly, let stand for 15 hours, filter with suction, evaporate the filtrate to dry ethanol, combine the alcohol extract and alcohol precipitation, and concentrate to a relative Density is 1.20 extract, add water to form 1500ml extract, mix well, then extract 4 times with ethyl acetate and n-butanol, 1500ml each time, extract is concentrated to dry to become ex...

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Abstract

The invention provides a Chinese patent medicine dripping pill for treating kidney deficiency. The dripping pill comprises: A, Chinese medicine materials as an active composition by weight portion: refined extracts of 1 to 3 portions of semen amomi amari, 1 to 3 portions of radices linderae and 1 to 3 portions of yam; and B, polyethylene glycol 6000 or polyethylene glycol 4000 as a substrate, wherein the weight portion ratio of the active composition A to the substrate B is 1:1.0-1:3. The invention also provides a method for preparing the dripping pill; and the invention simultaneously provides medical application of the dripping pill to treating kidney deficiency, frequent micturition, nocturnal enuresis, infantile enuresis and / or frequent micturition of elders. The Chinese patent medicine dripping pill has good application prospect in improving solubility, dissolving speed and bioavailability of the medicine and other aspects and is a leading-edge medicine preparation for treating the diseases of infantile enuresis and frequent micturition of elders and realizing modernized development of Chinese medicine.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations. Specifically, the present invention relates to a Chinese patent medicine drop pill for treating kidney deficiency. The present invention also relates to the drop pill and its preparation method. , The medicinal use of enuresis in children and / or frequent urination in the elderly. Background technique [0002] Frequent urination and enuresis are common urinary tract diseases, which are more common in women, children and the elderly. Its pathogenesis is due to deficiency of spleen and kidney qi, weakness of the lower yuan, and loss of bladder appointment. Enuresis as described in Chinese medicine can include two aspects of enuresis and incontinence clinically. Enuresis refers to a disease in which urination is self-inflicted during sleep, and it is mostly seen in children. Incontinence refers to frequent urination, dripping cannot be restrained, and it is more common in t...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K9/20A61K47/34A61P13/00
Inventor 张林林王顺仙郑国华
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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