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Application and preparing method of Chinese milkvetch seed extractive

A technology for extracts and uses, which is applied in the field of use and preparation of the Vetch chinensis extract, and achieves the effects of a reasonable and simple process, retaining effective components and reducing the dosage of administration.

Active Publication Date: 2011-09-21
浙江金石亚药医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application and preparing method of Chinese milkvetch seed extractive
  • Application and preparing method of Chinese milkvetch seed extractive
  • Application and preparing method of Chinese milkvetch seed extractive

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Astragalus vulgaris 2.5kg, fried coke, crushed, sieved through a 10-mesh sieve, 6 times 60% ethanol soaked for 2 hours, refluxed for 2 times, 2 hours each time, filtered with 2 layers of medical gauze, combined the filtrate, and reduced pressure (-0.08 -0.10MPa) After the ethanol is recovered, it is extracted three times with equal volumes of petroleum ether, ethyl acetate and n-butanol respectively, and the solvent is recovered under reduced pressure (-0.08-0.10MPa), dried under vacuum at 60°C, and placed in a dry box Activated carbon adsorbs residual n-butanol to obtain dry extract, which is crushed into fine powder for storage.

Embodiment 2

[0038] 28kg Astragalus vulgaris, fried coke, crushed, passed through a 10-mesh sieve, added 6 times of 60% ethanol, soaked for 2h, refluxed and extracted 2 times, 2h each time, filtered with 2 layers of medical gauze, combined the filtrate, and reduced pressure (-0.08- 0.10MPa) After the ethanol is recovered, it is adsorbed by D101 macroporous adsorption resin. After washing the column with 6 times the amount of water and 7 times the amount of 30% ethanol, it is eluted with 9 times the amount of 70% ethanol, and finally the column is washed with 95% ethanol. The solvent was recovered under reduced pressure (-0.08-0.10MPa) and dried in vacuum at 60°C to obtain a dry extract, which was crushed into fine powder for storage.

[0039] The related research results of the present invention are as follows:

[0040] 1. The effect of each extract in Example 1 on adriamycin nephropathy model rats

[0041] 1. Experimental animals: Healthy SD rats, male, weighing 350±20g, purchased from Zhejiang...

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Abstract

The invention discloses an application and preparing method of Chinese milkvetch seed extractive. Triterpenes, flavonoids and their glycosides as effective components are extracted out from Chinese milkvetch seed as raw material and used for reducing the urokinase protein and treating the nephrotic syndrome. Chinese milkvetch seed is extracted by the ethanol reflux extraction method, the solvent is recycled under decompression, the triterpenes, flavonoids and their glycosides are obtained after the macroporous polymeric adsorbent column chromatography or the n-butanol extraction separation. The Chinese milkvetch seed extractive has the functions of reducing the urokinase protein and treating the nephrotic syndrome, and can be taken for a long time without obvious noxious and side effect; the process is reasonable and simple, the effective components are remained, the dosage is reduced.

Description

Technical field [0001] The present invention relates to natural medicine technology, in particular to the use and preparation method of a milk vetch extract. Background technique [0002] The kidney is the vital organ of the five internal organs and is innate. Its function is to excrete the metabolites in the human body, reabsorb the useful components in the metabolites back into the body, and then discharge the waste produced—urine through the ureter and bladder. At the same time, the kidney is also a very important endocrine organ in the body, responsible for the production of erythropoietin that promotes hematopoiesis, active vitamin D3, and the decomposition of insulin in the body. Once kidney function is damaged, waste accumulates in the body, which will cause great harm to the body. [0003] At present, there are 90 million kidney patients in my country. Among them, uremia patients are increasing at a rate of 5%-10% every year. According to statistics, since 2006, chronic k...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P13/12A61K131/00
Inventor 曾永篪李军金圣煊孙静芸
Owner 浙江金石亚药医药科技有限公司
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